Normal B cells express ZAP70 in chronic lymphocytic leukemia: A link between autoimmunity and lymphoproliferation?

Autor: Ghergus D; Strasbourg University, Strasbourg, France.; Department of Clinical Hematology, Hospices Civils de Lyon, Lyon, France., Martin M; Strasbourg University, Strasbourg, France.; Department of Clinical Immunology and Internal Medicine, Tertiary Center for Primary Immunodeficiency, National Reference Center for Systemic Autoimmune Diseases (CNR RESO), Strasbourg University Hospital, Strasbourg, France.; Department of Internal Medicine, Poitiers University Hospital, Poitiers, France., Knapp AM; Strasbourg University, Strasbourg, France., Delmotte F; Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA., Joublin-Delavat A; Strasbourg University, Strasbourg, France., Jung S; Strasbourg University, Strasbourg, France.; Faculty of Dentistry, Strasbourg University, Strasbourg, France., Schickel JN; Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA., Mendel I; French Blood Institute of Strasbourg, Strasbourg, France., Dupuis A; French Blood Institute of Strasbourg, Strasbourg, France., Drénou B; Department of Hematology, Groupe Hospitalier de la Région Mulhouse Sud Alsace, Mulhouse, France., Ghesquières H; Department of Clinical Hematology, Hospices Civils de Lyon, Lyon, France., Salles G; Department of Clinical Hematology, Hospices Civils de Lyon, Lyon, France., Baseggio L; Laboratory of Hematology, Hospices Civils de Lyon, Lyon, France., Herbrecht R; Department of Hematology, Institut de Cancérologie Strasbourg Europe (ICANS), Strasbourg, France.; Strasbourg University, IINSERM UMR-S1113/IRFAC, Strasbourg, France., Korganow AS; Strasbourg University, Strasbourg, France.; Department of Clinical Immunology and Internal Medicine, Tertiary Center for Primary Immunodeficiency, National Reference Center for Systemic Autoimmune Diseases (CNR RESO), Strasbourg University Hospital, Strasbourg, France., Vallat L; Department of Molecular Genetics of Cancer, Strasbourg University Hospital and INSERM UMR-S1113, Strasbourg, France., Soulas-Sprauel P; Strasbourg University, Strasbourg, France.; Faculty of Pharmacy, Strasbourg University, Strasbourg, France., Meffre E; Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA., Martin T; Strasbourg University, Strasbourg, France.; Department of Clinical Immunology and Internal Medicine, Tertiary Center for Primary Immunodeficiency, National Reference Center for Systemic Autoimmune Diseases (CNR RESO), Strasbourg University Hospital, Strasbourg, France.

Publikováno v: American journal of hematology [Am J Hematol] 2024 Jan; Vol. 99 (1), pp. 48-56. Date of Electronic Publication: 2023 Oct 19.

Positive and negative selection shape the human naive B cell repertoire.

Autor: Chen JW; Department of Immunobiology, Yale University, New Haven, Connecticut, USA., Schickel JN; Department of Immunobiology, Yale University, New Haven, Connecticut, USA., Tsakiris N; Department of Immunobiology, Yale University, New Haven, Connecticut, USA., Sng J; Department of Immunobiology, Yale University, New Haven, Connecticut, USA., Arbogast F; Department of Immunobiology, Yale University, New Haven, Connecticut, USA., Bouis D; Department of Immunobiology, Yale University, New Haven, Connecticut, USA., Parisi D; Department of Immunobiology, Yale University, New Haven, Connecticut, USA., Gera R; Department of Immunobiology, Yale University, New Haven, Connecticut, USA., Boeckers JM; Department of Immunobiology, Yale University, New Haven, Connecticut, USA., Delmotte FR; Department of Immunobiology, Yale University, New Haven, Connecticut, USA., Veselits M; Department of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Illinois, USA., Schuetz C; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.; Department of Pediatrics, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Jacobsen EM; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany., Posovszky C; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany., Schulz AS; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany., Schwarz K; Institute for Transfusion Medicine, University of Ulm, Ulm, Germany.; Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service Baden-Württemberg, Hessen, Ulm, Germany., Clark MR; Department of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Illinois, USA., Menard L; Department of Immunobiology, Yale University, New Haven, Connecticut, USA., Meffre E; Department of Immunobiology, Yale University, New Haven, Connecticut, USA.; Section of Rheumatology, Allergy and Clinical Immunology, Yale School of Medicine, New Haven, Connecticut, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2022 Jan 18; Vol. 132 (2).

