Genetic Inhibition of Serum Glucocorticoid Kinase 1 Prevents Obesity-related Atrial Fibrillation

Autor: Xin Yang, Matthias Nahrendorf, Anthony Rosenzweig, Ling Xiao, Schloss Mj, Yoshiko Iwamoto, Patrick T. Ellinor, Tedeschi J, Saumya Das, Maarten Hulsmans, Aneesh Bapat, David J. Milan, Gene-Wei Li

RationaleGiven its rising prevalence in both the adult and pediatric populations, obesity has become an increasingly important risk factor in the development of atrial fibrillation. However, a better mechanistic understanding of obesity-related atria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d58618336f8331975b08d529f2ad847
https://doi.org/10.1101/2021.05.20.444790

Therapeutic Spp1 silencing in TREM2 ⁺ cardiac macrophages suppresses atrial fibrillation.

Autor: Momin N; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Center for Precision Engineering for Health, University of Pennsylvania, Philadelphia, PA, USA., Pabel S; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany., Rudra A; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA., Kumowski N; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Lee IH; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Blavatnik Institute, Genetics, Harvard Medical School, Boston, MA, USA., Mentkowski K; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Yamazoe M; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Stengel L; Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany., Muse CG; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Seung H; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Paccalet A; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Gonzalez-Correa C; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Jacobs EB; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Center for Precision Engineering for Health, University of Pennsylvania, Philadelphia, PA, USA., Grune J; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Schloss MJ; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Sossalla S; Department of Cardiology, University Hospital Giessen, Kerckhoff Clinic Bad Nauheim, and DZHK, Partner site RhineMain, Germany., Wojtkiewicz G; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Iwamoto Y; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., McMullen P; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA., Mitchell RN; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Ellinor PT; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Anderson DG; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA., Naxerova K; Blavatnik Institute, Genetics, Harvard Medical School, Boston, MA, USA., Nahrendorf M; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Internal Medicine I, University Hospital Wuerzburg, Wuerzburg, Germany., Hulsmans M; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 10. Date of Electronic Publication: 2024 Aug 10.

Recruited macrophages elicit atrial fibrillation.

Autor: Hulsmans M; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Schloss MJ; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Lee IH; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Bapat A; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Iwamoto Y; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Vinegoni C; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Paccalet A; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Yamazoe M; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Grune J; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Pabel S; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany., Momin N; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Seung H; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Kumowski N; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Pulous FE; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Keller D; Department of Thoracic and Cardiovascular Surgery, University Hospital Wuerzburg, Wuerzburg, Germany., Bening C; Department of Thoracic and Cardiovascular Surgery, University Hospital Wuerzburg, Wuerzburg, Germany., Green U; Department of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Lennerz JK; Department of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Mitchell RN; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Lewis A; Radcliffe Department of Medicine, NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.; British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, UK., Casadei B; Radcliffe Department of Medicine, NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.; British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, UK., Iborra-Egea O; Institut del Cor Germans Trias i Pujol, CIBERCV, Badalona, Barcelona, Spain., Bayes-Genis A; Institut del Cor Germans Trias i Pujol, CIBERCV, Badalona, Barcelona, Spain., Sossalla S; Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.; Department of Cardiology and Angiology, University of Giessen/DZHK, Partner Site Rhein-Main, Germany., Ong CS; Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Surgery, Yale School of Medicine, New Haven, CT, USA., Pierson RN; Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Aster JC; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Rohde D; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Wojtkiewicz GR; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Weissleder R; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Swirski FK; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tellides G; Department of Surgery, Yale School of Medicine, New Haven, CT, USA., Tolis G Jr; Department of Cardiac Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Melnitchouk S; Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Milan DJ; Leducq Foundation, Boston, MA, USA., Ellinor PT; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Naxerova K; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Nahrendorf M; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Internal Medicine I, University Hospital Wuerzburg, Wuerzburg, Germany.

Publikováno v: Science (New York, N.Y.) [Science] 2023 Jul 14; Vol. 381 (6654), pp. 231-239. Date of Electronic Publication: 2023 Jul 13.

Genetic inhibition of serum glucocorticoid kinase 1 prevents obesity-related atrial fibrillation.

Autor: Bapat A; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Demoulas Family Foundation Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, Massachusetts, USA., Li G; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Xiao L; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Yeri A; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Hulsmans M; Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts, USA.; Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA., Grune J; Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts, USA.; Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.; German Centre for Cardiovascular Research, Berlin, Germany., Yamazoe M; Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts, USA.; Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA., Schloss MJ; Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts, USA.; Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA., Iwamoto Y; Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts, USA.; Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA., Tedeschi J; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Yang X; Fangshan Hospital of Beijing, University of Traditional Chinese Medicine, Beijing, China., Nahrendorf M; Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts, USA.; Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Internal Medicine I, University Hospital Wuerzburg, Wuerzburg, Germany., Rosenzweig A; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Ellinor PT; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Demoulas Family Foundation Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, Massachusetts, USA., Das S; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Demoulas Family Foundation Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, Massachusetts, USA., Milan D; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Leducq Foundation, Boston, Massachusetts, USA.

Publikováno v: JCI insight [JCI Insight] 2022 Oct 10; Vol. 7 (19). Date of Electronic Publication: 2022 Oct 10.

Neutrophils incite and macrophages avert electrical storm after myocardial infarction.

Autor: Grune J; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Lewis AJM; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; These authors contributed equally and are listed in alphabetical order: Andrew J. M. Lewis, Masahiro Yamazoe., Yamazoe M; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; These authors contributed equally and are listed in alphabetical order: Andrew J. M. Lewis, Masahiro Yamazoe., Hulsmans M; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Rohde D; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Xiao L; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Zhang S; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Ott C; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany., Calcagno DM; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Zhou Y; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Timm K; Department of Pharmacology, University of Oxford, Oxford, UK., Shanmuganathan M; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; National Institute for Health (NIHR) Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Pulous FE; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Schloss MJ; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Foy BH; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Capen D; Program in Membrane Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Vinegoni C; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Wojtkiewicz GR; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Iwamoto Y; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Grune T; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany., Brown D; Program in Membrane Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Higgins J; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Ferreira VM; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Herring N; National Institute for Health (NIHR) Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Channon KM; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; National Institute for Health (NIHR) Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Neubauer S; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; National Institute for Health (NIHR) Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Sosnovik DE; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Milan DJ; Leducq Foundation, Boston, MA, USA., Swirski FK; Cardiovascular Research Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., King KR; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.; Department of Medicine, Division of Cardiovascular Medicine, University of California, San Diego La Jolla, CA, USA., Aguirre AD; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ellinor PT; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nahrendorf M; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Internal Medicine, University Hospital Wuerzburg, Wuerzburg, Germany.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2022 Jul; Vol. 1 (7), pp. 649-664. Date of Electronic Publication: 2022 Jul 11.