Výsledky vyhledávání - "Schmitt, Lukas"

Akademický článek

Discovery and characterization of novel Cre-type tyrosine site-specific recombinases for advanced genome engineering

Autor: Jelicic, Milica, Schmitt, Lukas Theo, Paszkowski-Rogacz, Maciej, Walder, Angelika, Schubert, Nadja, Hoersten, Jenna, Sürün, Duran, Buchholz, Frank

Tyrosine-type site-specific recombinases (Y-SSRs) are versatile tools for genome engineering due to their ability to mediate excision, integration, inversion and exchange of genomic DNA with single nucleotide precision. The ever-increasing need for s

Externí odkaz: https://tud.qucosa.de/id/qucosa%3A93599
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Akademický článek

Prediction of designer-recombinases for DNA editing with generative deep learning

Autor: Schmitt, Lukas Theo, Paszkowski-Rogacz, Maciej, Jug, Florian, Buchholz, Frank

Site-specific tyrosine-type recombinases are effective tools for genome engineering, with the first engineered variants having demonstrated therapeutic potential. So far, adaptation to new DNA target site selectivity of designerrecombinases has been

Externí odkaz: https://tud.qucosa.de/id/qucosa%3A91838
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Akademický článek

Correction of a Factor VIII genomic inversion with designer-recombinases

Autor: Lansing, Felix, Mukhametzyanova, Liliya, Rojo-Romanos, Teresa, Iwasawa, Kentaro, Kimura, Masaki, Paszkowski-Rogacz, Maciej, Karpinski, Janet, Grass, Tobias, Sonntag, Jan, Schneider, Paul Martin, Günes, Ceren, Hoersten, Jenna, Schmitt, Lukas Theo, Rodriguez-Muela, Natalia, Knöfler, Ralf, Takebe, Takanori, Buchholz, Frank

Despite advances in nuclease-based genome editing technologies, correcting human disease-causing genomic inversions remains a challenge. Here, we describe the potential use of a recombinase-based system to correct the 140 kb inversion of the F8 gene

Externí odkaz: https://tud.qucosa.de/id/qucosa%3A91150
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Report

Cutting circuits with multiple two-qubit unitaries

Autor: Schmitt, Lukas, Piveteau, Christophe, Sutter, David

Quasiprobabilistic cutting techniques allow us to partition large quantum circuits into smaller subcircuits by replacing non-local gates with probabilistic mixtures of local gates. The cost of this method is a sampling overhead that scales exponentia

Externí odkaz: http://arxiv.org/abs/2312.11638

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