Publisher Correction: Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis.

Autor: Serwas NK; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Department of Pathology, University of California San Francisco, San Francisco, CA, USA., Hoeger B; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Ardy RC; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Stulz SV; Centre for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden., Sui Z; Division of Cell Biology, La Jolla Institute for Allergy & Immunology, La Jolla, CA, 92037, USA., Memaran N; Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.; Centre for Paediatrics and Adoloscent Medicine, Hannover Medical School, Hannover, Germany., Meeths M; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.; Clinical Genetics Unit, Department of Molecular Medicine and Surgery, and Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden., Krolo A; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Petronczki ÖY; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Pfajfer L; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Center for Pathophysiology of Toulouse Purpan, INSERM UMR1043, CNRS UMR5282, Paul Sabatier University, Toulouse, France., Hou TZ; Institute of Immunity and Transplantation, Division of Infection & Immunity, School of Life and Medical Sciences, University College London, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK., Halliday N; Institute of Immunity and Transplantation, Division of Infection & Immunity, School of Life and Medical Sciences, University College London, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK., Santos-Valente E; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Kalinichenko A; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Kennedy A; Institute of Immunity and Transplantation, Division of Infection & Immunity, School of Life and Medical Sciences, University College London, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK., Mace EM; Department of Pediatrics, Baylor College of Medicine and Center for Human Immunobiology, Texas Children's Hospital, Houston, TX, 77030, USA.; Columbia University Medical Center, Columbia, NY, USA., Mukherjee M; Department of Pediatrics, Baylor College of Medicine and Center for Human Immunobiology, Texas Children's Hospital, Houston, TX, 77030, USA., Tesi B; Clinical Genetics Unit, Department of Molecular Medicine and Surgery, and Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden., Schrempf A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Pickl WF; Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Loizou JI; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Kain R; Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria., Bidmon-Fliegenschnee B; Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria., Schickel JN; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 06511, USA., Glauzy S; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 06511, USA., Huemer J; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Garncarz W; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Salzer E; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Pierides I; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Bilic I; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Takeda (Shire), Vienna, Austria., Thiel J; Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, 79106, Germany., Priftakis P; Astrid Lindgren Children's Hospital, Karolinska University Hospital Huddinge, Stockholm, Sweden., Banerjee PP; Department of Pediatrics, Baylor College of Medicine and Center for Human Immunobiology, Texas Children's Hospital, Houston, TX, 77030, USA.; MD Anderson Cancer Center, Houston, TX, USA., Förster-Waldl E; Department of Pediatrics and Adolescent Medicine, Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Medical University of Vienna, Vienna, Austria., Medgyesi D; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Huber WD; Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria., Orange JS; Department of Pediatrics, Baylor College of Medicine and Center for Human Immunobiology, Texas Children's Hospital, Houston, TX, 77030, USA.; Columbia University Medical Center, Columbia, NY, USA., Meffre E; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 06511, USA., Sansom DM; Institute of Immunity and Transplantation, Division of Infection & Immunity, School of Life and Medical Sciences, University College London, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK., Bryceson YT; Centre for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden., Altman A; Division of Cell Biology, La Jolla Institute for Allergy & Immunology, La Jolla, CA, 92037, USA., Boztug K; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria. kaan.boztug@ccri.at.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. kaan.boztug@ccri.at.; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria. kaan.boztug@ccri.at.; Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. kaan.boztug@ccri.at.; St. Anna Kinderspital, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. kaan.boztug@ccri.at.

