Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo.

Autor: Bertheloot D; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Wanderley CW; Center for Research in Inflammatory Diseases (CRID), Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil., Schneider AH; Center for Research in Inflammatory Diseases (CRID), Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil., Schiffelers LD; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Wuerth JD; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Tödtmann JM; Core Facility Nanobodies, Medical Faculty, University of Bonn, Bonn, Germany., Maasewerd S; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Hawwari I; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Duthie F; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Rohland C; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Ribeiro LS; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Jenster LM; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Rosero N; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Tesfamariam YM; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Cunha FQ; Center for Research in Inflammatory Diseases (CRID), Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil., Schmidt FI; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.; Core Facility Nanobodies, Medical Faculty, University of Bonn, Bonn, Germany., Franklin BS; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2022 Jun 08; Vol. 14 (6), pp. e15415. Date of Electronic Publication: 2022 Apr 19.