Efficient flavinylation of glycosomal fumarate reductase by its own ApbE domain in Trypanosoma brucei.

Autor: Schenk, Robin¹ (AUTHOR), Bachmaier, Sabine¹ (AUTHOR), Bringaud, Frédéric² (AUTHOR), Boshart, Michael¹ (AUTHOR) boshart@lmu.de

Publikováno v: FEBS Journal. Sep2021, Vol. 288 Issue 18, p5430-5445. 16p.

Metabolic selection of a homologous recombination-mediated gene loss protects Trypanosoma brucei from ROS production by glycosomal fumarate reductase

Autor: Wargnies, Marion, Plazolles, Nicolas, Schenk, Robin, Villafraz, Oriana, Dupuy, Jean-William, Biran, Marc, Bachmaier, Sabine, Baudouin, Hélène, Clayton, Christine, Boshart, Michael, Bringaud, Frédéric

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 296, pp.100548. ⟨10.1016/j.jbc.2021.100548⟩
The Journal of Biological Chemistry

International audience; The genome of trypanosomatids rearranges by using repeated sequences as platforms for amplification or deletion of genomic segments. These stochastic recombination events have a direct impact on gene dosage and foster the sele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::432b54ef02595b3c3feb09753cee04e9
https://hal.archives-ouvertes.fr/hal-03216701

Metabolic selection of a homologous recombination-mediated gene loss protects Trypanosoma brucei from ROS production by glycosomal fumarate reductase.

Autor: Wargnies M; Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France; Univ. Bordeaux, CNRS, Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB), UMR 5536, Bordeaux, France., Plazolles N; Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France., Schenk R; Fakultät für Biologie, Genetik, Ludwig-Maximilians-Universität München, Martinsried, Germany., Villafraz O; Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France., Dupuy JW; Univ. Bordeaux, Plateforme Protéome, Bordeaux, France., Biran M; Univ. Bordeaux, CNRS, Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB), UMR 5536, Bordeaux, France., Bachmaier S; Fakultät für Biologie, Genetik, Ludwig-Maximilians-Universität München, Martinsried, Germany., Baudouin H; Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France; Univ. Bordeaux, CNRS, Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB), UMR 5536, Bordeaux, France., Clayton C; Zentrum für Molekulare Biologie der Universität Heidelberg (ZBMH), Universität Heidelberg, Heidelberg, Germany., Boshart M; Fakultät für Biologie, Genetik, Ludwig-Maximilians-Universität München, Martinsried, Germany. Electronic address: boshart@lmu.de., Bringaud F; Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France; Univ. Bordeaux, CNRS, Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB), UMR 5536, Bordeaux, France. Electronic address: frederic.bringaud@u-bordeaux.fr.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100548. Date of Electronic Publication: 2021 Mar 17.