Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Scheherazade Sadegh-Nasseri"'
Autor:
Chan-Su Park, Jian Guan, Peter Rhee, Federico Gonzalez, Hee-sung Lee, Ji-hyun Park, Laurent Coscoy, Ellen A Robey, Nilabh Shastri, Scheherazade Sadegh-Nasseri
Publikováno v:
eLife, Vol 13 (2024)
The fate of developing T cells is determined by the strength of T cell receptor (TCR) signal they receive in the thymus. This process is finely regulated through the tuning of positive and negative regulators in thymocytes. The Family with sequence s
Externí odkaz:
https://doaj.org/article/5dac43e64dda4b1c805566d173e337bf
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Regulatory T cells (Treg) are crucial immune modulators, yet the exact mechanism of thymic Treg development remains controversial. Here, we present the first direct evidence for H2-O, an MHC class II peptide editing molecular chaperon, on selection o
Externí odkaz:
https://doaj.org/article/f15013f2bbe74e1aa7b4a70190f11ecd
Autor:
Jian Guan, J David Peske, Michael Manoharan Valerio, Chansu Park, Ellen A Robey, Scheherazade Sadegh-Nasseri
Publikováno v:
eLife, Vol 12 (2023)
Intestinal intraepithelial lymphocytes (IELs) are characterized by an unusual phenotype and developmental pathway, yet their specific ligands and functions remain largely unknown. Here by analysis of QFL T cells, a population of CD8+ T cells critical
Externí odkaz:
https://doaj.org/article/54430899bea94fd7b55a65b2c274a757
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionHLA-DO (DO) is an accessory protein that binds DM for trafficking to MIIC and has peptide editing functions. DO is mainly expressed in thymic medulla and B cells. Using biochemical experiments, our lab has discovered that DO has different
Externí odkaz:
https://doaj.org/article/8bcb31636e1d43089893cd81bea60a04
Autor:
Adrian Martín-Esteban, Jesus Contreras Rodriguez, David Peske, Jose A. Lopez de Castro, Nilabh Shastri, Scheherazade Sadegh-Nasseri
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionCritical steps in Major Histocompatibility Complex Class I (MHC-I) antigen presentation occur in the endoplasmic reticulum (ER). In general, peptides that enter the ER are longer than the optimal length for MHC-I binding. The final trimmi
Externí odkaz:
https://doaj.org/article/29cab1404e6c4ef6b3ee155117a2007e
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Dendritic cells are the antigen presenting cells that process antigens effectively and prime the immune system, a characteristic that have gained them the spotlights in recent years. B cell antigen presentation, although less prominent, deserves equa
Externí odkaz:
https://doaj.org/article/692891a3f4894614991b615e057caa72
Autor:
Robin A Welsh, Nianbin Song, Catherine A Foss, Tatiana Boronina, Robert N Cole, Scheherazade Sadegh-Nasseri
Publikováno v:
PLoS Biology, Vol 18, Iss 2, p e3000590 (2020)
DO (HLA-DO, in human; murine H2-O) is a highly conserved nonclassical major histocompatibility complex class II (MHC II) accessory molecule mainly expressed in the thymic medulla and B cells. Previous reports have suggested possible links between DO
Externí odkaz:
https://doaj.org/article/e5e4c2e645ad4590ad5a34c09d623322
Autor:
Scheherazade Sadegh-Nasseri
Publikováno v:
F1000Research, Vol 5 (2016)
T cell antigen receptors (TCRs) expressed on cytotoxic or helper T cells can only see their specific target antigen as short sequences of peptides bound to the groove of proteins of major histocompatibility complex (MHC) class I, and class II respect
Externí odkaz:
https://doaj.org/article/56ada896c1934634a83f9bab7b2cca19
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71228 (2013)
Processing of antigens for presentation to helper T cells by MHC class II involves HLA-DM (DM) and HLA-DO (DO) accessory molecules. A mechanistic understanding of DO in this process has been missing. The leading model on its function proposes that DO
Externí odkaz:
https://doaj.org/article/62e1eb3d33a5454aa8e4d844c7ccdc11
Autor:
Kedar Narayan, Edward M Perkins, Gavin E Murphy, Sarat K Dalai, Michael Edidin, Sriram Subramaniam, Scheherazade Sadegh-Nasseri
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6188 (2009)
The superantigen SEA causes non-specific hyperactivation of T and B cells at low concentrations. Studies of mutants or soluble proteins suggest SEA is bivalent for its ligand, MHC class II. However, the interaction between these molecules on intact c
Externí odkaz:
https://doaj.org/article/9e3067f0364440ef921948f6ea68e856