Inhibition of circulating dipeptidyl-peptidase 3 by procizumab in experimental septic shock reduces catecholamine exposure and myocardial injury

Autor: Bruno Garcia, Benoit ter Schiphorst, Karine Santos, Fuhong Su, Laurence Dewachter, Francisco Vasques-Nóvoa, Estela Rocha-Oliveira, Roberto Roncon-Albuquerque, Theo Uba, Oliver Hartmann, Adrien Picod, Feriel Azibani, Jacques Callebert, Serge Goldman, Filippo Annoni, Raphaël Favory, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone, Alexandre Mebazaa, Antoine Herpain

Publikováno v: Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-13 (2024)

Abstract Background Dipeptidyl peptidase 3 (DPP3) is a ubiquitous cytosolic enzyme released into the bloodstream after tissue injury, that can degrade angiotensin II. High concentrations of circulating DPP3 (cDPP3) have been associated with worse out

Externí odkaz: https://doaj.org/article/26b2ee6ba727427889ab7b469a6a7906

Inhibition of circulating dipeptidyl-peptidase 3 by procizumab in experimental septic shock reduces catecholamine exposure and myocardial injury.

Autor: Garcia, Bruno^1,2 (AUTHOR) br.garcia@icloud.com, ter Schiphorst, Benoit^1,2 (AUTHOR), Santos, Karine³ (AUTHOR), Su, Fuhong¹ (AUTHOR), Dewachter, Laurence⁴ (AUTHOR), Vasques-Nóvoa, Francisco⁵ (AUTHOR), Rocha-Oliveira, Estela⁵ (AUTHOR), Roncon-Albuquerque Jr., Roberto⁵ (AUTHOR), Uba, Theo³ (AUTHOR), Hartmann, Oliver³ (AUTHOR), Picod, Adrien⁶ (AUTHOR), Azibani, Feriel⁶ (AUTHOR), Callebert, Jacques^6,7 (AUTHOR), Goldman, Serge⁸ (AUTHOR), Annoni, Filippo^1,9 (AUTHOR), Favory, Raphaël² (AUTHOR), Vincent, Jean-Louis^1,9 (AUTHOR), Creteur, Jacques^1,9 (AUTHOR), Taccone, Fabio Silvio^1,9 (AUTHOR), Mebazaa, Alexandre^6,10 (AUTHOR)

Publikováno v: Intensive Care Medicine Experimental. 6/7/2024, Vol. 12 Issue 1, p1-13. 13p.

In young patients with stroke of undetermined etiology, large vessel occlusions are less frequent in the group with high-risk patent foramen ovale

Autor: Ter Schiphorst, A., Lippi, A., Corti, L., Mourand, I., Prin, P., Agullo, A., Cagnazzo, F., Macia, J.-C., Arquizan, C.

Publikováno v: In Revue Neurologique June 2024 180(6):539-547

Natural Language Processing of Referral Letters for Machine Learning–Based Triaging of Patients With Low Back Pain to the Most Appropriate Intervention: Retrospective Study

Autor: Sebastian Fudickar, Carsten Bantel, Jannik Spieker, Heinrich Töpfer, Patrick Stegeman, Henrica R Schiphorst Preuper, Michiel F Reneman, André P Wolff, Remko Soer

Publikováno v: Journal of Medical Internet Research, Vol 26, p e46857 (2024)

BackgroundDecision support systems (DSSs) for suggesting optimal treatments for individual patients with low back pain (LBP) are currently insufficiently accurate for clinical application. Most of the input provided to train these systems is based on

Externí odkaz: https://doaj.org/article/791aa26900b847eb898c4fc04c21d535

Aspiration Versus Stent‐Retriever as First‐Line Endovascular Therapy Technique for Primary Medium and Distal Intracranial Occlusions: A Propensity‐Score Matched Multicenter Analysis

Autor: James E. Siegler, Hamza Shaikh, Jane Khalife, Solomon Oak, Linda Zhang, Mohamad Abdalkader, Piers Klein, Thanh N. Nguyen, Tareq Kass‐Hout, Rami Z. Morsi, Jeremy J. Heit, Robert W. Regenhardt, Jose Danilo Bengzon Diestro, Nicole M. Cancelliere, Sherief Ghozy, Ahmad Sweid, Kareem El Naamani, Abdelaziz Amllay, Lukas Meyer, Anne Dusart, Flavio Bellante, Géraud Forestier, Aymeric Rouchaud, Suzana Saleme, Charbel Mounayer, Jens Fiehler, Anna Luisa Kühn, Ajit S. Puri, Christian Dyzmann, Peter T. Kan, Marco Colasurdo, Gaultier Marnat, Jérôme Berge, Xavier Barreau, Igor Sibon, Simona Nedelcu, Nils Henninger, Thomas R. Marotta, Alvin S. Das, Christopher J. Stapleton, James D. Rabinov, Takahiro Ota, Shogo Dofuku, Leonard L.L. Yeo, Benjamin Y.Q. Tan, Juan Carlos Martinez‐Gutierrez, Sergio Salazar‐Marioni, Sunil A. Sheth, Leonardo Renieri, Carolina Capirossi, Ashkan Mowla, Stavropoula I. Tjoumakaris, Pascal Jabbour, Priyank Khandelwal, Arundhati Biswas, Frédéric Clarençon, Mahmoud Elhorany, Kevin Premat, Iacopo Valente, Alessandro Pedicelli, João Pedro Filipe, Ricardo Varela, Miguel Quintero‐Consuegra, Nestor R. Gonzalez, Markus A. Möhlenbruch, Jessica Jesser, Vincent Costalat, Adrien ter Schiphorst, Vivek Yedavalli, Pablo Harker, Lina M. Chervak, Yasmin Aziz, Maria Bres Bullrich, Luciano Sposato, Benjamin Gory, Constantin Hecker, Monika Killer‐Oberpfalzer, Christoph J. Griessenauer, Ajith J. Thomas, Cheng‐Yang Hsieh, David S. Liebeskind, Răzvan Alexandru Radu, Andrea M. Alexandre, Illario Tancredi, Tobias D. Faizy, Robert Fahed, Charlotte Weyland, Aman B. Patel, Vitor Mendes Pereira, Boris Lubicz, Adrien Guenego, Adam A. Dmytriw

Publikováno v: Stroke: Vascular and Interventional Neurology, Vol 3, Iss 6 (2023)

Background For acute proximal intracranial artery occlusions, contact aspiration may be more effective than stent‐retriever for first‐line reperfusion therapy. Due to the lack of data regarding medium vessel occlusion thrombectomy, we evaluated o

Externí odkaz: https://doaj.org/article/ba3e488b0a38477d9ab07c71dade0116