USP1 deubiquitinates PARP1 to regulate its trapping and PARylation activity.

Autor: Nespolo A; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy., Stefenatti L; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy., Pellarin I; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy., Gambelli A; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy., Rampioni Vinciguerra GL; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy., Karimbayli J; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy., Barozzi S; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan (MI), Italy., Orsenigo F; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan (MI), Italy., Spizzo R; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy., Nicoloso MS; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy., Segatto I; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy., D'Andrea S; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy., Bartoletti M; Deparment of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy., Lucia E; Gynecological Surgery Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy., Giorda G; Gynecological Surgery Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy., Canzonieri V; Pathology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy.; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste (TS), Italy., Puglisi F; Deparment of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy.; Department of Medicine, University of Udine, Udine (UD), Italy., Belletti B; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy., Schiappacassi M; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy., Baldassarre G; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy., Sonego M; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy.

Publikováno v: Science advances [Sci Adv] 2024 Nov 15; Vol. 10 (46), pp. eadp6567. Date of Electronic Publication: 2024 Nov 13.

Molecular profiling of head and neck squamous cell carcinomas in North-eastern Italy identifies possible tumour cell vulnerabilities.

Autor: Schiappacassi M; Division of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini 2, Aviano (PN), 33081, Italy., Spizzo R; Division of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini 2, Aviano (PN), 33081, Italy., Polesel J; Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini 2, Aviano (PN), 33081, Italy., Musco L; Division of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini 2, Aviano (PN), 33081, Italy., Doliana R; Division of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini 2, Aviano (PN), 33081, Italy., Pellizzari L; Scientific Directorate, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini 2, Aviano (PN), 33081, Italy., Lupato V; Division of Otorhinolaryngology, Azienda Ospedaliera Santa Maria degli Angeli, via Montereale 24, 33170 Pordenone, Italy., Fanetti G; Department of Radiotherapy, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini 2, Aviano (PN), 33081, Italy., Vaccher E; Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini 2, Aviano (PN), 33081, Italy., Serraino D; Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini 2, Aviano (PN), 33081, Italy., Barzan L; Centro di Medicina, 33170 Pordenone, Italy., Sulfaro S; Division of Surgical Pathology, Azienda Ospedaliera Santa Maria degli Angeli, via Montereale 24, 33170 Pordenone, Italy., Giacomarra V; Division of Otorhinolaryngology, Azienda Ospedaliera Santa Maria degli Angeli, via Montereale 24, 33170 Pordenone, Italy., Franchin G; Department of Radiotherapy, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini 2, Aviano (PN), 33081, Italy., Baldassarre G; Division of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini 2, Aviano (PN), 33081, Italy. Electronic address: gbaldassarre@cro.it.

Publikováno v: Translational oncology [Transl Oncol] 2025 Jan; Vol. 51, pp. 102221. Date of Electronic Publication: 2024 Dec 01.

Platinum-induced upregulation of ITGA6 promotes chemoresistance and spreading in ovarian cancer.

Autor: Gambelli A; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., Nespolo A; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., Rampioni Vinciguerra GL; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy.; Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant'Andrea Hospital, University of Rome 'Sapienza', Rome, Italy., Pivetta E; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., Pellarin I; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., Nicoloso MS; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., Scapin C; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., Stefenatti L; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., Segatto I; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., Favero A; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., D'Andrea S; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., Mucignat MT; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., Bartoletti M; Deparment of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., Lucia E; Gynecological Surgery Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., Schiappacassi M; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., Spessotto P; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., Canzonieri V; Pathology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy.; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, TS, Italy., Giorda G; Gynecological Surgery Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., Puglisi F; Deparment of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy.; Department of Medicine, University of Udine, Udine, UD, Italy., Vecchione A; Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant'Andrea Hospital, University of Rome 'Sapienza', Rome, Italy., Belletti B; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., Sonego M; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy., Baldassarre G; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano, PN, Italy. gbaldassarre@cro.it.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2024 May; Vol. 16 (5), pp. 1162-1192. Date of Electronic Publication: 2024 Apr 24.

Case report: First evidence of impressive efficacy of modulated dose selpercatinib in a young Caucasian with ANK3-RET fusion-positive NSCLC.

Autor: De Carlo E; Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Aviano, Italy., Bertoli E; Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Aviano, Italy.; Department of Medicine (DAME), University of Udine, Udine, Italy., Schiappacassi M; Molecular Oncology Unit, Oncologia Molecolare e dei Modelli Preclinici di Progressione Tumorale (OMMPPT) Department of Translational Research, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy., Stanzione B; Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Aviano, Italy., Del Conte A; Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Aviano, Italy., Doliana R; Molecular Oncology Unit, Oncologia Molecolare e dei Modelli Preclinici di Progressione Tumorale (OMMPPT) Department of Translational Research, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy., Spina M; Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Aviano, Italy., Bearz A; Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Aviano, Italy.

Publikováno v: Frontiers in oncology [Front Oncol] 2024 Feb 07; Vol. 14, pp. 1307458. Date of Electronic Publication: 2024 Feb 07 (Print Publication: 2024).

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

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In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have als

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::b957db3260a0aea6fcc371a74c1cf1f4