Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Schlama, A"'
Autor:
Gil, Victor Sabanza, Bran, Andres M., Franke, Malte, Schlama, Remi, Luterbacher, Jeremy S., Schwaller, Philippe
The prediction of chemical reactions has gained significant interest within the machine learning community in recent years, owing to its complexity and crucial applications in chemistry. However, model evaluation for this task has been mostly limited
Externí odkaz:
http://arxiv.org/abs/2312.09004
Autor:
Elina Siirola, Fabian Eggimann, Charles Moore, Kirsten Schroer, Alexandra Vargas, Theo Peschke, Thierry Schlama, Radka Snajdrova
Publikováno v:
CHIMIA, Vol 77, Iss 6 (2023)
The fortieth anniversary of biocatalysis started at Ciba-Geigy and later at Novartis is a great time to pause and reflect on development of science and technology in this field. Enzyme-based synthesis became a highly valued enabling tool for pharmace
Externí odkaz:
https://doaj.org/article/3d30ebe868c74ebe81b48aa586696c7b
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Arndt Meyer, Daniel Baeschlin, Cara E. Brocklehurst, Myriam Duckely, Fabrice Gallou, Lucie E. Lovelle, Michael Parmentier, Thierry Schlama, Radka Snajdrova, Yves P. Auberson
Publikováno v:
CHIMIA, Vol 75, Iss 11, Pp 936-942 (2021)
We present a short overview of the way Novartis chemists interact and collaborate with the academic chemistry community in Switzerland. This article exemplifies a number of collaborations, and illustrates opportunities to foster research synergies be
Externí odkaz:
https://doaj.org/article/0be771cd20a34e51afe795c8508edda4
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Fei Zhongbo, Darija Dedic, Philipp Lustenberger, Ueli Rüegger, Christian Mathes, Matthias Napp, Kurt Königsberger, Bernard Riss, Thierry Schlama, Glen Dempsey, Carolien den Reijer, Lukas Hueber
Publikováno v:
European Journal of Organic Chemistry. 2021:4490-4494
A novel and concise synthesis towards DP2 receptor antagonist Fevipiprant (NVS-QAW039) was developed. The initial research route was suffering from lengthy access to the functionalized 7-aza-indole core followed by a low selective N(1)-alkylation wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39251ab8b96d07356ed454b446027b76
https://doi.org/10.1002/ejoc.202100686
https://doi.org/10.1002/ejoc.202100686
Publikováno v:
Biocatalysis for Practitioners
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63c84e68526d72832e5a1dd46808199c
https://doi.org/10.1002/9783527824465.ch15
https://doi.org/10.1002/9783527824465.ch15
Autor:
Charlene Ching, Abigail Bautista, Oscar Alvizo, David Entwistle, Scott J. Novick, Florian Kleinbeck, Thomas Ruch, Dellas Nikki, David Homan, Garcia Ravi David, Thierry Schlama
Publikováno v:
ACS Catalysis. 11:3762-3770
An amine transaminase was engineered for the efficient production of a chiral precursor to sacubitril, (2R,4S)-5-([1,1′-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid, a key component in the blockb...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d257be1ac0d37e4f6d25601725e1981
https://doi.org/10.1021/acscatal.0c05450
https://doi.org/10.1021/acscatal.0c05450
Autor:
Alexandre Grand-Guillaume Perrenoud, Julien Haber, Florian Andreas Rampf, Van Tong Luu, Roger Humair, Wietfeld Bernhard, Michael Kibiger, Thomas Ruch, Lukas Padeste, Tao Hong, Pascal Beney, Yao Yang, Anikó Udvarhelyi, Leo A. Hardegger, Eric Sidler, Andreas Kaegi, Xingxian Gu, Dominique Bixel, Christian Fleury, Feng Gao, Thierry Schlama, Florian Kleinbeck
Publikováno v:
Organic Process Research & Development. 24:1763-1771
A process using an engineered phenylalanine ammonia lyase (PAL) enzyme was developed as part of an alternative route to a key intermediate of olodanrigan (EMA401). In the first part of this report,...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95a687930f6f0ddd829a4ff619f0423a
https://doi.org/10.1021/acs.oprd.0c00217
https://doi.org/10.1021/acs.oprd.0c00217
Autor:
Mann, Greg, Stanger, Frédéric V., Peschke, Theo, Schroer, Kirsten, Trung, Nhat Quang Nguyen, Burrer, Nathalie, Grassinger, Franziska, Piccioni, Lorenzo, Erdogan, Oemer, Heimburger, Jeremy, Koehl, Hervé, Ertle, Heike, Denay, Regis, Dreier, Philippe, Schlama, Thierry
Publikováno v:
In Tetrahedron Letters 16 March 2022 93