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Scd1 and monounsaturated lipids are required for autophagy and survival of adipocytes.

Autor: Mori H; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: morimori@umich.edu., Peterson SK; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Simmermon RC; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Overmyer KA; Morgridge Institute for Research, Madison, WI, USA; National Center for Quantitative Biology of Complex Systems, Madison, WI, USA., Nishii A; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Paulsson E; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Li Z; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Jen A; Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI, USA; Department of Chemistry, University of Wisconsin, Madison, WI, USA., Uranga RM; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Maung JN; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Yacawych WT; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Lewis KT; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Schill RL; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Hetrick T; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Seino R; Dojindo Molecular Technologies, Inc., Rockville, MD, USA., Inoki K; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Coon JJ; Morgridge Institute for Research, Madison, WI, USA; National Center for Quantitative Biology of Complex Systems, Madison, WI, USA; Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI, USA; Department of Chemistry, University of Wisconsin, Madison, WI, USA., MacDougald OA; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: macdouga@umich.edu.

Publikováno v: Molecular metabolism [Mol Metab] 2024 May; Vol. 83, pp. 101916. Date of Electronic Publication: 2024 Mar 14.

TET3 plays a critical role in white adipose development and diet-induced remodeling.

Autor: Jung BC; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA., You D; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA., Lee I; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA., Li D; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., Schill RL; Department of Molecular & Integrative Physiology, University of Michigan School of Medicine, Ann Arbor, MO, USA., Ma K; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA., Pi A; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA., Song Z; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA., Mu WC; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA., Wang T; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., MacDougald OA; Department of Molecular & Integrative Physiology, University of Michigan School of Medicine, Ann Arbor, MO, USA., Banks AS; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA., Kang S; Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA. Electronic address: kangs@berkeley.edu.

Publikováno v: Cell reports [Cell Rep] 2023 Oct 31; Vol. 42 (10), pp. 113196. Date of Electronic Publication: 2023 Sep 30.

Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits.

Autor: Li Z; University of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States., Bowers E; University of Michigan Medical School, Department of Pediatrics, Ann Arbor, United States., Zhu J; Department of Orthopedic Surgery, University of Michigan Medical School, Ann Arbor, United States.; Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Yu H; University of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States., Hardij J; University of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States., Bagchi DP; University of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States., Mori H; University of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States., Lewis KT; University of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States., Granger K; University of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States., Schill RL; University of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States., Romanelli SM; University of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States., Abrishami S; University of Michigan Medical School, Department of Pediatrics, Ann Arbor, United States., Hankenson KD; Department of Orthopedic Surgery, University of Michigan Medical School, Ann Arbor, United States., Singer K; University of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States.; University of Michigan Medical School, Department of Pediatrics, Ann Arbor, United States., Rosen CJ; Maine Medical Center Research Institute, Scarborough, United States., MacDougald OA; University of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States.; University of Michigan Medical School, Department of Internal Medicine, Ann Arbor, United States.

Publikováno v: ELife [Elife] 2022 Jun 22; Vol. 11. Date of Electronic Publication: 2022 Jun 22.

Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake.

