Zobrazeno 1 - 10
of 434
pro vyhledávání: '"Schinkel, AH"'
Autor:
van Waterschoot, RAB, ter Heine, R, Wagenaar, E, van der Kruijssen, CMM, Rooswinkel, RW, Huitema, ADR, Beijnen, JH, Schinkel, AH
Lopinavir is extensively metabolized by cytochrome P450 3A (CYP3A) and is considered to be a substrate for the drug transporters ABCB1 (P-glycoprotein) and ABCC2 (MRP2). Here, we have assessed the individual and combined effects of CYP3A, ABCB1 and A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aa6a357ddf483387a53f2579f536600a
https://europepmc.org/articles/PMC2936030/
https://europepmc.org/articles/PMC2936030/
Autor:
Deuster, D, Ciarimboli, G, Knief, A, Edemir, B, Pavenstädt, H, Lanvers-Kaminsky, C, Schinkel, AH, Jürgens, H, Schlatter, E, am Zehnhoff-Dinnesen, A
Publikováno v:
27. Wissenschaftliche Jahrestagung der Deutschen Gesellschaft für Phoniatrie und Pädaudiologie (DGPP); 20100917-20100919; Aachen; DOC10dgppV06 /20100831/
Einleitung Cisplatin ist ein wirksames Chemotherapeutikum für die Behandlung von Tumoren im Kindesalter, limitiert durch seine Oto- und Nephrotoxizität. Die individuell unterschiedliche Cisplatin-Toleranz spricht für das Vorhandensein genetischer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e89ad5fdd26655846f2ca32f630792f
Publikováno v:
Molecular Pharmacology, 63(4), 844-848. AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
Biguanides are a class of drugs widely used as oral antihyperglycemic agents for the treatment of type 2 diabetes mellitus, but they are associated with lactic acidosis, a lethal side effect. We reported previously that biguanides are good substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::10819ae363b4a154601dd93bb7c77a29
https://research.rug.nl/en/publications/e0e46aef-e2f5-4529-bb19-a3966280027f
https://research.rug.nl/en/publications/e0e46aef-e2f5-4529-bb19-a3966280027f
Publikováno v:
Hepatology, 32(4), 316A-316A. Wiley
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::fd73a6403620dce2cf9232887faded67
https://research.rug.nl/en/publications/1cf6a6d4-1723-4d16-9da0-f0b944011543
https://research.rug.nl/en/publications/1cf6a6d4-1723-4d16-9da0-f0b944011543
Autor:
Schellens, JHM, Maliepaard, M, Scheper, RJ, Scheffer, GL, Jonker, JW, Smit, JW, Beijnen, JH, Schinkel, AH, Liehr, JG, Giovanella, BC, Verschaegen, CF
Publikováno v:
CAMPTOTHECINS: UNFOLDING THEIR ANTICANER POTENTIAL, 188-194
STARTPAGE=188;ENDPAGE=194;TITLE=CAMPTOTHECINS: UNFOLDING THEIR ANTICANER POTENTIAL
STARTPAGE=188;ENDPAGE=194;TITLE=CAMPTOTHECINS: UNFOLDING THEIR ANTICANER POTENTIAL
The multidrug resistance protein BCRP (breast cancer resistance protein) is a member of the ATP-binding cassette family of drug transporters. Overexpression of BCRP caused by exposure of cells to mitoxantrone (MX) or doxorubicin/verapamil resulted in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::1b4ed4338f0de0d57919a0a6572b0d1c
https://research.rug.nl/en/publications/92a03833-7106-4db5-81f0-cb3a25760aa8
https://research.rug.nl/en/publications/92a03833-7106-4db5-81f0-cb3a25760aa8
Publikováno v:
Pharmaceutical Research, 15(11), 1657-1665. SPRINGER/PLENUM PUBLISHERS
Purpose. The effect of P-glycoprotein (Pgp) on brain distribution using mdr1a (-/-) mice was investigated. Methods. Fluorescein (Flu) and FD-4 were used to check whether blood-brain barrier (BBB) integrity was maintained in mdr1a (-/-) mice. The Pgp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::9bea4daefeeb89c5be263c0a27bd5314
https://research.rug.nl/en/publications/c8597563-f1e5-4229-8fea-5b0e2a7b3e48
https://research.rug.nl/en/publications/c8597563-f1e5-4229-8fea-5b0e2a7b3e48
Autor:
Hendrikse, NH, Schinkel, AH, De Vries, EGE, Fluks, E, Van der Graaf, WTA, Willemsen, ATM, Vaalburg, W, Franssen, EJF
Publikováno v:
British Journal of Pharmacology, 124(7), 1413-1418. Wiley-Blackwell
1 Homozygously mdr1a gene disrupted mice (mdr1a(-/-) mice) and wild type mice (mdr1a(+/+) mice) were used to develop a method for P-glycoprotein (P-gp) function imaging non-invasively and to study the effect of a P-gp reversal agent on its function i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::080f029061624e863b8119936a5a0151
https://research.rug.nl/en/publications/c65f61ef-23f5-4275-b6d2-8e3e1c00d7ba
https://research.rug.nl/en/publications/c65f61ef-23f5-4275-b6d2-8e3e1c00d7ba
Publikováno v:
Journal of Cellular Biochemistry, 99-99. Wiley-Blackwell
STARTPAGE=99;ENDPAGE=99;ISSN=0730-2312;TITLE=Journal of Cellular Biochemistry
STARTPAGE=99;ENDPAGE=99;ISSN=0730-2312;TITLE=Journal of Cellular Biochemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::37aeb6a5684ccdb621aefd669aaf0e93
https://research.rug.nl/en/publications/804a9f2c-8434-4021-ab66-143086856bf9
https://research.rug.nl/en/publications/804a9f2c-8434-4021-ab66-143086856bf9
Autor:
BORST, P, SCHINKEL, AH, SMIT, JJM, Wagenaar, E, VANDEEMTER, L, SMITH, AJ, EIJDEMS, EWHM, BAAS, F, ZAMAN, GJR
Publikováno v:
Pharmacology & Therapeutics, 60(2), 289-299. PERGAMON-ELSEVIER SCIENCE LTD
In this paper, we review recent work on multidrug resistance (MDR) in Amsterdam. We have generated mice homozygous for a disruption of one of their P-glycoprotein (Pgp) genes. The mutations do not interfere with viability or fertility, showing that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::e52e8840c8fb1265f3fe9a9dba7e91f8
https://research.rug.nl/en/publications/c8168ccd-b4d6-4ca9-afaf-4ca35834538b
https://research.rug.nl/en/publications/c8168ccd-b4d6-4ca9-afaf-4ca35834538b
Publikováno v:
Bioanalysis; Apr2014, Vol. 6 Issue 7, p993-1010, 18p
