Výsledky vyhledávání - "Schins Roel PF"

Akademický článek

Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms

Autor: Schmidt Annette M, van Schooten Frederik-Jan, Haberzettl Petra, van Berlo Damiёn, Bushmelev Alexey, Langer Julia, Scherbart Agnes M, Rose Christine R, Schins Roel PF, Albrecht Catrin

Publikováno v: Particle and Fibre Toxicology, Vol 8, Iss 1, p 31 (2011)

Abstract Inhalation of (nano)particles may lead to pulmonary inflammation. However, the precise mechanisms of particle uptake and generation of inflammatory mediators by alveolar macrophages (AM) are still poorly understood. The aim of this study was

Externí odkaz: https://doaj.org/article/671147db01b14c24946ed69e31da1c0b

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Akademický článek

NF-κB dependent and independent mechanisms of quartz-induced proinflammatory activation of lung epithelial cells

Autor: Schins Roel PF, van Schooten Frederik-Jan, Knaapen Ad M, van Berlo Damien, Albrecht Catrin

Publikováno v: Particle and Fibre Toxicology, Vol 7, Iss 1, p 13 (2010)

Abstract In the initiation and progression of pulmonary inflammation, macrophages have classically been considered as a crucial cell type. However, evidence for the role of epithelial type II cells in pulmonary inflammation has been accumulating. In

Externí odkaz: https://doaj.org/article/7e22662d824a4929982ed1a967d6591c

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Akademický článek

Effect of prolonged exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain

Autor: Wang Kate, Schins Roel PF, Cassee Flemming R, van Berlo Damien, Gerlofs-Nijland Miriam E, Campbell Arezoo

Publikováno v: Particle and Fibre Toxicology, Vol 7, Iss 1, p 12 (2010)

Abstract Background The etiology and progression of neurodegenerative disorders depends on the interactions between a variety of factors including: aging, environmental exposures, and genetic susceptibility factors. Enhancement of proinflammatory eve

Externí odkaz: https://doaj.org/article/24173faae2804e6e845fb14ddea580a6

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Akademický článek

Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells

Autor: Schins Roel PF, Boertz Jens, Davoren Maria, Bhattacharya Kunal, Hoffmann Eik, Dopp Elke

Publikováno v: Particle and Fibre Toxicology, Vol 6, Iss 1, p 17 (2009)

Abstract Titanium dioxide (TiO2), also known as titanium (IV) oxide or anatase, is the naturally occurring oxide of titanium. It is also one of the most commercially used form. To date, no parameter has been set for the average ambient air concentrat

Externí odkaz: https://doaj.org/article/2a26487fd4ae42a1899a74bc4d667e5b

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Akademický článek

The crucial role of particle surface reactivity in respirable quartz-induced reactive oxygen/nitrogen species formation and APE/Ref-1 induction in rat lung

Autor: Haberzettl Petra, Höhr Doris, Becker Andrea, Knaapen Ad M, Albrecht Catrin, van Schooten Frederik J, Borm Paul JA, Schins Roel PF

Publikováno v: Respiratory Research, Vol 6, Iss 1, p 129 (2005)

Abstract Persistent inflammation and associated excessive oxidative stress have been crucially implicated in quartz-induced pulmonary diseases, including fibrosis and cancer. We have investigated the significance of the particle surface reactivity of

Externí odkaz: https://doaj.org/article/860462c00fe54cc7a67a7e12c5ad0abf

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