Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectives

Autor: Schmidt BZ, Haaf JB, Leal T, Noel S

Publikováno v: Clinical Pharmacology: Advances and Applications, Vol Volume 8, Pp 127-140 (2016)

Béla Z Schmidt,1 Jérémy B Haaf,2 Teresinha Leal,2 Sabrina Noel,2 1Stem Cell Biology and Embryology, Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, 2Louvain Center for Toxicology and Applied Pharmacology, Univer

Externí odkaz: https://doaj.org/article/3216efb0df3941889a5dd4ef20f40d88

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The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods.

Autor: Krebs A; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany.; Konstanz Research School Chemical Biology, University of Konstanz, 78457, Konstanz, Germany., van Vugt-Lussenburg BMA; BioDetection Systems BV, Science Park 406, 1098 XH, Amsterdam, The Netherlands., Waldmann T; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany.; trenzyme GmbH, Byk-Gulden-Str. 2, 78467, Konstanz, Germany., Albrecht W; Leibniz-Institut für Arbeitsforschung an der TU Dortmund, Leibniz Research Center for Working Environment and Human Factors (IfADo), Ardeystraße 67, 44139, Dortmund, Germany., Boei J; Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands., Ter Braak B; Division of Drug Discovery and Safety, Leiden Academic Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands., Brajnik M; Edelweiss Connect GmbH, Technology Park Basel, Hochbergerstrasse 60C, 4057, Basel, Switzerland., Braunbeck T; Aquatic Ecology and Toxicology Group, Center for Organismal Studies, University of Heidelberg, Im Neuenheimer Feld 504, 69120, Heidelberg, Germany., Brecklinghaus T; Leibniz-Institut für Arbeitsforschung an der TU Dortmund, Leibniz Research Center for Working Environment and Human Factors (IfADo), Ardeystraße 67, 44139, Dortmund, Germany., Busquet F; CAAT Europe, University of Konstanz, Steinbeis SU-1866, 78457, Konstanz, Germany., Dinnyes A; BioTalentum Ltd., Aulich Lajos str. 26, Gödöllő, 2100, Hungary., Dokler J; Edelweiss Connect GmbH, Technology Park Basel, Hochbergerstrasse 60C, 4057, Basel, Switzerland., Dolde X; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany., Exner TE; Edelweiss Connect GmbH, Technology Park Basel, Hochbergerstrasse 60C, 4057, Basel, Switzerland., Fisher C; Simcyp Division, Certara UK Limited, Level 2-Acero, 1 Concourse Way, Sheffield, S1 2BJ, UK., Fluri D; InSphero AG, Wagistrasse 27, 8952, Schlieren, Switzerland., Forsby A; Unit of Toxicology Sciences, Swedish Toxicology Sciences Research Center (Swetox), Karolinska Institutet, Forskargatan 20, 151 36, Södertälje, Sweden.; Department of Biochemistry and Biophysics, Stockholm University, 10691, Stockholm, Sweden., Hengstler JG; Leibniz-Institut für Arbeitsforschung an der TU Dortmund, Leibniz Research Center for Working Environment and Human Factors (IfADo), Ardeystraße 67, 44139, Dortmund, Germany., Holzer AK; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany., Janstova Z; BioTalentum Ltd., Aulich Lajos str. 26, Gödöllő, 2100, Hungary., Jennings P; Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands., Kisitu J; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany.; Konstanz Research School Chemical Biology, University of Konstanz, 78457, Konstanz, Germany., Kobolak J; BioTalentum Ltd., Aulich Lajos str. 26, Gödöllő, 2100, Hungary., Kumar M; Department of Development and Regeneration, Stem Cell Biology and Embryology, Stem Cell Institute Leuven, KU Leuven, O&N IV Herestraat 49, 3000, Leuven, Belgium., Limonciel A; Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands., Lundqvist J; Unit of Toxicology Sciences, Swedish Toxicology Sciences Research Center (Swetox), Karolinska Institutet, Forskargatan 20, 151 36, Södertälje, Sweden.; Department of Biochemistry and Biophysics, Stockholm University, 10691, Stockholm, Sweden., Mihalik B; BioTalentum Ltd., Aulich Lajos str. 26, Gödöllő, 2100, Hungary., Moritz W; InSphero AG, Wagistrasse 27, 8952, Schlieren, Switzerland., Pallocca G; CAAT Europe, University of Konstanz, Steinbeis SU-1866, 78457, Konstanz, Germany., Ulloa APC; Unit of Toxicology Sciences, Swedish Toxicology Sciences Research Center (Swetox), Karolinska Institutet, Forskargatan 20, 151 36, Södertälje, Sweden., Pastor M; Department of Experimental and Health Sciences, Research Programme on Biomedical Informatics (GRIB), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Universitat Pompeu Fabra, 08003, Barcelona, Spain., Rovida C; CAAT Europe, University of Konstanz, Steinbeis SU-1866, 78457, Konstanz, Germany., Sarkans U; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK., Schimming JP; Leiden Academic Center for Drug Research, LACDR/Toxicology, Leiden University, PO Box 9500, 2300 RA, Leiden, The Netherlands., Schmidt BZ; Switch Laboratory, Department of Cellular and Molecular Medicine, VIB-KU Leuven Center for Brain and Disease Research, KU Leuven, Herestraat 49, 3000, Leuven, Belgium., Stöber R; Leibniz-Institut für Arbeitsforschung an der TU Dortmund, Leibniz Research Center for Working Environment and Human Factors (IfADo), Ardeystraße 67, 44139, Dortmund, Germany., Strassfeld T; InSphero AG, Wagistrasse 27, 8952, Schlieren, Switzerland., van de Water B; Leiden Academic Center for Drug Research, LACDR/Toxicology, Leiden University, PO Box 9500, 2300 RA, Leiden, The Netherlands., Wilmes A; Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands., van der Burg B; BioDetection Systems BV, Science Park 406, 1098 XH, Amsterdam, The Netherlands., Verfaillie CM; Department of Development and Regeneration, Stem Cell Biology and Embryology, Stem Cell Institute Leuven, KU Leuven, O&N IV Herestraat 49, 3000, Leuven, Belgium., von Hellfeld R; Aquatic Ecology and Toxicology Group, Center for Organismal Studies, University of Heidelberg, Im Neuenheimer Feld 504, 69120, Heidelberg, Germany., Vrieling H; Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands., Vrijenhoek NG; Leiden Academic Center for Drug Research, LACDR/Toxicology, Leiden University, PO Box 9500, 2300 RA, Leiden, The Netherlands., Leist M; In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany. marcel.leist@uni-konstanz.de.; CAAT Europe, University of Konstanz, Steinbeis SU-1866, 78457, Konstanz, Germany. marcel.leist@uni-konstanz.de.

Publikováno v: Archives of toxicology [Arch Toxicol] 2020 Jul; Vol. 94 (7), pp. 2435-2461. Date of Electronic Publication: 2020 Jul 06.