Prolonged Lipid Accumulation in Cultured Primary Human Hepatocytes Rather Leads to ER Stress than Oxidative Stress

Autor: Rennert, Christiane, Heil, Theresa, Schicht, Gerda, Stilkerich, Anna, Seidemann, Lena, Kegel-Hübner, Victoria, Seehofer, Daniel, Damm, Georg

Overweight has become a major health care problem in Western societies and is accompanied by an increasing incidence and prevalence of non-alcoholic fatty liver disease (NAFLD). The progression from NAFLD to non-alcoholic steatohepatitis (NASH) marks

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EFFECT OF GLUCOSE AND INSULIN SUPPLEMENTATION ON THE ISOLATION OF PRIMARY HUMAN HEPATOCYTES.

Autor: Damm, Georg^1,2,3 georg.damm@medizin.uni-leipzig.de, Schicht, Gerda^1,2, Zimmermann, Andrea^1,2, Rennert, Christiane^1,2, Fischer, Nicolas^1,2, Kießig, Melanie³, Wagner, Tristan¹, Kegel, Victoria^1,3, Seehofer, Daniel^1,3

Publikováno v: EXCLI Journal. 2019, Vol. 18, p1071-1091. 21p.

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Prolonged Lipid Accumulation in Cultured Primary Human Hepatocytes Rather Leads to ER Stress than Oxidative Stress.

Autor: Rennert C; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital, Leipzig University, 04103 Leipzig, Germany.; Saxonian Incubator for Clinical Translation (SIKT), Leipzig University, 04103 Leipzig, Germany., Heil T; Department of General-, Visceral- and Transplantation Surgery, Charité University Medicine Berlin, 13353 Berlin, Germany., Schicht G; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital, Leipzig University, 04103 Leipzig, Germany.; Saxonian Incubator for Clinical Translation (SIKT), Leipzig University, 04103 Leipzig, Germany., Stilkerich A; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital, Leipzig University, 04103 Leipzig, Germany.; Saxonian Incubator for Clinical Translation (SIKT), Leipzig University, 04103 Leipzig, Germany., Seidemann L; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital, Leipzig University, 04103 Leipzig, Germany., Kegel-Hübner V; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital, Leipzig University, 04103 Leipzig, Germany.; Department of General-, Visceral- and Transplantation Surgery, Charité University Medicine Berlin, 13353 Berlin, Germany., Seehofer D; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital, Leipzig University, 04103 Leipzig, Germany.; Department of General-, Visceral- and Transplantation Surgery, Charité University Medicine Berlin, 13353 Berlin, Germany., Damm G; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital, Leipzig University, 04103 Leipzig, Germany.; Saxonian Incubator for Clinical Translation (SIKT), Leipzig University, 04103 Leipzig, Germany.; Department of General-, Visceral- and Transplantation Surgery, Charité University Medicine Berlin, 13353 Berlin, Germany.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2020 Sep 26; Vol. 21 (19). Date of Electronic Publication: 2020 Sep 26.