Tau deposition patterns are associated with functional connectivity in primary tauopathies

Autor: Nicolai Franzmeier, Matthias Brendel, Leonie Beyer, Luna Slemann, Gabor G. Kovacs, Thomas Arzberger, Carolin Kurz, Gesine Respondek, Milica J. Lukic, Davina Biel, Anna Rubinski, Lukas Frontzkowski, Selina Hummel, Andre Müller, Anika Finze, Carla Palleis, Emanuel Joseph, Endy Weidinger, Sabrina Katzdobler, Mengmeng Song, Gloria Biechele, Maike Kern, Maximilian Scheifele, Boris-Stephan Rauchmann, Robert Perneczky, Michael Rullman, Marianne Patt, Andreas Schildan, Henryk Barthel, Osama Sabri, Jost J. Rumpf, Matthias L. Schroeter, Joseph Classen, Victor Villemagne, John Seibyl, Andrew W. Stephens, Edward B. Lee, David G. Coughlin, Armin Giese, Murray Grossman, Corey T. McMillan, Ellen Gelpi, Laura Molina-Porcel, Yaroslau Compta, John C. van Swieten, Laura Donker Laat, Claire Troakes, Safa Al-Sarraj, John L. Robinson, Sharon X. Xie, David J. Irwin, Sigrun Roeber, Jochen Herms, Mikael Simons, Peter Bartenstein, Virginia M. Lee, John Q. Trojanowski, Johannes Levin, Günter Höglinger, Michael Ewers

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Tau pathology drives neuronal dysfunction in 4- repeat tauopathies. Here, the authors combine tau-PET, resting-state fMRI and histopathology data, to show that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.

Externí odkaz: https://doaj.org/article/bd1a4c237aa0450eb6ad79b56669c4c6

Superiority of Formalin-Fixed Paraffin-Embedded Brain Tissue for in vitro Assessment of Progressive Supranuclear Palsy Tau Pathology With [18F]PI-2620

Autor: Marie Willroider, Sigrun Roeber, Anja K. E. Horn, Thomas Arzberger, Maximilian Scheifele, Gesine Respondek, Osama Sabri, Henryk Barthel, Marianne Patt, Olena Mishchenko, Andreas Schildan, André Mueller, Norman Koglin, Andrew Stephens, Johannes Levin, Günter U. Höglinger, Peter Bartenstein, Jochen Herms, Matthias Brendel, Leonie Beyer

Publikováno v: Frontiers in Neurology, Vol 12 (2021)

Objectives: Autoradiography on brain tissue is used to validate binding targets of newly discovered radiotracers. The purpose of this study was to correlate quantification of autoradiography signal using the novel next-generation tau positron emissio

Externí odkaz: https://doaj.org/article/204039db83664a75824cf7da9c040999

Superiority of Formalin-Fixed Paraffin-Embedded Brain Tissue for in vitro Assessment of Progressive Supranuclear Palsy Tau Pathology With [18F]PI-2620

Autor: Willroider, Marie, Roeber, Sigrun, Horn, Anja K. E., Arzberger, Thomas, Scheifele, Maximilian, Respondek, Gesine, Sabri, Osama, Barthel, Henryk, Patt, Marianne, Mishchenko, Olena, Schildan, Andreas, Mueller, André, Koglin, Norman, Stephens, Andrew, Levin, Johannes, Höglinger, Günther U., Bartenstein, Peter, Herms, Jochen, Brendel, Matthias, Beyer, Leonie

Objectives: Autoradiography on brain tissue is used to validate binding targets of newly discovered radiotracers. The purpose of this study was to correlate quantification of autoradiography signal using the novel next-generation tau positron emissio

Externí odkaz: https://ul.qucosa.de/id/qucosa%3A84337
https://ul.qucosa.de/api/qucosa%3A84337/attachment/ATT-0/

Evaluation of early-phase [18F]-florbetaben PET acquisition in clinical routine cases

Autor: Sonja Daerr, Matthias Brendel, Christian Zach, Erik Mille, Dorothee Schilling, Mathias Johannes Zacherl, Katharina Bürger, Adrian Danek, Oliver Pogarell, Andreas Schildan, Marianne Patt, Henryk Barthel, Osama Sabri, Peter Bartenstein, Axel Rominger

Publikováno v: NeuroImage: Clinical, Vol 14, Iss C, Pp 77-86 (2017)

Objectives: In recent years several [18F]-labelled amyloid PET tracers have been developed and have obtained clinical approval. There is accumulating evidence that early (post injection) acquisitions with these tracers are equally informative as conv

Externí odkaz: https://doaj.org/article/f8b638ef9d4741bea6b28682fcc5b68f

Additive value of [18F]PI-2620 perfusion imaging in progressive supranuclear palsy and corticobasal syndrome

Autor: Katzdobler, Sabrina, Nitschmann, Alexander, Nack, Anne, Fietzek, Urban, Kurz, Carolin, Häckert, Jan, Stapf, Theresa, Ferschmann, Christian, Scheifele, Heinrich Maximilian, Eckenweber, Florian, Biechele, Gloria, Franzmeier, Nicolai, Barthel, Henryk, Dewenter, Anna, Schönecker, Sonja, Saur, Dorothee, Schroeter, Matthias L, Rumpf, Jost-Julian, Rullmann, Michael, Schildan, Andreas, Patt, Marianne, Stephens, Andrew W, van Eimeren, Thilo, Bischof, Gerard, Neumaier, Bernd, Drzezga, Alexander, Danek, Adrian, Classen, Joseph, Bürger, Katharina, Janowitz, Daniel, Rauchmann, Boris Stephan, Stöcklein, Sophia, Perneczky, Robert, Schöberl, Florian, Beyer, Leonie, Zwergal, Andreas, Höglinger, Günter U, Bartenstein, Peter, Villemagne, Victor, Seibyl, John, Sabri, Osama, Levin, Johannes, Brendel, Matthias, Tauopathies, German Imaging Initiative for, Marek, Ken, Song, Mengmeng, Wagemann, Olivia, Palleis, Carla, Weidinger, Endy

Publikováno v: European journal of nuclear medicine and molecular imaging 50(2), 423-434 (2023). doi:10.1007/s00259-022-05964-w
European Journal of Nuclear Medicine and Molecular Imaging

Purpose Early after [18F]PI-2620 PET tracer administration, perfusion imaging has potential for regional assessment of neuronal injury in neurodegenerative diseases. This is while standard late-phase [18F]PI-2620 tau-PET is able to discriminate the 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444aaa06df012997249a3b4b760f94a4
https://pub.dzne.de/record/165243