Switch from Type II to I Fas/CD95 Death Signaling on In Vitro Culturing of Primary Hepatocytes

Autor: Walter D, Schmich K, Vogel S, Pick R, Kaufmann T, Hochmuth FC, Haber A, Neubert K, McNelly S, von Weizsaecker F, Merfort I, MaUrer U, Strasser A, Borner C

Publikováno v: HEPATOLOGY

Fas/CD95 induced apoptosis of hepatocytes in vivo proceeds through the so called type II pathway requiring the proapoptotic BH3 only Bcl 2 family member Bid for mitochondrial death signaling. Consequently Bid deficient mice are protected from anti Fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=snsf_p3_pubs::3f644e3af0db087c7e7287d1564aa24e
http://www.pki.unibe.ch/content/research/research_groups/group_kaufmann/publications/

Modulating the dynamics of NFκB and PI3K enhances the ensemble-level TNFR1 signaling mediated apoptotic response.

Autor: Sherekar, Shubhank¹ (AUTHOR), Todankar, Chaitra S.¹ (AUTHOR), Viswanathan, Ganesh A.¹ (AUTHOR) ganeshav@iitb.ac.in

Publikováno v: NPJ Systems Biology & Applications. 11/16/2023, Vol. 9 Issue 1, p1-13. 13p.

Metabolomics analysis of mycelial exudates provides insights into fungal antagonists of Armillaria.

Autor: Zhan, Jian¹ (AUTHOR), Yuan, Jing¹ (AUTHOR), Liu, Jianwei¹ (AUTHOR), Zhang, Fengming¹ (AUTHOR), Yu, Fuqiang¹ (AUTHOR) fqyu@mail.kib.ac.cn, Wang, Yanliang¹ (AUTHOR) wangyanliang@mail.kib.ac.cn

Publikováno v: Mycology: An International Journal on Fungal Biology. Sep2023, Vol. 14 Issue 3, p264-274. 11p.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Autor: Godoy P; Leibniz Research Centre for Working Environment and Human Factors (IFADO), 44139, Dortmund, Germany., Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG

Publikováno v: Archives of toxicology [Arch Toxicol] 2013 Aug; Vol. 87 (8), pp. 1315-530. Date of Electronic Publication: 2013 Aug 23.

Modeling the TNFα-induced apoptosis pathway in hepatocytes.

Autor: Schlatter R; Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany., Schmich K, Lutz A, Trefzger J, Sawodny O, Ederer M, Merfort I

Publikováno v: PloS one [PLoS One] 2011 Apr 20; Vol. 6 (4), pp. e18646. Date of Electronic Publication: 2011 Apr 20.