Identification of BIRC6 as a novel intervention target for neuroblastoma therapy

Autor: Lamers Fieke, Schild Linda, Koster Jan, Speleman Frank, Øra Ingrid, Westerhout Ellen M, van Sluis Peter, Versteeg Rogier, Caron Huib N, Molenaar Jan J

Publikováno v: BMC Cancer, Vol 12, Iss 1, p 285 (2012)

Abstract Background Neuroblastoma are pediatric tumors of the sympathetic nervous system with a poor prognosis. Apoptosis is often deregulated in cancer cells, but only a few defects in apoptotic routes have been identified in neuroblastoma. Methods

Externí odkaz: https://doaj.org/article/1b80ed0521124447bce0b293ce5b4679

Implementation of paediatric precision oncology into clinical practice: The Individualized Therapies for Children with cancer program ‘iTHER’

Autor: Langenberg, Karin P.S., Meister, Michael T., Bakhuizen, Jette J., Boer, Judith M., van Eijkelenburg, Natasha K.A., Hulleman, Esther, Ilan, Uri, Looze, Eleonora J., Dierselhuis, Miranda P., van der Lugt, Jasper, Breunis, Willemijn, Schild, Linda G., Ober, Kimberley, van Hooff, Sander R., Scheijde-Vermeulen, Marijn A., Hiemcke-Jiwa, Laura S., Flucke, Uta E., Kranendonk, Mariette E.G., Wesseling, Pieter, Sonneveld, Edwin, Punt, Simone, Boltjes, Arjan, van Dijk, Freerk, Verwiel, Eugene T.P., Volckmann, Richard, Hehir-Kwa, Jayne Y., Kester, Lennart A., Koudijs, Marco M.J., Waanders, Esme, Holstege, Frank C.P., Vormoor, H. Josef, Hoving, Eelco W., van Noesel, Max M., Pieters, Rob, Kool, Marcel, Stumpf, Miriam, Blattner-Johnson, Mirjam, Balasubramanian, Gnana P., Van Tilburg, Cornelis M., Jones, Barbara C., Jones, David T.W., Witt, Olaf, Pfister, Stefan M., Jongmans, Marjolijn C.J., Kuiper, Roland P., de Krijger, Ronald R., Wijnen, Marc H.W., den Boer, Monique L., Zwaan, C. Michel, Kemmeren, Patrick, Koster, Jan, Tops, Bastiaan B.J., Goemans, Bianca F., Molenaar, Jan J.

Publikováno v: In European Journal of Cancer November 2022 175:311-325

Combined targeting of the p53 and pRb pathway in neuroblastoma does not lead to synergistic responses

Autor: Schubert, Nil A., Schild, Linda, van Oirschot, Stijn, Keller, Kaylee M., Alles, Lindy K., Vernooij, Lindy, Nulle, Marloes E., Dolman, M. Emmy M., van den Boogaard, Marlinde L., Molenaar, Jan J.

Publikováno v: In European Journal of Cancer January 2021 142:1-9

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Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma

Autor: Keller, Kaylee M., Eleveld, Thomas F., Schild, Linda, van den Handel, Kim, van den Boogaard, Marlinde, Amo-Addae, Vicky, Eising, Selma, Ober, Kimberley, Koopmans, Bianca, Looijenga, Leendert, Tytgat, Godelieve A.M., Ylstra, Bauke, Molenaar, Jan J., Dolman, M. Emmy M., van Hooff, Sander R., Afd Pharmaceutics, Pharmaceutics

Publikováno v: Frontiers in Oncology, 12, 1. Frontiers Media S.A.
Frontiers in Oncology, 12:929123. Frontiers Media S.A.
Frontiers in oncology, 12:929123. Frontiers Media S.A.
Keller, K M, Eleveld, T F, Schild, L, van den Handel, K, van den Boogaard, M, Amo-Addae, V, Eising, S, Ober, K, Koopmans, B, Looijenga, L, Tytgat, G A M, Ylstra, B, Molenaar, J J, Dolman, M E M & van Hooff, S R 2022, ' Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma ', Frontiers in Oncology, vol. 12, 929123 . https://doi.org/10.3389/fonc.2022.929123

Neuroblastoma is the most common extracranial solid tumor found in children and despite intense multi-modal therapeutic approaches, low overall survival rates of high-risk patients persist. Tumors with heterozygous loss of chromosome 11q and MYCN amp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329aea7d7c7654768bccaddc20ad5c25
https://dspace.library.uu.nl/handle/1874/425877