Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling

Autor: Schiller CB, Lammens K, Guerini I, Coordes B, Feldmann H, Schlauderer F, Mxf6ckel C, Schele A, Strxe4sser K, Jackson SP, Hopfner KP.

Publikováno v: Nature Structural and Molecular Biology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=erc_________::472d722b57a4ed37e41e70c9c9d7d0f3

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses.

Autor: Napolitano V; Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany., Dabrowska A; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland., Schorpp K; Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany., Mourão A; Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany., Barreto-Duran E; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland., Benedyk M; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland., Botwina P; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland., Brandner S; Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany., Bostock M; Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany; Bavarian NMR Center, Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, 85748 Garching, Germany., Chykunova Y; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland., Czarna A; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland., Dubin G; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland., Fröhlich T; Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany., Hölscher M; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Leopoldstrasse 5, 80802 Munich, Germany., Jedrysik M; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland., Matsuda A; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland., Owczarek K; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland., Pachota M; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland., Plettenburg O; Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany; Centre of Biomolecular Drug Research (BMWZ), Institute of Organic Chemistry, Leibniz Universität Hannover, Hannover, Germany; Institute for Lung Health (ILH), Justus Liebig University, Giessen, Germany., Potempa J; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland., Rothenaigner I; Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany., Schlauderer F; Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany., Slysz K; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland., Szczepanski A; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland., Greve-Isdahl Mohn K; Haukeland University Hospital, Bergen, Norway., Blomberg B; Haukeland University Hospital, Bergen, Norway., Sattler M; Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany; Bavarian NMR Center, Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, 85748 Garching, Germany. Electronic address: sattler@helmholtz-muenchen.de., Hadian K; Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany. Electronic address: kamyar.hadian@helmholtz-muenchen.de., Popowicz GM; Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany; Bavarian NMR Center, Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, 85748 Garching, Germany. Electronic address: grzegorz.popowicz@helmholtz-muenchen.de., Pyrc K; Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland. Electronic address: k.a.pyrc@uj.edu.pl.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2022 May 19; Vol. 29 (5), pp. 774-784.e8. Date of Electronic Publication: 2022 Jan 11.