Multicenter Evaluation of Circulating Cell-Free DNA Extraction and Downstream Analyses for the Development of Standardized (Pre)analytical Work Flows

Autor: Lampignano , R., Neumann, M., Weber, S., Kloten, V., Herdean, A., Voss, T., Groelz, D., Babayan, A., Tibbesma, M., Schlumpberger, M., Chemi, F., Rothwell, D., Wikman, H., Galizzi, J., Bergheim, I., Russnes, H., Mussolin, B., Bonin, S., Voigt, C., Musa, H., Pinzani, P., Lianidou, E., Brady, G., Speicher, M., Pantel, K., Betsou, F., Schuuring, E., Kubista, M., Ammerlaan, W., Sprenger-Haussels, M., Schlange, T., Heitzer, E., Lehrach, H., Yaspo, M.

Publikováno v: Clinical Chemistry : International Journal of Molecular Diagnostics and Laboratory Medicine
Clinical Chemistry
Clinical Chemistry, 66(1), 149-160. AMER ASSOC CLINICAL CHEMISTRY

BACKGROUNDIn cancer patients, circulating cell-free DNA (ccfDNA) can contain tumor-derived DNA (ctDNA), which enables noninvasive diagnosis, real-time monitoring, and treatment susceptibility testing. However, ctDNA fractions are highly variable, whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49907e8af53f9610c711a42c26a883cb
https://hdl.handle.net/10453/145203

P094 A Phase II study to evaluate the safety, tolerability, pharmacodynamics and pharmacokinetics of BI 1291583 in patients with cystic fibrosis bronchiectasis (the Clairafly™ study)

Autor: Mall, M.A., Sauter, W., Davies, J.C., Donaldson, S., Eleftheraki, A., Sarubbi, D., Schlange, T., Jain, R., Rubin, B.K., Chalmers, J.D.

Publikováno v: In Journal of Cystic Fibrosis June 2023 22 Supplement 2:S92-S92

Multicenter evaluation of circulating plasma microRNA extraction technologies for the development of clinically feasible reverse transcription quantitative PCR and next-generation sequencing analytical work flows

Autor: Kloten, V. Neumann, M.H.D. Pasquale, F.D. Sprenger-Haussels, M. Shaffer, J.M. Schlumpberger, M. Herdean, A. Betsou, F. Ammerlaan, W. af Hällström, T. Serkkola, E. Forsman, T. Lianidou, E. Sjöback, R. Kubista, M. Bender, S. Lampignano, R. Krahn, T. Schlange, T. for the CANCER-ID consortium

BACKGROUND: In human body fluids, microRNA (miRNA) can be found as circulating cell-free miRNA (cfmiRNA), as well as secreted into extracellular vesicles (EVmiRNA). miRNAs are being intensively evaluated as minimally invasive liquid biopsy biomarkers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::98888ce4135a25d2f6a115ee7a31f739
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3077593

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Standardization of technologies for CTC, ctDNA and miRNA enrichment, isolation and analysis for liquid biopsies during the first year of IMI’s CANCER-ID

Autor: Schlange, T., Stoecklein, N.H., Neves, R.P., Pleier, S., Bender, Sabrina, Brychta, N., Luetke-Eversloh, M.V., Andree, Kiki Carlijn, Terstappen, Leonardus Wendelinus Mathias Marie, Krahn, T.

Publikováno v: ISSUE=107;TITLE=107th AACR Annual Meeting 2016

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::c3e53ba63f171260da094862c92cf023
https://research.utwente.nl/en/publications/standardization-of-technologies-for-ctc-ctdna-and-mirna-enrichment-isolation-and-analysis-for-liquid-biopsies-during-the-first-year-of-imis-cancerid(8c1e5f34-dec1-4d93-a06c-7d7d89635ddc).html