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Akademický článek

Folates and antifolates in rheumatoid arthritis

Autor: Jansen Gerrit, Weijers Karin, Blits Marjolein, van der Heijden Joost, Gent Yoony, Al Marjon, van der Laken Conny, Molthoff Carla, Verweij Cor, Voskuijl Alexandre, Lems Willem, Scheper Rik, Peters Godefridus, Ratnam Manohar, Aassaraf Yehuda, Dijkmans Ben

Publikováno v: Pteridines, Vol 24, Iss 1, Pp 21-26 (2013)

Almost all current standard treatment of care for patients with chronic inflammatory diseases such as rheumatoid arthritis (RA) includes the folate antagonist methotrexate (MTX). Despite the proven efficacy of MTX in RA treatment, it is anticipated t

Externí odkaz: https://doaj.org/article/e593d5a56a1546ec9a04bf4a34f6331d

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Akademický článek

Overcoming bortezomib resistance in human B cells by anti-CD20/rituximab-mediated complement-dependent cytotoxicity and epoxyketone-based irreversible proteasome inhibitors

Autor: Verbrugge Sue Ellen, Al Marjon, Assaraf Yehuda G, Niewerth Denise, van Meerloo Johan, Cloos Jacqueline, van der Veer Michael, Scheffer George L, Peters Godefridus J, Chan Elena T, Anderl Janet L, Kirk Christopher J, Zweegman Sonja, Dijkmans Ben AC, Lems Willem F, Scheper Rik J, de Gruijl Tanja D, Jansen Gerrit

Publikováno v: Experimental Hematology & Oncology, Vol 2, Iss 1, p 2 (2013)

Abstract Background In clinical and experimental settings, antibody-based anti-CD20/rituximab and small molecule proteasome inhibitor (PI) bortezomib (BTZ) treatment proved effective modalities for B cell depletion in lymphoproliferative disorders as

Externí odkaz: https://doaj.org/article/a6fa0811b477498ca69c0bc081ec176b

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Akademický článek

Defining the critical hurdles in cancer immunotherapy

Autor: Fox Bernard A, Schendel Dolores J, Butterfield Lisa H, Aamdal Steinar, Allison James P, Ascierto Paolo, Atkins Michael B, Bartunkova Jirina, Bergmann Lothar, Berinstein Neil, Bonorino Cristina C, Borden Ernest, Bramson Jonathan L, Britten Cedrik M, Cao Xuetao, Carson William E, Chang Alfred E, Characiejus Dainius, Choudhury A Raja, Coukos George, de Gruijl Tanja, Dillman Robert O, Dolstra Harry, Dranoff Glenn, Durrant Lindy G, Finke James H, Galon Jerome, Gollob Jared A, Gouttefangeas Cécile, Grizzi Fabio, Guida Michele, Håkansson Leif, Hege Kristen, Herberman Ronald B, Hodi F Stephen, Hoos Axel, Huber Christoph, Hwu Patrick, Imai Kohzoh, Jaffee Elizabeth M, Janetzki Sylvia, June Carl H, Kalinski Pawel, Kaufman Howard L, Kawakami Koji, Kawakami Yutaka, Keilholtz Ulrich, Khleif Samir N, Kiessling Rolf, Kotlan Beatrix, Kroemer Guido, Lapointe Rejean, Levitsky Hyam I, Lotze Michael T, Maccalli Cristina, Maio Michele, Marschner Jens-Peter, Mastrangelo Michael J, Masucci Giuseppe, Melero Ignacio, Melief Cornelius, Murphy William J, Nelson Brad, Nicolini Andrea, Nishimura Michael I, Odunsi Kunle, Ohashi Pamela S, O'Donnell-Tormey Jill, Old Lloyd J, Ottensmeier Christian, Papamichail Michael, Parmiani Giorgio, Pawelec Graham, Proietti Enrico, Qin Shukui, Rees Robert, Ribas Antoni, Ridolfi Ruggero, Ritter Gerd, Rivoltini Licia, Romero Pedro J, Salem Mohamed L, Scheper Rik J, Seliger Barbara, Sharma Padmanee, Shiku Hiroshi, Singh-Jasuja Harpreet, Song Wenru, Straten Per, Tahara Hideaki, Tian Zhigang, van Der Burg Sjoerd H, von Hoegen Paul, Wang Ena, Welters Marij JP, Winter Hauke, Withington Tara, Wolchok Jedd D, Xiao Weihua, Zitvogel Laurence, Zwierzina Heinz, Marincola Francesco M, Gajewski Thomas F, Wigginton Jon M, Disis Mary L

Publikováno v: Journal of Translational Medicine, Vol 9, Iss 1, p 214 (2011)

Abstract Scientific discoveries that provide strong evidence of antitumor effects in preclinical models often encounter significant delays before being tested in patients with cancer. While some of these delays have a scientific basis, others do not.

Externí odkaz: https://doaj.org/article/a5cf6b0d55484f40a970d9cfef5d3474

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Akademický článek

Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice

Autor: Postma Dirkje S, Scheper Rik J, van der Strate Barry W, Timmer-Bosscha Hetty, Timens Wim, van der Deen Margaretha, de Vries Elisabeth G, Kerstjens Huib A

Publikováno v: Respiratory Research, Vol 8, Iss 1, p 49 (2007)

Abstract Background Tobacco smoke is the principal risk factor for chronic obstructive pulmonary disease (COPD), though the mechanisms of its toxicity are still unclear. The ABC transporters multidrug resistance-associated protein 1 (MRP1) and P-glyc

Externí odkaz: https://doaj.org/article/fcb890be65634dd9b201c95f1a674120

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Akademický článek

ATP-binding cassette (ABC) transporters in normal and pathological lung

Autor: Timmer-Bosscha Hetty, Scheper Rik J, Timens Wim, de Vries Elisabeth GE, van der Deen Margaretha, Postma Dirkje S

Publikováno v: Respiratory Research, Vol 6, Iss 1, p 59 (2005)

Abstract ATP-binding cassette (ABC) transporters are a family of transmembrane proteins that can transport a wide variety of substrates across biological membranes in an energy-dependent manner. Many ABC transporters such as P-glycoprotein (P-gp), mu

Externí odkaz: https://doaj.org/article/ac8596ed845a442d83d542f44b9955d6

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