Autor: Xu H; Department of Medicine, Division of Endocrinology and Molecular Medicine (H.X., S.K., A.B.O., E.M., B.G., D.S., M.G.S.-T.), Medical College of Wisconsin, Milwaukee., Thomas MJ; Pharmacology & Toxicology (M.J.T., R.K., D.S., M.G.S.-T.), Medical College of Wisconsin, Milwaukee.; Cardiovascular Center (M.J.T., J.L.G., D.S., M.G.S.-T.), Medical College of Wisconsin, Milwaukee., Kaul S; Department of Medicine, Division of Endocrinology and Molecular Medicine (H.X., S.K., A.B.O., E.M., B.G., D.S., M.G.S.-T.), Medical College of Wisconsin, Milwaukee., Kallinger R; Pharmacology & Toxicology (M.J.T., R.K., D.S., M.G.S.-T.), Medical College of Wisconsin, Milwaukee., Ouweneel AB; Department of Medicine, Division of Endocrinology and Molecular Medicine (H.X., S.K., A.B.O., E.M., B.G., D.S., M.G.S.-T.), Medical College of Wisconsin, Milwaukee., Maruko E; Department of Medicine, Division of Endocrinology and Molecular Medicine (H.X., S.K., A.B.O., E.M., B.G., D.S., M.G.S.-T.), Medical College of Wisconsin, Milwaukee., Oussaada SM; Department of Endocrinology and Metabolism (S.M.O., M.J.S.), Amsterdam University Medical Centers, Academic Medical Center, the Netherlands., Jongejan A; Department of Bioinformatics (A.J.), Amsterdam University Medical Centers, Academic Medical Center, the Netherlands., Cense HA; Department of Surgery, Rode Kruis Ziekenhuis, Beverwijk, the Netherlands (H.A.C.)., Nieuwdorp M; Department of Internal and Vascular Medicine (M.N.), Amsterdam University Medical Centers, Academic Medical Center, the Netherlands., Serlie MJ; Department of Endocrinology and Metabolism (S.M.O., M.J.S.), Amsterdam University Medical Centers, Academic Medical Center, the Netherlands., Goldberg IJ; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, New York University Langone School of Medicine (I.J.G.)., Civelek M; Department of Biomedical Engineering, University of Virginia, Charlottesville (M.C.)., Parks BW; Department of Nutritional Sciences, University of Wisconsin-Madison (B.W.P)., Lusis AJ; Department of Medicine, Human Genetics, Microbiology, Immunology and Molecular Genetics, University of California Los Angeles (A.J.L.)., Knaack D; Department of Biochemistry (D.K., R.L.S., S.C.M., D.S.), Medical College of Wisconsin, Milwaukee., Schill RL; Department of Biochemistry (D.K., R.L.S., S.C.M., D.S.), Medical College of Wisconsin, Milwaukee.; Now with Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI (R.L.S.)., May SC; Department of Biochemistry (D.K., R.L.S., S.C.M., D.S.), Medical College of Wisconsin, Milwaukee., Reho JJ; Department of Physiology (J.J.R., J.L.G.), Medical College of Wisconsin, Milwaukee.; Comprehensive Rodent Metabolic Phenotyping Core, Department of Physiology, Medical College of Wisconsin, Milwaukee (J.J.R., J.L.G.)., Grobe JL; Cardiovascular Center (M.J.T., J.L.G., D.S., M.G.S.-T.), Medical College of Wisconsin, Milwaukee.; Department of Physiology (J.J.R., J.L.G.), Medical College of Wisconsin, Milwaukee.; Comprehensive Rodent Metabolic Phenotyping Core, Department of Physiology, Medical College of Wisconsin, Milwaukee (J.J.R., J.L.G.).; Department of Biomedical Engineering (J.L.G.)., Gantner B; Department of Medicine, Division of Endocrinology and Molecular Medicine (H.X., S.K., A.B.O., E.M., B.G., D.S., M.G.S.-T.), Medical College of Wisconsin, Milwaukee., Sahoo D; Department of Medicine, Division of Endocrinology and Molecular Medicine (H.X., S.K., A.B.O., E.M., B.G., D.S., M.G.S.-T.), Medical College of Wisconsin, Milwaukee.; Pharmacology & Toxicology (M.J.T., R.K., D.S., M.G.S.-T.), Medical College of Wisconsin, Milwaukee.; Cardiovascular Center (M.J.T., J.L.G., D.S., M.G.S.-T.), Medical College of Wisconsin, Milwaukee.; Department of Biochemistry (D.K., R.L.S., S.C.M., D.S.), Medical College of Wisconsin, Milwaukee., Sorci-Thomas MG; Department of Medicine, Division of Endocrinology and Molecular Medicine (H.X., S.K., A.B.O., E.M., B.G., D.S., M.G.S.-T.), Medical College of Wisconsin, Milwaukee.; Pharmacology & Toxicology (M.J.T., R.K., D.S., M.G.S.-T.), Medical College of Wisconsin, Milwaukee.; Cardiovascular Center (M.J.T., J.L.G., D.S., M.G.S.-T.), Medical College of Wisconsin, Milwaukee.

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Nov; Vol. 41 (11), pp. 2708-2725. Date of Electronic Publication: 2021 Sep 23.