A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.

Autor: Brenner D; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany.; Department of Neurology, University of Ulm, Ulm, Germany., Sieverding K; Department of Neurology, University of Ulm, Ulm, Germany., Srinidhi J; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Zellner S; Medical Faculty, Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-University München , Munich, Germany., Secker C; Neuroproteomics, Max Delbrück Center for Molecular Medicine, Berlin, Germany.; Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Yilmaz R; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Dyckow J; Division of Neuroimmunology, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Amr S; Faculty of Medicine, Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt, Germany., Ponomarenko A; Department of Neurology, University of Ulm, Ulm, Germany.; Institute of Anatomy and Cell Biology, Ulm University School of Medicine , Ulm, Germany., Tunaboylu E; Department of Neurology, University of Ulm, Ulm, Germany., Douahem Y; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Schlag JS; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Rodríguez Martínez L; Institute of Neuronal Cell Biology, Technical University Munich , Munich, Germany.; German Center for Neurodegenerative Diseases , Munich, Germany., Kislinger G; Electron Microscopy Hub, German Center for Neurodegenerative Diseases, Munich, Germany., Niemann C; Electron Microscopy Hub, German Center for Neurodegenerative Diseases, Munich, Germany., Nalbach K; Medical Faculty, Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-University München , Munich, Germany., Ruf WP; Department of Neurology, University of Ulm, Ulm, Germany., Uhl J; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Hollenbeck J; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Schirmer L; Division of Neuroimmunology, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Catanese A; Institute of Anatomy and Cell Biology, Ulm University School of Medicine , Ulm, Germany., Lobsiger CS; Institut du Cerveau-Paris Brain Institute-Institut du Cerveau et de la Moelle épinière, Inserm, Centre National de la Recherche Scientifique, Assistance Publique-Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, Sorbonne Université , Paris, France., Danzer KM; Department of Neurology, University of Ulm, Ulm, Germany.; German Center for Neurodegenerative Diseases , Ulm, Germany., Yilmazer-Hanke D; Department of Neurology, Clinical Neuroanatomy Unit, University of Ulm, Ulm, Germany., Münch C; Institute of Anatomy and Cell Biology, Ulm University School of Medicine , Ulm, Germany., Koch P; University of Heidelberg/Medical Faculty Mannheim, Central Institute of Mental Health, Mannheim, Germany.; Hector Institute for Translational Brain Research , Mannheim, Germany.; German Cancer Research Center , Heidelberg, Germany., Freischmidt A; Department of Neurology, University of Ulm, Ulm, Germany., Fetting M; Medical Faculty, Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-University München , Munich, Germany.; Electron Microscopy Hub, German Center for Neurodegenerative Diseases, Munich, Germany., Behrends C; Medical Faculty, Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-University München , Munich, Germany., Parlato R; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany., Weishaupt JH; Division of Neurodegeneration, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2024 May 06; Vol. 221 (5). Date of Electronic Publication: 2024 Mar 22.