Publikováno v: Nature communications [Nat Commun] 2019 Oct 02; Vol. 10 (1), pp. 4555. Date of Electronic Publication: 2019 Oct 02.

AIRE expression controls the peripheral selection of autoreactive B cells.

Autor: Sng J; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA., Ayoglu B; School of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA., Chen JW; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA., Schickel JN; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA., Ferre EMN; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD USA., Glauzy S; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA., Romberg N; Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hoenig M; Department of Pediatrics, University Medical Centre Ulm, Ulm, Germany., Cunningham-Rundles C; Division of Allergy and Immunology, Department of Medicine, Icahn School of Medicine, Mount Sinai, New York, NY 10029, USA., Utz PJ; School of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.; Institute for Immunity, Transplantation, and Infection (ITI), Stanford University, Stanford, CA 94305, USA., Lionakis MS; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD USA., Meffre E; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA. eric.meffre@yale.edu.

Publikováno v: Science immunology [Sci Immunol] 2019 Apr 12; Vol. 4 (34).

Reprogramming human T cell function and specificity with non-viral genome targeting.

Autor: Roth TL; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Puig-Saus C; Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA., Yu R; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Shifrut E; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Carnevale J; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Li PJ; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Hiatt J; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Saco J; Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA., Krystofinski P; Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA., Li H; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA., Tobin V; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Nguyen DN; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Lee MR; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA., Putnam AL; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA., Ferris AL; HIV Dynamics and Replication Program, Vector Design and Replication Section, National Cancer Institute, Frederick, MD, USA., Chen JW; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Schickel JN; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Pellerin L; Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA., Carmody D; Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, Departments of Medicine and Pediatrics, The University of Chicago, Chicago, IL, USA., Alkorta-Aranburu G; Department of Human Genetics, The University of Chicago, Chicago, IL, USA., Del Gaudio D; Department of Human Genetics, The University of Chicago, Chicago, IL, USA., Matsumoto H; Takara Bio USA, Inc, Mountain View, CA, USA., Morell M; Takara Bio USA, Inc, Mountain View, CA, USA., Mao Y; Takara Bio USA, Inc, Mountain View, CA, USA., Cho M; Chan Zuckerberg Biohub, San Francisco, CA, USA., Quadros RM; Mouse Genome Engineering Core Facility, Vice Chancellor for Research Office, University of Nebraska Medical Center, Omaha, NE, USA., Gurumurthy CB; Mouse Genome Engineering Core Facility, Vice Chancellor for Research Office, University of Nebraska Medical Center, Omaha, NE, USA., Smith B; Takara Bio USA, Inc, Mountain View, CA, USA., Haugwitz M; Takara Bio USA, Inc, Mountain View, CA, USA., Hughes SH; HIV Dynamics and Replication Program, Vector Design and Replication Section, National Cancer Institute, Frederick, MD, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Weissman JS; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA., Schumann K; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Esensten JH; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA., May AP; Chan Zuckerberg Biohub, San Francisco, CA, USA., Ashworth A; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Kupfer GM; Department of Pediatrics, Pathology, Yale School of Medicine, New Haven, CT, USA., Greeley SAW; Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, Departments of Medicine and Pediatrics, The University of Chicago, Chicago, IL, USA., Bacchetta R; Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA., Meffre E; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Roncarolo MG; Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA., Romberg N; Division of Immunology and Allergy, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Herold KC; Departments of Immunobiology and Internal Medicine, Yale University, New Haven, CT, USA., Ribas A; Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.; Department of Surgery, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Medical and Molecular Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA., Leonetti MD; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Marson A; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA. alexander.marson@ucsf.edu.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA. alexander.marson@ucsf.edu.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. alexander.marson@ucsf.edu.; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA. alexander.marson@ucsf.edu.; Chan Zuckerberg Biohub, San Francisco, CA, USA. alexander.marson@ucsf.edu.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. alexander.marson@ucsf.edu.

Publikováno v: Nature [Nature] 2018 Jul; Vol. 559 (7714), pp. 405-409. Date of Electronic Publication: 2018 Jul 11.