Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia:The COVID STEROID 2 Randomized Trial

Autor: Munch, Marie W, Myatra, Sheila N, Vijayaraghavan, Bharath Kumar Tirupakuzhi, Saseedharan, Sanjith, Benfield, Thomas, Wahlin, Rebecka R, Rasmussen, Bodil S, Andreasen, Anne Sofie, Poulsen, Lone M, Cioccari, Luca, Khan, Mohd S, Kapadia, Farhad, Divatia, Jigeeshu V, Br��chner, Anne C, Bestle, Morten H, Helleberg, Marie, Michelsen, Jens, Padmanaban, Ajay, Bose, Neeta, M��ller, Anders, Borawake, Kapil, Kristiansen, Klaus T, Shukla, Urvi, Chew, Michelle S, Dixit, Subhal, Ulrik, Charlotte S, Amin, Pravin R, Chawla, Rajesh, Wamberg, Christian A, Shah, Mehul S, Darfelt, Iben S, J��rgensen, Vibeke L, Smitt, Margit, Granholm, Anders, Kj��r, Maj-Brit N, M��ller, Morten H, Meyhoff, Tine S, Vesterlund, Gitte K, Hammond, Naomi E, Micallef, Sharon, Bassi, Abhinav, John, Oommen, Jha, Anubhuti, Cronhjort, Maria, Jakob, Stephan M, Gluud, Christian, Lange, Theis, Kadam, Vaijayanti, Marcussen, Klaus V, Hollenberg, Jacob, Hedman, Anders, Nielsen, Henrik, Schj��rring, Olav L, Jensen, Marie Q, Leistner, Jens W, Jonassen, Trine B, Kristensen, Camilla M, Clapp, Esben C, Hjorts��, Carl J S, Jensen, Thomas S, Halstad, Liv S, Bak, Emilie R B, Zaabalawi, Reem, Metcalf-Clausen, Matias, Abdi, Suhayb, Hatley, Emma V, Aksnes, Tobias S, Gleipner-Andersen, Emil, Alarc��n, Arif F, Yamin, Gabriel, Heymowski, Adam, Berggren, Anton, La Cour, Kirstine, Weihe, Sarah, Pind, Alison H, Engstr��m, Janus, Jha, Vivekanand, Venkatesh, Balasubramanian, Perner, Anders

Publikováno v: COVID STEROID 2 Trial Group, Rasmussen, B S, Nielsen, H & Schjørring, O L 2021, ' Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia : The COVID STEROID 2 Randomized Trial ', JAMA: The Journal of the American Medical Association, vol. 326, no. 18, pp. 1807-1817 . https://doi.org/10.1001/jama.2021.18295
Munch, M W, Myatra, S N, Vijayaraghavan, B K T, Saseedharan, S, Benfield, T, Wahlin, R R, Rasmussen, B S, Andreasen, A S, Poulsen, L M, Cioccari, L, Khan, M S, Kapadia, F, Divatia, J V, Brochner, A C, Bestle, M H, Helleberg, M, Michelsen, J, Padmanaban, A, Bose, N, Møller, A, Borawake, K, Kristiansen, K T, Shukla, U, Chew, M S, Dixit, S, Ulrik, C S, Amin, P R, Chawla, R, Wamberg, C A, Shah, M S, Darfelt, I S, Jorgensen, V L, Smitt, M, Granholm, A, Kjær, M-B N, Møller, M H, Meyhoff, T S, Vesterlund, G K, Hammond, N E, Micallef, S, Bassi, A, John, O, Jha, A, Cronhjort, M, Jakob, S M, Gluud, C, Lange, T, Kadam, V, Marcussen, K V, Hollenberg, J, Hedman, A, Nielsen, H, Schjorring, O L, Jensen, M Q, Leistner, J W, Jonassen, T B, Kristensen, C M, Clapp, E C, Hjortso, C J S, Jensen, T S, Halstad, L S, Bak, E R B, Zaabalawi, R, Metcalf-Clausen, M, Abdi, S, Hatley, E V, Aksnes, T S, Gleipner-Andersen, E, Alarcon, A F, Yamin, G, Heymowski, A, Berggren, A, La Cour, K, Weihe, S, Pind, A H, Engstrom, J, Jha, V, Venkatesh, B & Perner, A 2021, ' Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia The COVID STEROID 2 Randomized Trial ', J A M A: The Journal of the American Medical Association, vol. 326, no. 18, pp. 1807-1817 . https://doi.org/10.1001/jama.2021.18295
COVID STEROID 2 Trial Group 2021, ' Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia : The COVID STEROID 2 Randomized Trial ', JAMA: The Journal of the American Medical Association, vol. 326, no. 18, pp. 1807-1817 . https://doi.org/10.1001/jama.2021.18295
The COVID STEROID 2 Trial Group 2021, ' Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive without Life Support in Adults with COVID-19 and Severe Hypoxemia : The COVID STEROID 2 Randomized Trial ', JAMA-Journal of the American Medical Association, vol. 326, no. 18, pp. 1807-1817 . https://doi.org/10.1001/jama.2021.18295

Importance A daily dose with 6 mg of dexamethasone is recommended for up to 10 days in patients with severe and critical COVID-19, but a higher dose may benefit those with more severe disease. Objective To assess the effects of 12 mg/d vs 6 mg/d of d

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