Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Schelkun Robert Michael"'
Autor:
Lawrence D. Wise, Po-Wai Yuen, Leonard T. Meltzer, Schelkun Robert Michael, Edward R. Whittemore, Kevin A. Serpa, Richard M. Woodward
Publikováno v:
Journal of Medicinal Chemistry. 43:1892-1897
Previous work in our laboratories investigating compounds with structural similarity to ifenprodil (5) and 6 (CP101,606) resulted in compound 7 as a potent and selective antagonist of the NR1/2B subtype of the NMDA receptors. Replacement of the pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35cc8fe32ce57e06aa96dcbad34f80a
https://doi.org/10.1021/jm990537r
https://doi.org/10.1021/jm990537r
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:2415-2418
Voltage Activated Calcium Channel (VACC) blockers have been demonstrated to have utility in the treatment of pain and stroke. A series of aminomethyl substituted isoquinolinol derivatives with potent functional activity for N-type VACC's have been id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46cb1702e5628b4e20c47c607aac994
https://doi.org/10.1016/s0960-894x(98)00440-5
https://doi.org/10.1016/s0960-894x(98)00440-5
Autor:
Daniel F. Ortwine, Peter A. Boxer, Leonard Joseph Lescosky, S. A. Borosky, Daniel Martin Retz, C.B. Nelson, Thomas Charles Malone, Christopher F. Bigge, Mark G. Vartanian, Schelkun Robert Michael
Publikováno v:
Journal of Medicinal Chemistry. 38:3720-3740
Four related series of substituted quinoxalinediones containing angular fused-piperidine rings have been synthesized as α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists with potential as neuroprotective agents, primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe1f78653faecd9283d29ff86e0bbd8
https://doi.org/10.1021/jm00019a003
https://doi.org/10.1021/jm00019a003
Autor:
Mark G. Vartanian, Gregory W. Campbell, Christopher F. Bigge, Daniel F. Ortwine, Roy D. Schwarz, Peter A. Boxer, Schelkun Robert Michael, Lillian J. Robichaud, S. A. Borosky, D. M. Retz, Thomas Charles Malone, Leonard Joseph Lescosky, F. Waetjen, C.B. Nelson
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba446b1cb6d0230e4edfbb4863c69962
https://doi.org/10.1002/chin.199603167
https://doi.org/10.1002/chin.199603167
Autor:
John F. W. Keana, Eckard Weber, Po-Wai Yuen, Amir P. Tamiz, Edward R. Whittemore, Schelkun Robert Michael, Sui Xiong Cai, Richard M. Woodward
Publikováno v:
ChemInform. 29
A series of N-(2-phenethyl)cinnamides was synthesized and assayed for antagonism at three N-methyl-D-asparate (NMDA) receptor subtypes (NR1A/2A-C). N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide (6) was identified as a highly potent and selective ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fbbf32d74b2c5651fbaba5394ec18e1
https://doi.org/10.1002/chin.199818104
https://doi.org/10.1002/chin.199818104
Publikováno v:
ChemInform. 30
Voltage Activated Calcium Channel (VACC) blockers have been demonstrated to have utility in the treatment of pain and stroke. A series of aminomethyl substituted isoquinolinol derivatives with potent functional activity for N-type VACC's have been id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::533538538608e1f8d45b9ff865179501
https://doi.org/10.1002/chin.199902147
https://doi.org/10.1002/chin.199902147
Autor:
Schelkun Robert Michael, Kevin A. Serpa, Po-Wai Yuen, Leonard T. Meltzer, Richard M. Woodward, Lawrence D. Wise, Edward R. Whittemore
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f92e73d9025afe427e9bc4137adfd76
https://doi.org/10.1002/chin.200031147
https://doi.org/10.1002/chin.200031147
Autor:
Ti-Zhi Su, Jack J. Kinsora, David J. Wustrow, Po-Wai Yuen, Mark G. Vartanian, Schelkun Robert Michael
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(9)
A series of heteroaromatic analogs of pregabalin has been identified that possess anticonvulsant activity in the DBA/2 mouse model. The methods of synthesis and preliminary pharmacology are discussed herein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d300c0a7f0c1bd5f002661275f3f76
https://pubmed.ncbi.nlm.nih.gov/16099652
https://pubmed.ncbi.nlm.nih.gov/16099652
Autor:
David M. Rock, Po-Wai Yuen, Sally J. Stoehr, Schelkun Robert Michael, Balazs G. Szoke, Thomas Charles Malone, Katalin Tarczy-Hornoch
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(16)
Voltage activated calcium channel (VACC) blockers have been demonstrated to have utility in the treatment of stroke and pain. A series of aminomethyl substituted phenol derivatives has been identified with good functional activity and selectivity for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457c485411969b40711012f0001ff6e2
https://pubmed.ncbi.nlm.nih.gov/10476885
https://pubmed.ncbi.nlm.nih.gov/10476885
Autor:
Sui Xiong Cai, John F. W. Keana, Eckard Weber, Amir P. Tamiz, Po-Wai Yuen, Edward R. Whittemore, Schelkun Robert Michael, Richard M. Woodward
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:199-200
A series of N-(2-phenethyl)cinnamides was synthesized and assayed for antagonism at three N-methyl-D-asparate (NMDA) receptor subtypes (NR1A/2A-C). N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide (6) was identified as a highly potent and selective ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7cc4e3c4a3f22d01f9bf1417409bd3e
https://doi.org/10.1016/s0960-894x(97)10215-3
https://doi.org/10.1016/s0960-894x(97)10215-3