Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.

Autor: Huang LO; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Gentofte, Denmark., Rauch A; Functional Genomics & Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Molecular Endocrinology & Stem Cell Research Unit, Department of Endocrinology and Metabolism, Odense University Hospital and Steno Diabetes Center Odense and Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Mazzaferro E; The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden., Preuss M; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA., Carobbio S; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Bayrak CS; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA., Chami N; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA., Wang Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA., Schick UM; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA., Yang N; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA., Itan Y; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA., Vidal-Puig A; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.; University of Cambridge Metabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK., den Hoed M; The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden., Mandrup S; Functional Genomics & Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA. ruth.loos@mssm.edu.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA. ruth.loos@mssm.edu.; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA. ruth.loos@mssm.edu.

Publikováno v: Nature metabolism [Nat Metab] 2021 Feb; Vol. 3 (2), pp. 228-243. Date of Electronic Publication: 2021 Feb 22.

Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair EDITORIAL COMMENT

Autor: Day, FR, Ruth, KS, Thompson, DJ, Lunetta, KL, Pervjakova, N, Chasman, DI, Stolk, Lisette, Finucane, HK, Sulem, P, Bulik-Sullivan, B, Esko, T, Johnson, AD, Elks, CE, Franceschini, N, He, C, Altmaier, E, Brody, JA, Franke, LL, Huffman, JE, Keller, MF, McArdle, PF, Nutile, T, Porcu, E, Robino, A, Rose, LM, Schick, UM, Smith, JA, Teumer, A, Traglia, M, Vuckovic, D, Yao, J, Zhao, W, Albrecht, E, Amin, Najaf, Corre, T, Hottenga, JJ (Jouke Jan), Mangino, M, Smith, AV, Tanaka, T, Abecasis, GR, Andrulis, IL, Anton-Culver, H, Antoniou, AC, Arndt, V, Arnold, AM, Barbieri, C, Beckmann, MW, Beeghly-Fadiel, A, Benitez, J, Bernstein, L, Bielinski, SJ, Blomqvist, C, Boerwinkle, E, Bogdanova, NV, Bojesen, SE, Bolla, MK, Borresen-Dale, AL, Boutin, TS, Brauch, H, Brenner, H, Bruning, T, Burwinkel, B, Campbell, A (Archie), Campbell, H, Chanock, SJ, Chapman, JR, Chen, YDI, Chenevix-Trench, G, Couch, FJ, Coviello, AD, Cox, A, Czene, K, Darabi, H, de Vivo, I, Demerath, EW, Dennis, J, Devilee, P, Dork, T, dos-Santos-Silva, I, Dunning, AM, Eicher, JD, Fasching, PA, Faul, JD, Figueroa, J, Flesch-Janys, D, Gandin, I, Garcia, ME, Garcia-Closas, M, Giles, GG, Girotto, GG, Goldberg, MS, Gonzalez-Neira, A, Goodarzi, MO, Grove, ML, Gudbjartsson, DF, Guenel, P, Guo, XQ, Haiman, CA, Hall, P, Hamann, U, Henderson, BE, Hocking, LJ, Hofman, Bert, Homuth, G, Hooning, Maartje, Hopper, JL, Hu, FB, Huang, JY, Humphreys, K, Hunter, DJ, Jakubowska, A, Jones, SE, Kabisch, M, Karasik, D, Knight, JA, Kolcic, I, Kooperberg, C, Kosma, VM, Kriebel, J, Kristensen, V, Lambrechts, D, Langenberg, C, Li, JM, Li, X, Lindstrom, S, Liu, YM, Luan, JA, Lubinski, J, Magi, R, Mannermaa, A, Manz, J, Margolin, S, Marten, J, Martin, NG, Masciullo, C, Meindl, A, Michailidou, K, Mihailov, E, Milani, L, Milne, RL, Muller-Nurasyid, M, Nalls, M, Neale, BM, Nevanlinna, H, Neven, P, Newman, AB, Nordestgaard, BG, Olson, JE, Padmanabhan, S, Peterlongo, P, Peters, U, Petersmann, A, Peto, J, Pharoah, PDP, Pirastu, NN, Pirie, A, Pistis, G, Polasek, O, Porteous, D, Psaty, BM, Pylkas, K, Radice, P, Raffel, LJ, Rivadeneira, Fernando, Rudan, I, Rudolph, A, Ruggiero, D, Sala, CF, Sanna, S, Sawyer, EJ, Schlessinger, D, Schmidt, MK (Marjanka), Schmidt, F, Schmutzler, RK, Schoemaker, MJ, Scott, RA, Seynaeve, Caroline, Simard, J, Sorice, R, Southey, MC, Stockl, D, Strauch, K, Swerdlow, A, Taylor, KD, Thorsteinsdottir, U, Toland, AE, Tomlinson, I, Truong, T, Tryggvadottir, L, Turner, ST, Vozzi, D, Wang, Q (Qing), Wellons, M, Willemsen, G, Wilson, JF, Winqvist, R, Wolffenbuttel, BBHR, Wright, AF, Yannoukakos, D, Zemunik, T, Zheng, W, Zygmunt, M, Bergmann, S, Boomsma, DI, Buring, JE, Ferrucci, L, Montgomery, GW, Gudnason, V, Spector, TD, Duijn, Cornelia, Alizadeh, BZ, Ciullo, M, Crisponi, L, Easton, DF, Gasparini, PP, Gieger, C, Harris, TB, Hayward, C, Kardia, SLR, Kraft, P, McKnight, B, Metspalu, A, Morrison, AC, Reiner, AP, Ridker, PM, Rotter, JI, Toniolo, D, Uitterlinden, André, Ulivi, S, Volzke, H, Wareham, NJ, Weir, DR, Yerges-Armstrong, LM, Price, AL, Stefansson, K, Visser, Jenny, Ong, KK, Chang-Claude, J, Murabito, JM, Perry, JRB, Murray, A

