Longitudinal Intravascular Antibody Labeling Identified Regulatory T Cell Recruitment as a Therapeutic Target in a Mouse Model of Lung Cancer.

Autor: Shanahan SL; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA., Kunder N; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX., Inaku C; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX., Hagan NB; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX., Gibbons G; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA., Mathey-Andrews N; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA.; Harvard Medical School, Boston, MA., Anandappa G; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX., Soares S; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA., Pauken KE; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX., Jacks T; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA., Schenkel JM; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA.; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX.; Harvard Medical School, Boston, MA.; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX.; Department of Pathology, Brigham and Women's Hospital, Boston, MA.; Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2024 Sep 15; Vol. 213 (6), pp. 906-918.

Tissue-resident memory T cells trigger rapid exudation and local antibody accumulation.

Autor: Rosato PC; University of Minnesota, Center for Immunology, Department of Microbiology and Immunology, Minneapolis, MN, USA; Geisel School of Medicine at Dartmouth College, Dartmouth Cancer Center, Department of Microbiology and Immunology, Lebanon, NH, USA., Lotfi-Emran S; University of Minnesota, Center for Immunology, Department of Microbiology and Immunology, Minneapolis, MN, USA., Joag V; University of Minnesota, Center for Immunology, Department of Microbiology and Immunology, Minneapolis, MN, USA., Wijeyesinghe S; University of Minnesota, Center for Immunology, Department of Microbiology and Immunology, Minneapolis, MN, USA., Quarnstrom CF; University of Minnesota, Center for Immunology, Department of Microbiology and Immunology, Minneapolis, MN, USA., Degefu HN; Geisel School of Medicine at Dartmouth College, Dartmouth Cancer Center, Department of Microbiology and Immunology, Lebanon, NH, USA., Nedellec R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Schenkel JM; University of Minnesota, Center for Immunology, Department of Microbiology and Immunology, Minneapolis, MN, USA., Beura LK; University of Minnesota, Center for Immunology, Department of Microbiology and Immunology, Minneapolis, MN, USA; Brown University, Department of Molecular Microbiology and Immunology, Providence, RI, USA., Hangartner L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Masopust D; University of Minnesota, Center for Immunology, Department of Microbiology and Immunology, Minneapolis, MN, USA. Electronic address: masopust@umn.edu.

Publikováno v: Mucosal immunology [Mucosal Immunol] 2023 Feb; Vol. 16 (1), pp. 17-26. Date of Electronic Publication: 2023 Jan 16.

Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.

Autor: Hwang WL; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Jagadeesh KA; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Guo JA; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; School of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA, USA., Hoffman HI; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Harvard-MIT MD/PhD and Health Sciences and Technology Program, Harvard Medical School, Boston, MA, USA., Yadollahpour P; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Reeves JW; NanoString Technologies, Seattle, WA, USA., Mohan R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Drokhlyansky E; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Van Wittenberghe N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ashenberg O; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Farhi SL; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Schapiro D; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Institute for Computational Biomedicine and Institute of Pathology, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany., Divakar P; NanoString Technologies, Seattle, WA, USA., Miller E; NanoString Technologies, Seattle, WA, USA., Zollinger DR; NanoString Technologies, Seattle, WA, USA., Eng G; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Schenkel JM; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Su J; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Shiau C; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yu P; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Freed-Pastor WA; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Abbondanza D; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mehta A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Gould J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lambden C; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Porter CBM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tsankov A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dionne D; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Waldman J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cuoco MS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nguyen L; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Delorey T; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Phillips D; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Barth JL; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Kem M; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Rodrigues C; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ciprani D; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Roldan J; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Zelga P; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Jorgji V; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Chen JH; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ely Z; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Zhao D; New York Medical College, Valhalla, NY, USA., Fuhrman K; NanoString Technologies, Seattle, WA, USA., Fropf R; NanoString Technologies, Seattle, WA, USA., Beechem JM; NanoString Technologies, Seattle, WA, USA., Loeffler JS; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ryan DP; Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Weekes CD; Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ferrone CR; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Qadan M; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Aryee MJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Jain RK; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Neuberg DS; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Wo JY; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Hong TS; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Xavier R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Aguirre AJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Rozenblatt-Rosen O; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Mino-Kenudson M; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Castillo CF; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Liss AS; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ting DT; Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Jacks T; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. aviv.regev.sc@gmail.com., Regev A; Broad Institute of MIT and Harvard, Cambridge, MA, USA. tjacks@mit.edu.; Genentech, South San Francisco, CA, USA. tjacks@mit.edu.

Publikováno v: Nature genetics [Nat Genet] 2022 Aug; Vol. 54 (8), pp. 1178-1191. Date of Electronic Publication: 2022 Jul 28.

Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities.

Autor: Shi DD; Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, USA., Guo JA; Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Boston, MA, USA; School of Medicine, University of California, San Francisco, San Francisco, CA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Biological and Biomedical Sciences Program, Harvard University, Boston, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Hoffman HI; Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biology, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Harvard-MIT Health Sciences and Technology Program, Harvard Medical School, Boston, MA, USA., Su J; Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biology, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Mino-Kenudson M; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Barth JL; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Schenkel JM; Department of Biology, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Loeffler JS; Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Boston, MA, USA., Shih HA; Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Boston, MA, USA., Hong TS; Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Boston, MA, USA., Wo JY; Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Boston, MA, USA., Aguirre AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Jacks T; Department of Biology, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Zheng L; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Wen PY; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Wang TC; Division of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY, USA., Hwang WL; Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biology, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: whwang1@mgh.harvard.edu.

Publikováno v: The Lancet. Oncology [Lancet Oncol] 2022 Feb; Vol. 23 (2), pp. e62-e74.

Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1 ⁺ CD8 ⁺ T cells in tumor-draining lymph nodes.

Autor: Schenkel JM; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA., Herbst RH; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA., Canner D; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA., Li A; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA., Hillman M; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA., Shanahan SL; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA., Gibbons G; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA., Smith OC; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA., Kim JY; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA., Westcott P; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA., Hwang WL; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Department of Radiation Oncology, Massachusetts General Hospital, Boston MA 02114., Freed-Pastor WA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Eng G; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Cuoco MS; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA., Rogers P; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA., Park JK; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA., Burger ML; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA., Rozenblatt-Rosen O; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA., Cong L; Departments of Pathology, Stanford University, Stanford, CA 94305, USA., Pauken KE; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA., Regev A; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: aviv.regev.sc@gmail.com., Jacks T; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: tjacks@mit.edu.

Publikováno v: Immunity [Immunity] 2021 Oct 12; Vol. 54 (10), pp. 2338-2353.e6. Date of Electronic Publication: 2021 Sep 16.