In silico and in vitro evaluation of efflux pumps inhibition of α,β-amyrin.

Autor: Oliveira RC; Graduate Program in Biological Chemistry, Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Bandeira PN; Science and Technology Centre, Course of Chemistry, State University Vale do Acaraú, Sobral, CE, Brazil., Lemos TLG; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, CE, Brazil., Dos Santos HS; Graduate Program in Biological Chemistry, Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.; Science and Technology Centre, Course of Chemistry, State University Vale do Acaraú, Sobral, CE, Brazil., Scherf JR; Graduate Program in Biological Chemistry, Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Rocha JE; Graduate Program in Biological Chemistry, Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Pereira RLS; Graduate Program in Biological Chemistry, Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Freitas TS; Graduate Program in Biological Chemistry, Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Freitas PR; Graduate Program in Biological Chemistry, Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Pereira-Junior FN; Center of Agricultural Sciences and of the Biodiversity, Federal University of Cariri, Juazeiro do Norte, CE, Brazil., Marinho MM; Faculty of Education, Sciences and Letters of Iguatu, State University of Ceará, Campus FECLI, Iguatu, CE, Brazil., Marinho EM; Department of Analytical Chemistry and Physical Chemistry, Federal University of Ceará, Fortaleza, CE, Brazil., Marinho ES; Group of Theoretical Chemistry and Electrochemistry, State University of Ceará, Campus FAFIDAM, Limoeiro do Norte, CE, Brazil., Nogueira CES; Graduate Program in Biological Chemistry, Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.; Department of Physics, Regional University of Cariri, Juazeiro do Norte, CE, Brazil., Coutinho HDM; Graduate Program in Biological Chemistry, Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil., Teixeira AMR; Graduate Program in Biological Chemistry, Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.; Department of Physics, Regional University of Cariri, Juazeiro do Norte, CE, Brazil.

Publikováno v: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2022; Vol. 40 (23), pp. 12785-12799. Date of Electronic Publication: 2021 Sep 16.

Effect of Carvacrol and Thymol on NorA efflux pump inhibition in multidrug-resistant (MDR) Staphylococcus aureus strains.

Autor: Dos Santos Barbosa CR; Laboratory of Semi-Arid Bioprospecting (LABSEMA), Regional University of Cariri-URCA, Crato, Brazil. hdmcoutinho@gmail.com., Scherf JR; Laboratory of Semi-Arid Bioprospecting (LABSEMA), Regional University of Cariri-URCA, Crato, Brazil., de Freitas TS; Laboratory of Simulations and Molecular Spectroscopy (Lasemol), Regional University of Cariri-URCA, Crato, Brazil., de Menezes IRA; Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry, Regional University of Cariri-URCA, Crato, Brazil., Pereira RLS; Laboratory of Simulations and Molecular Spectroscopy (Lasemol), Regional University of Cariri-URCA, Crato, Brazil., Dos Santos JFS; Laboratory of Semi-Arid Bioprospecting (LABSEMA), Regional University of Cariri-URCA, Crato, Brazil., de Jesus SSP; Laboratory of Semi-Arid Bioprospecting (LABSEMA), Regional University of Cariri-URCA, Crato, Brazil., Lopes TP; Laboratory of Semi-Arid Bioprospecting (LABSEMA), Regional University of Cariri-URCA, Crato, Brazil., de Sousa Silveira Z; Laboratory of Semi-Arid Bioprospecting (LABSEMA), Regional University of Cariri-URCA, Crato, Brazil., de Morais Oliveira-Tintino CD; Laboratory of Pharmacotoxicological Prospection of Bioactive Products (Biofarmatox), Federal University of Pernambuco-UFPE, Recife, Brazil., Júnior JPS; Laboratory of Microorganism Genetics (LGM), Federal University of Paraiba-UFPB, João Pessoa, Brazil., Coutinho HDM; Laboratory of Microbiology and Molecular Biology (LMBM), Regional University of Cariri-URCA, Crato, Brazil. hdmcoutinho@gmail.com., Tintino SR; Laboratory of Microbiology and Molecular Biology (LMBM), Regional University of Cariri-URCA, Crato, Brazil., da Cunha FAB; Laboratory of Semi-Arid Bioprospecting (LABSEMA), Regional University of Cariri-URCA, Crato, Brazil. cunha.urca@gmail.com.

Publikováno v: Journal of bioenergetics and biomembranes [J Bioenerg Biomembr] 2021 Aug; Vol. 53 (4), pp. 489-498. Date of Electronic Publication: 2021 Jun 22.

Effect of terpinolene against the resistant Staphylococcus aureus strain, carrier of the efflux pump QacC and β-lactamase gene, and its toxicity in the Drosophila melanogaster model.

Autor: Scherf JR; Laboratory of Bioprospecting in the Semi-Arid and Alternative Methods (LABSEMA), Regional University of Cariri - URCA, Crato, 63105-000, CE, Brazil; Biological Chemistry Pos Graduate Program, Brazil. Electronic address: jackelyne_scherf@yahoo.com.br., Barbosa Dos Santos CR; Laboratory of Bioprospecting in the Semi-Arid and Alternative Methods (LABSEMA), Regional University of Cariri - URCA, Crato, 63105-000, CE, Brazil; Biological Chemistry Pos Graduate Program, Brazil. Electronic address: cristinase75@gmail.com., Sampaio de Freitas T; Laboratory of Simulations and Molecular Spectroscopy, Regional University of Cariri - URCA, Crato, 63105-000, CE, Brazil; Biological Chemistry Pos Graduate Program, Brazil. Electronic address: thiagocrato@hotmail.com., Rocha JE; Laboratory of Microbiology and Molecular Biology (LMBM), Regional University of Cariri - URCA, Crato, 63105-000, CE, Brazil; Biological Chemistry Pos Graduate Program, Brazil. Electronic address: janainaesmeraldo@gmail.com., Macêdo NS; Laboratory of Bioprospecting in the Semi-Arid and Alternative Methods (LABSEMA), Regional University of Cariri - URCA, Crato, 63105-000, CE, Brazil; Biological Sciences Pos Graduate Program - PPGCB, Federal University of Pernambuco - UFPE, Recife, 50670-901, PE, Brazil. Electronic address: naiirmacedo@gmail.com., Mascarenhas Lima JN; Laboratory of Bioprospecting in the Semi-Arid and Alternative Methods (LABSEMA), Regional University of Cariri - URCA, Crato, 63105-000, CE, Brazil. Electronic address: jessyca.lima@urca.br., Melo Coutinho HD; Laboratory of Microbiology and Molecular Biology (LMBM), Regional University of Cariri - URCA, Crato, 63105-000, CE, Brazil., Bezerra da Cunha FA; Laboratory of Bioprospecting in the Semi-Arid and Alternative Methods (LABSEMA), Regional University of Cariri - URCA, Crato, 63105-000, CE, Brazil. Electronic address: cunha.urca@gmail.com.

Publikováno v: Microbial pathogenesis [Microb Pathog] 2020 Dec; Vol. 149, pp. 104528. Date of Electronic Publication: 2020 Sep 28.