Výsledky vyhledávání

Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation

Autor: Nayak RR, Alexander M, Deshpande I, Stapleton-Gray K, Rimal B, Patterson AD, Ubeda C, Scher JU, Turnbaugh PJ

Publikováno v: CELL HOST MICROBE
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
CELL HOST & MICROBE
r-FISABIO. Repositorio Institucional de Producción Científica
Fundación Universitaria San Pablo CEU (FUSPCEU)

Immunomodulatory drugs can inhibit bacterial growth, yet their mechanism of action, spectrum, and clinical relevance remain unknown. Methotrexate (MTX), a first-line rheumatoid arthritis (RA) treatment, inhibits mammalian dihydrofolate reductase (DHF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9cdbc58041bed84a6731b1d784da55f8
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=8744

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Pharmacomicrobiomics in inflammatory arthritis: gut microbiome as modulator of therapeutic response

Autor: Scher JU, Nayak RR, Ubeda C, Turnbaugh PJ, Abramson SB

Publikováno v: NATURE REVIEWS RHEUMATOLOGY
r-FISABIO. Repositorio Institucional de Producción Científica
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r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)

In the past three decades, extraordinary advances have been made in the understanding of the pathogenesis of, and treatment options for, inflammatory arthritides, including rheumatoid arthritis and spondyloarthritis. The use of methotrexate and subse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2aff6522aa1843c414d34385fd066b9d
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=7212

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Gut Microbiota Perturbations in Reactive Arthritis and Postinfectious Spondyloarthritis

Autor: Manasson J, Shen N, Garcia Ferrer HR, Ubeda C, Iraheta I, Heguy A, Von Feldt JM, Espinoza LR, Kutzbach AG, Segal LN, Ogdie A, Clemente JC, Scher JU

Publikováno v: ARTHRITIS & RHEUMATOLOGY
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-FISABIO. Repositorio Institucional de Producción Científica
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Objective. Reactive arthritis (ReA) is an inflammatory disorder occurring several weeks after gastrointestinal or genitourinary tract infections. HLA-B27 positivity is considered a risk factor, although it is not necessarily predictive of disease inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3d88c6333bc839a6c2ec47258895217f
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=2314

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Short- and long-term effects of oral vancomycin on the human intestinal microbiota

Autor: Isaac S, Scher JU, Djukovic A, Jiménez N, Littman DR, Abramson SB, Pamer EG, Ubeda C

Publikováno v: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)

Background: Oral vancomycin remains the mainstay of therapy for severe infections produced by Clostridium difficile, the most prevalent cause of healthcare-associated infectious diarrhoea in developed countries. However, its short-and long-term effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::93f05506f375e855c4ef95ee7e175236
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=1427

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Gut-Brain Axis Dysfunction May Be Associated With Psoriatic Arthritis: Comment on the Article by Scher et al Reply

Autor: Scher JU, Reddy S, Ubeda C, Neimann A, Abramson SB

Publikováno v: ARTHRITIS & RHEUMATOLOGY
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c577d40ee3de45c8c13669ad053310af
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=8578

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Decreased Bacterial Diversity Characterizes the Altered Gut Microbiota in Patients With Psoriatic Arthritis, Resembling Dysbiosis in Inflammatory Bowel Disease

Autor: Scher JU, Ubeda C, Artacho A, Attur M, Isaac S, Reddy SM, Marmon S, Neimann A, Brusca S, Patel T, Manasson J, Pamer EG, Littman DR, Abramson SB

Objective. To characterize the diversity and taxonomic relative abundance of the gut microbiota in patients with never-treated, recent-onset psoriatic arthritis (PsA). Methods. High-throughput 16S ribosomal RNA pyrosequencing was utilized to compare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b4ad1bd8b93c03762932cce60aaff921
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=8579

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Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

Autor: Scher, JU, Sczesnak, A, Longman, RS, Segata, N, Ubeda, C, Bielski, C, Rostron, T, Cerundolo, V, Pamer, EG, Abramson, SB, Huttenhower, C, Littman, DR

Publikováno v: eLife. 2013(2)

Rheumatoid arthritis (RA) is a prevalent systemic autoimmune disease, caused by a combination of genetic and environmental factors. Animal models suggest a role for intestinal bacteria in supporting the systemic immune response required for joint inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::ddf87d6d1d9ae6817032c9cb4fb6c605
http://ora.ox.ac.uk/objects/uuid:c63a0a59-1008-435d-8fdf-e5a23aeee579