Intelligent ultrasonic-aspirator for CNS/ tumor tissue differentiation – a feasibility study using machine learning

Autor: Bockelmann, N, Schetelig, D, Bonsanto, MM, Buschschlüter, S, Ernst, F

Publikováno v: 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; 20220529-20220601; Köln; DOCV194 /20220525/

Objective: The goal of brain tumor surgery is the complete removal of all tumorous tissue while not damaging healthy, tumor-free brain areas. Therefore, emphasis must be placed on the intraoperative differentiation of brain tumors and healthy brain t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64af37bb4a4460fe44391d28cb6ed73

Toward intraoperative tissue classification: exploiting signal feedback from an ultrasonic aspirator for brain tissue differentiation.

Autor: Bockelmann N; Institute for Robotics and Cognitive Systems, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany. bockelmann@rob.uni-luebeck.de., Schetelig D; Söring GmbH, Justus-von-Liebig-Ring 2, 25451, Quickborn, Germany., Kesslau D; Söring GmbH, Justus-von-Liebig-Ring 2, 25451, Quickborn, Germany., Buschschlüter S; Söring GmbH, Justus-von-Liebig-Ring 2, 25451, Quickborn, Germany., Ernst F; Institute for Robotics and Cognitive Systems, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany., Bonsanto MM; Department of Neurosurgery, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, 23538, Lübeck, Germany.

Publikováno v: International journal of computer assisted radiology and surgery [Int J Comput Assist Radiol Surg] 2022 Sep; Vol. 17 (9), pp. 1591-1599. Date of Electronic Publication: 2022 Aug 04.

Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca ²⁺ signaling during T cell activation.

Autor: Gu F; Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Krüger A; Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Roggenkamp HG; Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Alpers R; Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Lodygin D; Institute for Neuroimmunology and Multiple Sclerosis Research, University Medical Center Göttingen, 37075 Göttingen, Germany., Jaquet V; Department of Pathology and Immunology, University of Geneva, 1211 Geneva 4, Switzerland., Möckl F; Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Hernandez C LC; Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Winterberg K; Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Bauche A; Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Rosche A; Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Grasberger H; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA., Kao JY; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA., Schetelig D; Department of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Werner R; Department of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Schröder K; Institute of Cardiovascular Physiology, Goethe-Universität, 60590 Frankfurt, Germany., Carty M; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Bowie AG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Huber S; Department of Gastroenterology with Sections Infectiology and Tropical Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Meier C; Organic Chemistry, University of Hamburg, 20146 Hamburg, Germany., Mittrücker HW; Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Heeren J; Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Krause KH; Department of Pathology and Immunology, University of Geneva, 1211 Geneva 4, Switzerland., Flügel A; Institute for Neuroimmunology and Multiple Sclerosis Research, University Medical Center Göttingen, 37075 Göttingen, Germany., Diercks BP; Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Guse AH; Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Publikováno v: Science signaling [Sci Signal] 2021 Nov 16; Vol. 14 (709), pp. eabe3800. Date of Electronic Publication: 2021 Nov 16.

HN1L/JPT2: A signaling protein that connects NAADP generation to Ca ²⁺ microdomain formation.

Autor: Roggenkamp HG; The Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Khansahib I; The Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Hernandez C LC; The Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Zhang Y; The Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Lodygin D; Institute for Neuroimmunology and Multiple Sclerosis Research, University Medical Centre Göttingen, 37075 Göttingen, Germany., Krüger A; The Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Gu F; The Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Möckl F; The Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Löhndorf A; The Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Wolters V; The Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Woike D; The Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Rosche A; The Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Bauche A; The Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Schetelig D; Department of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Werner R; Department of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Schlüter H; Mass Spectrometric Proteomics Group, Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Failla AV; Microscopy Imaging Facility (UMIF), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Meier C; Organic Chemistry, University of Hamburg, 20146 Hamburg, Germany., Fliegert R; The Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Walseth TF; Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455-0217, USA., Flügel A; Institute for Neuroimmunology and Multiple Sclerosis Research, University Medical Centre Göttingen, 37075 Göttingen, Germany., Diercks BP; The Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. guse@uke.de b.diercks@uke.de., Guse AH; The Ca Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. guse@uke.de b.diercks@uke.de.

Publikováno v: Science signaling [Sci Signal] 2021 Mar 23; Vol. 14 (675). Date of Electronic Publication: 2021 Mar 23.

ORAI1, STIM1/2, and RYR1 shape subsecond Ca ²⁺ microdomains upon T cell activation.

Autor: Diercks BP; The Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany., Werner R; Department of Computational Neuroscience, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany., Weidemüller P; The Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany., Czarniak F; The Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany., Hernandez L; The Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany., Lehmann C; The Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany., Rosche A; The Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany., Krüger A; The Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany., Kaufmann U; Department of Pathology, New York University School of Medicine, New York, NY 10016, USA., Vaeth M; Department of Pathology, New York University School of Medicine, New York, NY 10016, USA., Failla AV; Microscopy Core Facility, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany., Zobiak B; Microscopy Core Facility, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany., Kandil FI; Department of Computational Neuroscience, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany., Schetelig D; Department of Computational Neuroscience, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany., Ruthenbeck A; Organic Chemistry, University of Hamburg, 20146 Hamburg, Germany., Meier C; Organic Chemistry, University of Hamburg, 20146 Hamburg, Germany., Lodygin D; Institute of Neuroimmunology, University of Göttingen, 37075 Göttingen, Germany., Flügel A; Institute of Neuroimmunology, University of Göttingen, 37075 Göttingen, Germany., Ren D; Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6313, USA., Wolf IMA; The Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany., Feske S; Department of Pathology, New York University School of Medicine, New York, NY 10016, USA., Guse AH; The Calcium Signaling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany. guse@uke.de.

Publikováno v: Science signaling [Sci Signal] 2018 Dec 18; Vol. 11 (561). Date of Electronic Publication: 2018 Dec 18.