Publikováno v: Obstetrical and Gynecological Survey, 70(12), 758-762. Lippincott Williams and Wilkins
Day, F R, Ruth, K S, Thompson, D J, Lunetta, K L, Pervjakova, N, Chasman, D I, Stolk, L, Finucane, H K, Sulem, P, Bulik-Sullivan, B, Esko, T, Johnson, A D, Elks, C E, Franceschini, N, He, C, Altmaier, E, Brody, J A, Franke, L L, Huffman, J E, Keller, M F, McArdle, P F, Nutile, T, Porcu, E, Robino, A, Rose, L M, Schick, U M, Smith, J A, Teumer, A, Traglia, M, Vuckovic, D, Yao, J, Zhao, W, Albrecht, E, Amin, N, Corre, T, Hottenga, J, Mangino, M, Smith, A V, Tanaka, T, Abecasis, G R, Andrulis, I L, Anton-Culver, H, Antoniou, A C, Arndt, V, Arnold, A M, Barbieri, C, Beckmann, M W, Beeghly-Fadiel, A, Benitez, J, Bernstein, L, Bielinski, S J, Blomqvist, C, Boerwinkle, E, Bogdanova, N V, Bojesen, S E, Bolla, M K, Borresen-Dale, A, Boutin, T S, Brauch, H, Brenner, H, Bruening, T, Burwinkel, B, Campbell, A, Campbell, H, Chanock, S J, Chapman, J R, Chen, Y I, Chenevix-Trench, G, Couch, F J, Coviello, A D, Cox, A, Czene, K, Darabi, H, De Vivo, I, Demerath, E W, Dennis, J, Devilee, P, Doerk, T, dos-Santos-Silva, I, Dunning, A M, Eicher, J D, Fasching, P A, Faul, J D, Figueroa, J, Flesch-Janys, D, Gandin, I, Garcia, M E, Garcia-Closas, M, Giles, G G, Girotto, G G, Goldberg, M S, Gonzalez-Neira, A, Goodarzi, M O, Grove, M L, Gudbjartsson, D F, Guenel, P, Guo, X, Haiman, C A, Hall, P, Hamann, U, Henderson, B E, Hocking, L J, Hofman, A, Homuth, G, Hooning, M J, Hopper, J L, Hu, F B, Huang, J, Humphreys, K, Hunter, D J, Jakubowska, A, Jones, S E, Kabisch, M, Karasik, D, Knight, J A, Kolcic, I, Kooperberg, C, Kosma, V, Kriebel, J, Kristensen, V, Lambrechts, D, Langenberg, C, Li, J, Li, X, Lindstroem, S, Liu, Y, Luan, J, Lubinski, J, Maegi, R, Mannermaa, A, Manz, J, Margolin, S, Marten, J, Martin, N G, Masciullo, C, Meindl, A, Michailidou, K, Mihailov, E, Milani, L, Milne, R L, Mueller-Nurasyid, M, Nalls, M, Neale, B M, Nevanlinna, H, Neven, P, Newman, A B, Nordestgaard, B G, Olson, J E, Padmanabhan, S, Peterlongo, P, Peters, U, Petersmann, A, Peto, J, Pharoah, P D P, Pirastu, N N, Pirie, A, Pistis, G, Polasek, O, Porteous, D, Psaty, B M, Pylkaes, K, Radice, P, Raffel, L J, Rivadeneira, F, Rudan, I, Rudolph, A, Ruggiero, D, Sala, C F, Sanna, S, Sawyer, E J, Schlessinger, D, Schmidt, M K, Schmidt, F, Schmutzler, R K, Schoemaker, M J, Scott, R A, Seynaeve, C M, Simard, J, Sorice, R, Southey, M C, Stoeckl, D, Strauch, K, Swerdlow, A, Taylor, K D, Thorsteinsdottir, U, Toland, A E, Tomlinson, I, Truong, T, Tryggvadottir, L, Turner, S T, Vozzi, D, Wang, Q, Wellons, M, Willemsen, G, Wilson, J F, Winqvist, R, Wolffenbuttel, B B H R, Wright, A F, Yannoukakos, D, Zemunik, T, Zheng, W, Zygmunt, M, Bergmann, S, Boomsma, D I, Buring, J E, Ferrucci, L, Montgomery, G W, Gudnason, V, Spector, T D, van Duijn, C M, Alizadeh, BZ, Ciullo, M, Crisponi, L, Easton, D F, Gasparini, P P, Gieger, C, Harris, T B, Hayward, C, Kardia, S L R, Kraft, P, McKnight, B, Metspalu, A, Morrison, A C, Reiner, A P, Ridker, P M, Rotter, J I, Toniolo, D, Uitterlinden, A G, Ulivi, S, Voelzke, H, Wareham, N J, Weir, D R, Yerges-Armstrong, L M, Price, A L, Stefansson, K, Visser, J A, Ong, K K, Chang-Claude, J, Murabito, J M, Perry, J R B & Murray, A 2015, ' Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair EDITORIAL COMMENT ', Obstetrical and Gynecological Survey, vol. 70, no. 12, pp. 758-762 . https://doi.org/10.1097/01.ogx.0000473766.71624.99
Obstetrical and Gynecological Survey, 70(12), 758-762. Lippincott Williams & Wilkins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::aee02ec386b900e68322f081c3e42e1a
https://research.vu.nl/en/publications/2398f5ac-481a-458c-bb9b-29df62fa401b

