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The metabolic effects of olanzapine and topiramate in rats and humans

Autor: Evers, S.S., van Dijk, G., van Vliet, A., Scheurink, A.J.W.

Publikováno v: Appetite, 57(Supplement 1). ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD

In humans the anti-psychotic Olanzapine (OLZ) has negative side effects on metabolism: it causes weight gain and increases the risk of developing type 2 Diabetes. The anti-convulsant Topiramate (TPM) has the opposite effects: it reduces body weight a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::f87273bee3f9d51542ac691efebebe54
https://research.rug.nl/en/publications/ab3fdcd3-7d9b-42a5-ac4f-aa04a94e65dc

AgRP(83—132) and SHU9119 differently affect activity-based anorexia

Autor: Kas, M.J.H., Hillebrand, J.J.G., Scheurink, A.J.W., Adan, R.A.H., Dijk, G. van

Publikováno v: European Neuropsychopharmacology. Elsevier

Activity-based anorexia (ABA) mimics starvation and hyperactivity of anorexia nervosa patients in rats. Activation of the melanocortin (MC) system leads to hypophagia and increased energy expenditure in ad libitum fed rats. Therefore, activation of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::501c63f84c1c5757c263d5cd1509218e
https://dspace.library.uu.nl/handle/1874/12095

Role of the leptin signaling system in energy homeostasis

Autor: Adan, R.A.H., Scheurink, A.J.W., Vaudry, H., Goos, H.J.Th., Rastogi, R.K., Pierantoni, R.

Publikováno v: Perspective in Comparative Endocrinology: Unity and Diversity., 693-701
STARTPAGE=693;ENDPAGE=701;TITLE=Perspective in Comparative Endocrinology: Unity and Diversity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::1835fe502d6c4e496cb2662a085dfd30
https://research.rug.nl/en/publications/45e7d932-6b4d-41cf-8471-f82da359bd70

Excessive portal venous supply of long-chain free fatty acids to the liver, leading to hypothalamus-pituitary-adrenal-axis and sympathetic activation as a key to the development of Syndrome X - A proposed concept for the induction of Syndrome X: A proposed concept for the induction of syndrome X

Autor: Benthem, L., Kuipers, F., Steffens, A.B., Scheurink, A.J.W., Hansen, BC, Saye, J, Wennogle, LP

Publikováno v: The Metabolic Syndrome X: Convergence of Insulin Resistance, Glucose Intolerance, Hypertension, Obesity, and Dyslipidemias-Searching for the Underlying Defects, 308-311
STARTPAGE=308;ENDPAGE=311;TITLE=The Metabolic Syndrome X

Insulin resistance and hypertension are two major symptoms of Syndrome X. A distinct relation between these symptoms and weight maintenance has been observed. Weight gain decreases insulin sensitivity and glucose tolerance and increases blood pressur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ef6164d2fba4fadc2b260776954fe8
https://research.rug.nl/en/publications/1b326ed3-f18e-4bf2-8cfe-c3fdcb646000