PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma.

Autor: Garces de Los Fayos Alonso I; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria.; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Zujo L; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria.; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.; Division of Nuclear Medicine, Medical University of Vienna, 1090, Vienna, Austria., Wiest I; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria.; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.; Division of Nuclear Medicine, Medical University of Vienna, 1090, Vienna, Austria., Kodajova P; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Timelthaler G; Center for Cancer Research, Medical University of Vienna, 1090, Vienna, Austria., Edtmayer S; Division Pharmacology, Department of Pharmacology, Physiology and Microbiology, Karl Landsteiner University of Health Sciences, 3500, Krems, Austria., Zrimšek M; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria., Kollmann S; Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Giordano C; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria., Kothmayer M; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria.; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.; Centre for Anatomy and Cell Biology, Medical University of Vienna, 1090, Vienna, Austria., Neubauer HA; Institute of Animal Breeding and Genetics, Unit of Functional Cancer Genomics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Dey S; Department of Dermatology, Medical University of Graz, 8036, Graz, Austria.; Center for Medical Research (ZMF), Medical University of Graz, 8010, Graz, Austria., Schlederer M; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria., Schmalzbauer BS; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.; Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Limberger T; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria.; Division of Nuclear Medicine, Medical University of Vienna, 1090, Vienna, Austria.; CBMed Core Lab, Medical University of Vienna, 1090, Vienna, Austria., Probst C; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria.; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.; Division of Nuclear Medicine, Medical University of Vienna, 1090, Vienna, Austria., Pusch O; Centre for Anatomy and Cell Biology, Medical University of Vienna, 1090, Vienna, Austria., Högler S; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Tangermann S; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Merkel O; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria., Schiefer AI; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria., Kornauth C; Department of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090, Vienna, Austria.; Comprehensive Cancer Center Vienna, Vienna General Hospital, Medical University of Vienna, 1090, Vienna, Austria., Prutsch N; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Zimmerman M; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Abraham B; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Anagnostopoulos J; Institute of Pathology, University of Wuerzburg, 97080, Würzburg, Germany.; Institute of Pathology, Charité-Medical University of Berlin, 10117, Berlin, Germany., Quintanilla-Martinez L; Institute of Pathology and Neuropathology and Cluster of excellence iFIT, 'Image-Guided and Functionally Instructed Tumor Therapy', University of Tübingen, 72076, Tübingen, Germany., Mathas S; Department of Hematology, Oncology, and Cancer Immunology, Charité-Medical University of Berlin, 12200, Berlin, Germany.; German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Max-Delbrück-Center (MDC) for Molecular Medicine, 13125, Berlin, Germany.; Experimental and Clinical Research Center, a joint cooperation between the Charité and the MDC, 13125, Berlin, Germany., Wolf P; Department of Dermatology, Medical University of Graz, 8036, Graz, Austria., Stoiber D; Division Pharmacology, Department of Pharmacology, Physiology and Microbiology, Karl Landsteiner University of Health Sciences, 3500, Krems, Austria., Staber PB; Department of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090, Vienna, Austria.; Comprehensive Cancer Center Vienna, Vienna General Hospital, Medical University of Vienna, 1090, Vienna, Austria., Egger G; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria.; Comprehensive Cancer Center Vienna, Vienna General Hospital, Medical University of Vienna, 1090, Vienna, Austria.; Boltzmann Institute Applied Diagnostics, 1090, Vienna, Austria., Klapper W; Department of Pathology, Hematopathology Section and Lymph Node Registry, University of Kiel/University Hospital Schleswig-Holstein, 24105, Kiel, Germany., Woessmann W; Pediatric Hematology and Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Look TA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Gunning P; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, ON, L5L 1C6, Canada.; Department of Chemistry, University of Toronto, Toronto, ON, M5S 3H6, Canada., Turner SD; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, CB20QQ, UK.; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic., Moriggl R; Institute of Animal Breeding and Genetics, Unit of Functional Cancer Genomics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Lagger S; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Kenner L; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria. Lukas.kenner@meduniwien.ac.at.; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria. Lukas.kenner@meduniwien.ac.at.; Division of Nuclear Medicine, Medical University of Vienna, 1090, Vienna, Austria. Lukas.kenner@meduniwien.ac.at.; Center for Medical Research (ZMF), Medical University of Graz, 8010, Graz, Austria. Lukas.kenner@meduniwien.ac.at.; CBMed Core Lab, Medical University of Vienna, 1090, Vienna, Austria. Lukas.kenner@meduniwien.ac.at.; Christian Doppler Laboratory of Applied Metabolomics, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, 1090, Vienna, Austria. Lukas.kenner@meduniwien.ac.at.

Publikováno v: Molecular cancer [Mol Cancer] 2022 Aug 31; Vol. 21 (1), pp. 172. Date of Electronic Publication: 2022 Aug 31.

CDK6 Degradation Is Counteracted by p16 ^INK4A and p18 ^INK4C in AML.

Autor: Schmalzbauer BS; Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Thondanpallil T; Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Heller G; Division of Oncology, Department of Medicine I, Medical University of Vienna, 1090 Vienna, Austria., Schirripa A; Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Sperl CM; Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Mayer IM; Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Knab VM; Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Nebenfuehr S; Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Zojer M; Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Mueller AC; CeMM-Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria., Fontaine F; CeMM-Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria., Klampfl T; Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Sexl V; Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Kollmann K; Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.

Publikováno v: Cancers [Cancers (Basel)] 2022 Mar 18; Vol. 14 (6). Date of Electronic Publication: 2022 Mar 18.