Generalization and fine mapping of red blood cell trait genetic associations to multi-ethnic populations: The PAGE Study.

Autor: Jo Hodonsky C; Department of Epidemiology, University of North Carolina Gillings School of Public Health, Chapel Hill, NC., Schurmann C; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, NY., Schick UM; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, NY.; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA., Kocarnik J; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA., Tao R; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN., van Rooij FJ; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3000, the Netherlands., Wassel C; Department of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, VT., Buyske S; Department of Statistics and Biostatistics, Hill Center, Rutgers, The State University of New Jersey, 110 Frelinghuysen Rd. Piscataway, NY., Fornage M; Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX., Hindorff LA; Division of Genomic Medicine, National Human Genome Research Institute, National institutes of Health, Bethesda, MD., Floyd JS; Departments of Medicine, University of Washington, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA., Ganesh SK; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI.; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI., Lin DY; Department of Biostatistics, University of North Carolina, Chapel Hill, NC., North KE; Department of Epidemiology, University of North Carolina Gillings School of Public Health, Chapel Hill, NC., Reiner AP; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA., Loos RJ; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, NY., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA., Avery CL; Department of Epidemiology, University of North Carolina Gillings School of Public Health, Chapel Hill, NC.; Carolina Population Center, University of North Carolina, Chapel Hill, NC.

Publikováno v: American journal of hematology [Am J Hematol] 2018 Jun 15. Date of Electronic Publication: 2018 Jun 15.

Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos.

