Highly Functionalized Terpyridines as Competitive Inhibitors of AKAP–PKA Interactions

Autor: Schäfer, Gesa, Milić, Jelena, Eldahshan, Adeeb, Götz, Frank, Zühlke, Kerstin, Schillinger, Christian, Kreuchwig, Annika, Elkins, Jonathan M., Azeez, Kamal R. Abdul, Oder, Andreas, Moutty, Marie C., Masada, Nanako, Beerbaum, Monika, Schlegel, Brigitte, Niquet, Sylvia, Schmieder, Peter, Krause, Gerd, von Kries, Jens Peter, Cooper, Dermot M. F., Knapp, Stefan, Rademann, Jörg, Rosenthal, Walter, Klussmann, Enno

Publikováno v: Angewandte Chemie, 52(46):12187–12191

A good fit: Interactions between A-kinase anchoring proteins (AKAPs) and protein kinase A (PKA) play key roles in a plethora of physiologically relevant processes whose dysregulation causes or is associated with diseases such as heart failure. Terpyr

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Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.

Autor: Schäfer G; Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Strasse 10, 13125 Berlin (Germany)., Milić J, Eldahshan A, Götz F, Zühlke K, Schillinger C, Kreuchwig A, Elkins JM, Abdul Azeez KR, Oder A, Moutty MC, Masada N, Beerbaum M, Schlegel B, Niquet S, Schmieder P, Krause G, von Kries JP, Cooper DM, Knapp S, Rademann J, Rosenthal W, Klussmann E

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2013 Nov 11; Vol. 52 (46), pp. 12187-91. Date of Electronic Publication: 2013 Sep 23.