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Boroleucine‐Derived Covalent Inhibitors of the ZIKV Protease.

Autor: Braun, Niklas J., Huber, Simon, Schmacke, Luna C., Heine, Andreas, Steinmetzer, Torsten

Publikováno v: ChemMedChem; Feb2023, Vol. 18 Issue 3, p1-8, 8p

A molecular mechanism to diversify Ca ²⁺ signaling downstream of Gs protein-coupled receptors.

Autor: Brands J; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.; Research Training Group 1873, University of Bonn, Bonn, Germany., Bravo S; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany., Jürgenliemke L; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.; Research Training Group 2873, University of Bonn, Bonn, Germany., Grätz L; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Schihada H; Department of Pharmaceutical Chemistry, Philipps-University Marburg, Marburg, Germany., Frechen F; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Alenfelder J; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany., Pfeil C; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.; Research Training Group 1873, University of Bonn, Bonn, Germany.; Amsterdam Institute for Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Ohse PG; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany., Hiratsuka S; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan., Kawakami K; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.; Komaba Institute for Science, The University of Tokyo, Meguro, Tokyo, 153-8505, Japan., Schmacke LC; Department of Pharmaceutical Chemistry, Philipps-University Marburg, Marburg, Germany., Heycke N; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany., Inoue A; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606-8501, Japan., König G; Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany., Pfeifer A; Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany., Wachten D; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Schulte G; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Steinmetzer T; Department of Pharmaceutical Chemistry, Philipps-University Marburg, Marburg, Germany., Watts VJ; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute of Drug Discovery, Purdue University, West Lafayette, IN, USA., Gomeza J; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany., Simon K; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131, Padova, Italy., Kostenis E; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany. kostenis@uni-bonn.de.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 03; Vol. 15 (1), pp. 7684. Date of Electronic Publication: 2024 Sep 03.