Autor: Hodonsky CJ; Department of Epidemiology, University of North Carolina Gillings School of Public Health, Chapel Hill, NC, United States of America., Jain D; Department of Biostatistics, University of Washington, Seattle, WA, United States of America., Schick UM; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America., Morrison JV; Department of Biostatistics, University of Washington, Seattle, WA, United States of America., Brown L; Department of Biostatistics, University of Washington, Seattle, WA, United States of America., McHugh CP; Department of Biostatistics, University of Washington, Seattle, WA, United States of America.; New York Genome Center, New York, NY, United States of America., Schurmann C; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Chen DD; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, United States of America., Liu YM; School of Medicine, Wake Forest University, Winston-Salem, NC, United States of America., Auer PL; Joseph J. Zilber School of Public Health, University of Wisconsin Milwaukee, Milwaukee, WI, United States of America., Laurie CA; Department of Biostatistics, University of Washington, Seattle, WA, United States of America., Taylor KD; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA United States of America.; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA United States of America., Browning BL; Department of Medicine, University of Washington, Seattle, WA United States of America., Li Y; Department of Genetics, University of North Carolina, Chapel Hill, NC, United States of America.; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, United States of America.; Department of Computer Science, University of North Carolina, Chapel Hill, NC, United States of America., Papanicolaou G; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD, United States of America., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA United States of America.; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA United States of America., Kurita R; Research and Development Department, Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan., Nakamura Y; Cell Engineering Division, RIKEN BioResource Center, Tsukuba, Ibaraki, Japan.; Comprehensive Human Sciences, Tsukuba University, Tsukuba, Ibaraki, Japan., Browning SR; Department of Biostatistics, University of Washington, Seattle, WA, United States of America., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., North KE; Department of Epidemiology, University of North Carolina Gillings School of Public Health, Chapel Hill, NC, United States of America.; Department of Genetics, University of North Carolina, Chapel Hill, NC, United States of America., Laurie CC; Department of Biostatistics, University of Washington, Seattle, WA, United States of America., Thornton TA; Department of Biostatistics, University of Washington, Seattle, WA, United States of America., Pankratz N; Division of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN, United States of America., Bauer DE; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, United States of America.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, United States of America.; Department of Pediatrics, Harvard Medical School and Harvard Stem Cell Institute, Harvard University, Boston, MA, United States of America., Sofer T; Department of Biostatistics, University of Washington, Seattle, WA, United States of America., Reiner AP; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.

Publikováno v: PLoS genetics [PLoS Genet] 2017 Apr 28; Vol. 13 (4), pp. e1006760. Date of Electronic Publication: 2017 Apr 28 (Print Publication: 2017).

SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function.

