Immunoliposomes directed against colon adenocarcinoma cells: Delivery of 5-fluorodeoxyuridine to colon cancer cells and targeting to liver metastases

Autor: Kamps, JAAM, Morselt, HWM, Scherphof, GL, Koning, GA, Svenson, S

Publikováno v: POLYMERIC DRUG DELIVERY I: PARTICULATE DRUG CARRIERS, 84-94
STARTPAGE=84;ENDPAGE=94;TITLE=POLYMERIC DRUG DELIVERY I: PARTICULATE DRUG CARRIERS

Tumor cell-specific immunoliposomes have been applied to deliver a dipalmitoyl derivative of 5-fluorodeoxyuridine (FUdR-dP) to CC531 adenocarcinoma cells. Immunoliposomes containing FUdR-dP caused stronger inhibition of CC531 in vitro cell growth tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::54fb14b92d47d0c057501b288f7aa2f6
https://research.rug.nl/en/publications/60dbd180-661e-492f-9cdd-ad8bcc11e3f5

Interaction of differently designed immunoliposomes with colon cancer cells and Kupffer cells. An in vitro comparison

Autor: Koning, GA, Morselt, HWM, Gorter, A, Allen, TM, Zalipsky, S, Scherphof, GL, Kamps, JAAM

Publikováno v: Pharmaceutical Research, 20(8), 1249-1257. SPRINGER/PLENUM PUBLISHERS

Purpose. Evaluate the effectiveness of distal-end coupling of a tumor-specific antibody to liposomal polyethylene glycol (PEG) chains to improve target binding and reduce interference by macrophage uptake. Methods. Monoclonal antibody CC52, specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::1f88bd7ade8e90a1cf182fadb7b849fc
https://research.rug.nl/en/publications/0a26b7e2-d845-4da4-a1f2-1019ca4e5a49

Massive and selective delivery of lipid-coated cationic lipoplexes of oligonucleotides targeted in vivo to hepatic endothelial cells

Autor: Bartsch, M, Weeke-Klimp, AH, Meijer, DKF, Scherphof, GL, Kamps, JAAM

Publikováno v: Pharmaceutical Research, 19(5):UNSP 0724-8741/02/0500-0676/0, 676-680. SPRINGER/PLENUM PUBLISHERS

Purpose. Previously we reported on massive uptake of liposomes surface-modified with negatively charged aconitylated albumin (Aco-HSA) by liver sinusoidal endothelial cells (EC) in vivo. In the present work we applied this principle for the in vivo d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::acd295ab0ae0ea88e3d280df832ade79
https://research.rug.nl/en/publications/e109ef28-eaeb-4499-88f8-168a9b07381d

Development of liposomal gene targeting for therapeutic intervention or prevention of restenosis

Autor: Zant-Przeworska, E, Kamps, JAAM, Roks, AJM, Van Gilst, WH, Scherphof, GL

Publikováno v: Cellular & molecular biology letters, 7(2), 268-269

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::832d8b6f4d5c98f19a9314dd8d770566
https://research.rug.nl/en/publications/6acaef3c-ab3c-4538-b81b-9612125b1c22

Pharmacokinetics of differently designed immunoliposome formulations in rats with or without hepatic colon cancer metastases

Autor: Koning, GA, Morselt, HWM, Gorter, A, Allen, TM, Zalipsky, S, Kamps, JAAM, Scherphof, GL

Publikováno v: Pharmaceutical Research, 18(9), 1291-1298. SPRINGER/PLENUM PUBLISHERS

Purpose. Compare pharmacokinetics of tumor-directed immunoliposomes in healthy and tumor-bearing rats (hepatic colon. cancer metastases). Methods. A tumor cell-specific monoclonal antibody was attached to polyethyleneglycol-stabilized liposomes, eith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::862a412d0b50582b041926dc08eb2a6c
https://research.rug.nl/en/publications/6351b190-db2f-4080-b7a6-51ede2f04ff2