Novel biosensor for high-throughput detection of progesterone receptor-interacting endocrine disruptors.

Autor: Stavreva DA; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, 41 Medlars Dr., Bethesda, MD, 20892-5055, USA. stavrevd@mail.nih.gov., Varticovski L; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, 41 Medlars Dr., Bethesda, MD, 20892-5055, USA., Raziuddin R; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, 41 Medlars Dr., Bethesda, MD, 20892-5055, USA., Pegoraro G; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, 41 Medlars Dr., Bethesda, MD, 20892-5055, USA., Schiltz RL; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, 41 Medlars Dr., Bethesda, MD, 20892-5055, USA., Hager GL; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, 41 Medlars Dr., Bethesda, MD, 20892-5055, USA. hagerg@exchange.nih.gov.

Publikováno v: Scientific reports [Sci Rep] 2024 Mar 06; Vol. 14 (1), pp. 5567. Date of Electronic Publication: 2024 Mar 06.

The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities.

Autor: Jiménez-Panizo A; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona (UB), 08028 Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona (UB), 08028 Barcelona, Spain.; National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-5055, USA., Alegre-Martí A; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona (UB), 08028 Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona (UB), 08028 Barcelona, Spain., Tettey TT; National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-5055, USA., Fettweis G; National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-5055, USA., Abella M; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona (UB), 08028 Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona (UB), 08028 Barcelona, Spain., Antón R; Biomedical Research Institute Sant Pau (IIB Sant Pau), 08041 Barcelona, Spain., Johnson TA; National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-5055, USA., Kim S; National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-5055, USA., Schiltz RL; National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-5055, USA., Núñez-Barrios I; Andalusian Center for Developmental Biology (CABD-CSIC). Campus Universitario Pablo de Olavide, 41013 Sevilla, Spain., Font-Díaz J; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona (UB), 08028 Barcelona, Spain.; Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain., Caelles C; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona (UB), 08028 Barcelona, Spain.; Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona 08028, Spain., Valledor AF; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona (UB), 08028 Barcelona, Spain.; Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain., Pérez P; Instituto de Biomedicina de Valencia (IBV)-CSIC, 46010, Valencia, Spain., Rojas AM; Andalusian Center for Developmental Biology (CABD-CSIC). Campus Universitario Pablo de Olavide, 41013 Sevilla, Spain., Fernández-Recio J; Instituto de Ciencias de la Vid y del Vino (ICVV), CSIC - Universidad de La Rioja - Gobierno de La Rioja, 26007 Logroño, Spain., Presman DM; IFIBYNE, UBA-CONICET, Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Buenos Aires C1428EGA, Argentina., Hager GL; National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-5055, USA., Fuentes-Prior P; Biomedical Research Institute Sant Pau (IIB Sant Pau), 08041 Barcelona, Spain., Estébanez-Perpiñá E; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona (UB), 08028 Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona (UB), 08028 Barcelona, Spain.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2022 Dec 09; Vol. 50 (22), pp. 13063-13082.

DNA binding triggers tetramerization of the glucocorticoid receptor in live cells

Autor: Diego M. Presman, Taccara Johnson, Tatiana S. Karpova, Schiltz Rl, Gordon L. Hager, Sourav Ganguly

Transcription factors dynamically bind to chromatin and are essential for the regulation of genes. Although a large percentage of these proteins appear to self-associate to form dimers or higher order oli gomers, t he stoichiometry of DNA-bound trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c739b54f2f3d929d8ec755aeb99dc9
https://europepmc.org/articles/PMC4961135/

PTEN depletion reduces H3K27me3 levels to promote epithelial-to-mesenchymal transition in epithelial colorectal cancer cells.

Autor: Ghobashi, Ahmed H.^1,2,3 (AUTHOR), Kimani, Jane W.² (AUTHOR), Ladaika, Christopher A.^1,2,3 (AUTHOR), O'Hagan, Heather M.^2,3,4 (AUTHOR) hmohagan@iu.edu

Publikováno v: PLoS ONE. 11/19/2024, Vol. 19 Issue 11, p1-23. 23p.

Valproic acid use is associated with diminished risk of contracting COVID-19, and diminished disease severity: Epidemiologic and in vitro analysis reveal mechanistic insights.

Autor: Watson, Amanda¹ (AUTHOR), Shah, Pankil² (AUTHOR), Lee, Doug² (AUTHOR), Liang, Sitai² (AUTHOR), Joshi, Geeta² (AUTHOR), Metitiri, Ediri² (AUTHOR), Chowdhury, Wasim H.² (AUTHOR), Bacich, Dean² (AUTHOR), Dube, Peter³ (AUTHOR), Xiang, Yan⁴ (AUTHOR), Hanley, Daniel⁵ (AUTHOR), Martinez-Sobrido, Luis⁶ (AUTHOR), Rodriguez, Ronald⁷ (AUTHOR) Rodriguezr32@uthscsa.edu

Publikováno v: PLoS ONE. 8/2/2024, Vol. 19 Issue 8, p1-28. 28p.