Autor: Li M; Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland.; Division of Nephrology and Department of Human Genetics, University of Utah, Salt Lake City, Utah., Li Y; Division of Genetic Epidemiology, Medical Center - University of Freiburg, Freiburg, Germany., Weeks O; Genetics Division., Mijatovic V; Department of Life and Reproduction Sciences, and., Teumer A; Institute for Community Medicine., Huffman JE; National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts.; Center for Genomic & Experimental Medicine, Institute of Genetics and Molecular Medicine., Tromp G; The Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, Pennsylvania.; Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa., Fuchsberger C; Center for Biomedicine, European Academy of Bolzano/Bozen, affiliated to the University of Lübeck, Bolzano/Bozen, Italy.; Department of Biostatistics, Center for Statistical Genetics., Gorski M; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland., Nutile T; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso', Napoli, Italy., Sedaghat S; Department of Epidemiology, and., Sorice R; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso', Napoli, Italy., Tin A; Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland., Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts., Ahluwalia TS; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, and.; Steno Diabetes Center, Gentofte, Denmark., Arking DE; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Bihlmeyer NA; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Böger CA; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Carroll RJ; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee., Chasman DI; Genetics Division.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts., Cornelis MC; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Dehghan A; Department of Epidemiology, and., Faul JD; Survey Research Center, Institute for Social Research, and., Feitosa MF; Department of Genetics, School of Medicine, Washington University School of Medicine, St. Louis, Missouri., Gambaro G; Division of Nephrology, Gemelli Foundation University Hospital, Catholic University, Rome, Italy., Gasparini P; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', University of Trieste, Trieste, Italy., Giulianini F; Division of Preventive Medicine., Heid I; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.; Institute of Genetic Epidemiology and., Huang J; Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; State Key Laboratory of Medical Genomics, Shanghai, China., Imboden M; Swiss Tropical and Public Health Institute, Basel, Switzerland., Jackson AU; Department of Biostatistics, Center for Statistical Genetics., Jeff J; The Charles Bronfman Institute for Personalized Medicine, and., Jhun MA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan., Katz R; Kidney Research Institute., Kifley A; Center for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Westmead, Sydney, New South Wales, Australia., Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, and., Kumar A; Swiss Tropical and Public Health Institute, Basel, Switzerland., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Li-Gao R; Department of Epidemiology, and., Lohman K; Division of Public Health Sciences, Biostatistical Sciences, and., Lu Y; The Charles Bronfman Institute for Personalized Medicine, and., Mägi R; Estonian Genome Center of University of Tartu, Tartu, Estonia., Malerba G; Section of Biology and Genetics, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy., Mihailov E; Estonian Genome Center of University of Tartu, Tartu, Estonia., Mohlke KL; Department of Genetics, and., Mook-Kanamori DO; Department of Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Epidemiology Section, Department of Biostatistics Epidemiology & Scientific Computing, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Robino A; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy., Ruderfer D; Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York., Salvi E; Department of Health Science, University of Milano, Milano, Italy., Schick UM; Fred Hutchinson Cancer Research Center, Seattle, Washington., Schulz CA; Department of Clinical Science, Lund University, Malmö, Sweden., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan., Traglia M; San Raffaele Scientific Institute, Milano, Italy., Yerges-Armstrong LM; Program in Personalized and Genomic Medicine and Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan., Goodarzi MO; Department of Medicine and Department of Biomedical Sciences, and.; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California., Kraja AT; Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University, St. Louis, Missouri., Liu C; National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts., Wessel J; Department of Epidemiology, Fairbanks School of Public Health, Indianapolis, Indiana.; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Boerwinkle E; The Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas., Borecki IB; Department of Genetics, School of Medicine, Washington University School of Medicine, St. Louis, Missouri., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, and., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, and., Braga D; Department of Health Science, University of Milano, Milano, Italy., Brandslund I; Department of Clinical Biochemistry, and., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, and., Campbell A; Center for Genomic & Experimental Medicine, Institute of Genetics and Molecular Medicine., Carey DJ; The Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, Pennsylvania., Christensen C; Department of Internal Medicine and Endocrinology, Vejle Hospital, Vejle, Denmark., Coresh J; Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland., Crook E; Department of Medicine, University of South Alabama College of Medicine, Mobile, Alabama., Curhan GC; Renal Division and Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts., Cusi D; Department of Health Science, University of Milano, Milano, Italy.; Division of Nephrology, San Paolo Hospital, Milan, Italy., de Boer IH; Kidney Research Institute., de Vries AP; Division of Nephrology, Department of Medicine, Leiden University Medical Center and Leiden University, The Netherlands., Denny JC; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee., Devuyst O; University of Zurich, Institute of Physiology, Zurich Center for Integrative Human Physiology, Mechanisms of Inherited Kidney Disorders Group, Zürich, Switzerland., Dreisbach AW; Department of Medicine, University of Mississippi, Jackson, Mississippi., Endlich K; Department of Anatomy and Cell Biology., Esko T; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Estonian Genome Center of University of Tartu, Tartu, Estonia.; Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts.; Department of Genetics, Harvard Medical School, Boston, Massachusetts., Franco OH; Department of Epidemiology, and., Fulop T; Department of Medicine, University of Mississippi, Jackson, Mississippi., Gerhard GS; Department of Medical Genetics and Molecular Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania., Glümer C; Research Center for Prevention and Health, The Capital Region of Denmark, Glostrup University Hospital, Glostrup, Denmark., Gottesman O; The Charles Bronfman Institute for Personalized Medicine, and., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, and., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, and.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Harris TB; National Institutes on Aging, Bethesda, Maryland., Hayward C; Center for Genomic & Experimental Medicine, Institute of Genetics and Molecular Medicine.; Medical Research Council Human Genetics, Institute of Genetics and Molecular Medicine, and., Hocking L; Division of Applied Health Sciences, University of Aberdeen, Aberdeen, Scotland, United Kindom., Hofman A; Department of Epidemiology, and., Hu FB; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts., Husemoen LL; Research Center for Prevention and Health, The Capital Region of Denmark, Glostrup University Hospital, Glostrup, Denmark., Jackson RD; Department of Internal Medicine, The Ohio State University, Columbia, Ohio., Jørgensen T; Research Center for Prevention and Health, The Capital Region of Denmark, Glostrup University Hospital, Glostrup, Denmark., Jørgensen ME; Steno Diabetes Center, Gentofte, Denmark., Kähönen M; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Kardia SL; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan., König W; Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Ulm, Germany.; The German Heart Center Munich, Technical University of Munich, Munich, Germany.; German Center for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany., Kooperberg C; Fred Hutchinson Cancer Research Center, Seattle, Washington., Kriebel J; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Launer LJ; National Institutes on Aging, Bethesda, Maryland., Lauritzen T; Department of General Practice, Aarhus University, Aarhus, Denmark., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland., Levy D; National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts., Linksted P; Center for Genomic & Experimental Medicine, Institute of Genetics and Molecular Medicine., Linneberg A; Research Center for Prevention and Health, The Capital Region of Denmark, Glostrup University Hospital, Glostrup, Denmark.; Department of Clinical Experimental Research, Rigshospitalet, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Liu Y; Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina., Loos RJ; The Charles Bronfman Institute for Personalized Medicine, and., Lupo A; Renal Unit, Department of Medicine, University Hospital of Verona, Verona, Italy., Meisinger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Melander O; Department of Clinical Science, Lund University, Malmö, Sweden., Metspalu A; Estonian Genome Center of University of Tartu, Tartu, Estonia., Mitchell P; Center for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Westmead, Sydney, New South Wales, Australia., Nauck M; Institute of Clinical Chemistry and Laboratory Medicine.; German Center for Cardiovascular Research, partner site Greifswald, Greifswald, Germany., Nürnberg P; Cologne Center for Genomics, University of Cologne, Cologne, Germany., Orho-Melander M; Department of Clinical Science, Lund University, Malmö, Sweden., Parsa A; Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, and., Peters A; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Cardiovascular Disease Research, Munich, Germany., Peters U; Fred Hutchinson Cancer Research Center, Seattle, Washington., Polasek O; Center for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom., Porteous D; Center for Genomic & Experimental Medicine, Institute of Genetics and Molecular Medicine., Probst-Hensch NM; Swiss Tropical and Public Health Institute, Basel, Switzerland., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, and.; Departments of Epidemiology and Health Services, University of Washington, Seattle, Washington.; Group Health Research Institute, Group Health Cooperative, Seattle, Washington., Qi L; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, and Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Reiner AP; Fred Hutchinson Cancer Research Center, Seattle, Washington., Rettig R; Institute of Physiology, and., Ridker PM; Division of Preventive Medicine.; Cardiovascular Medicine Division, and., Rivadeneira F; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Rossouw JE; National Heart, Lung, and Blood Institute, Bethesda, Maryland., Schmidt F; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Siscovick D; Cardiovascular Health Research Unit, Department of Medicine, and., Soranzo N; Section of Biology and Genetics, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy., Strauch K; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany., Toniolo D; San Raffaele Scientific Institute, Milano, Italy., Turner ST; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota., Uitterlinden AG; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Ulivi S; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy., Velayutham D; Department of Health Science, University of Milano, Milano, Italy., Völker U; German Center for Cardiovascular Research, partner site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Völzke H; Institute for Community Medicine.; German Center for Cardiovascular Research, partner site Greifswald, Greifswald, Germany.; German Center for Diabetes Research, partner site Greifswald, Greifswald, Germany., Waldenberger M; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Wang JJ; Center for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Westmead, Sydney, New South Wales, Australia., Weir DR; Survey Research Center, Institute for Social Research, and., Witte D; Department of Public Health, Aarhus University, Aarhus, Denmark., Kuivaniemi H; The Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, Pennsylvania.; Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa., Fox CS; National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts., Franceschini N; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina., Goessling W; Genetics Division.; Steno Diabetes Center, Gentofte, Denmark.; Harvard Stem Cell Institute, Cambridge, Massachusetts; and.; Gastroenterology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Dana-Farber Cancer Institute, Boston, Massachusetts., Köttgen A; Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland; audrey.chu@nih.gov anna.koettgen@uniklinik-freiburg.de.; Division of Genetic Epidemiology, Medical Center - University of Freiburg, Freiburg, Germany., Chu AY; National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts; audrey.chu@nih.gov anna.koettgen@uniklinik-freiburg.de.; Division of Preventive Medicine.

Publikováno v: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2017 Mar; Vol. 28 (3), pp. 981-994. Date of Electronic Publication: 2016 Dec 05.