Výsledky vyhledávání - "Scheffer, Gl"

The role of breast cancer resistance protein in acute lymphoblastic leukemia

Autor: Plasschaert, SLA, van der Kolk, D.M., de Bout, ESJM, Kamps, WA, Morisaki, K, Bates, SE, Scheffer, GL, Scheper, RJ, Vellenga, E, de Vries, EGE

Publikováno v: Clinical Cancer Research, 9(14), 5171-5177. AMER ASSOC CANCER RESEARCH

Purpose: Overexpression of the transporter ABCG2, also known as breast cancer resistance protein and mitoxantrone resistance protein, can confer resistance to a variety of cytostatic drugs, such as mitoxantrone, topotecan, doxorubicin, and daunorubic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::dc4289dda4c3bac70a442243f53c4cb4
https://research.rug.nl/en/publications/2ecdf1a4-7591-4012-8b9b-46a99c4682b1

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Expression and activity of breast cancer resistance protein (BCRP) in de novo and relapsed acute myeloid leukemia

Autor: Vellenga, E, Scheffer, GL, Muller, M, Bates, SE, Scheper, RJ, de Vries, EGE

Publikováno v: Blood, 99(10), 715A-716A. AMER SOC HEMATOLOGY

Overexpression of the breast cancer resistance protein (BCRP) efflux pump In human cancer cell lines results in resistance to a variety of cytostatic agents. The aim of this study was to analyze BCRP protein expression and activity In acute myeloid l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::7520aae3a6b775ffafaa12390127e96d
https://research.rug.nl/en/publications/72f28bc1-e530-4833-b8b8-dbeeb5ba363b

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The wide spectrum of multidrug resistance 3 deficiency: From neonatal cholestasis to cirrhosis of adulthood

Autor: Jacquemin, E, de Vree, JML, Cresteil, D, Sokal, EM, Sturm, E, Dumont, M, Scheffer, GL, Paul, M, Burdelski, M, Bernard, O, Hadchouel, M, Elferink, RPJO

Publikováno v: Gastroenterology, 120(6), 1448-1458. W B SAUNDERS CO-ELSEVIER INC

Background & Aims: We have specified the features of progressive familial intrahepatic cholestasis type 3 and investigated in 31 patients whether a defect of the multidrug resistance 3 gene (MDR3) underlies this phenotype. Methods: MDR3 sequencing li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::d5808b7b5919a55c747836ae56454574
https://research.rug.nl/en/publications/7d555be3-8fe1-4d12-81d6-f415089dd702

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Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines

Autor: Scheffer, GL, Maliepaard, M, Pijnenborg, ACLM, van Gastelen, MA, Schroeijers, AB, Allen, JD, Ross, DD, van der Valk, P, Dalton, WS, Schellens, JHM, Scheper, RJ, de Jong, MC

Publikováno v: Cancer Research, 60(10), 2589-2593. AMER ASSOC CANCER RESEARCH

Tumor cells may display a multidrug resistant phenotype by overexpression of ATP-binding cassette transporters such as multidrug resistance (,MDR1) P-glycoprotein, multidrug resistance protein 1 (MRP1), and breast cancer resistance protein (BCRP). Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::17cdff6af0e54ebe9f2bf0aabeb27aa7
https://research.rug.nl/en/publications/81f62d59-dab8-44e5-88cf-72886c290ce9

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Transport of topoisomerase I inhibitors by the breast cancer resistance protein - Potential clinical implications

Autor: Schellens, JHM, Maliepaard, M, Scheper, RJ, Scheffer, GL, Jonker, JW, Smit, JW, Beijnen, JH, Schinkel, AH, Liehr, JG, Giovanella, BC, Verschaegen, CF

Publikováno v: CAMPTOTHECINS: UNFOLDING THEIR ANTICANER POTENTIAL, 188-194
STARTPAGE=188;ENDPAGE=194;TITLE=CAMPTOTHECINS: UNFOLDING THEIR ANTICANER POTENTIAL

The multidrug resistance protein BCRP (breast cancer resistance protein) is a member of the ATP-binding cassette family of drug transporters. Overexpression of BCRP caused by exposure of cells to mitoxantrone (MX) or doxorubicin/verapamil resulted in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::1b4ed4338f0de0d57919a0a6572b0d1c
https://research.rug.nl/en/publications/92a03833-7106-4db5-81f0-cb3a25760aa8

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THE LRP GENE ENCODING A MAJOR VAULT PROTEIN ASSOCIATED WITH DRUG-RESISTANCE MAPS PROXIMAL TO MRP ON CHROMOSOME-16 - EVIDENCE THAT CHROMOSOME BREAKAGE PLAYS A KEY ROLE IN MRP OR LRP GENE AMPLIFICATION

Autor: SLOVAK, ML, HO, JP, COLE, SPC, DEELEY, RG, GREENBERGER, L, DEVRIES, EGE, BROXTERMAN, HJ, SCHEFFER, GL, SCHEPER, RJ

Publikováno v: Cancer Research, 55(19), 4214-4219. AMER ASSOC CANCER RESEARCH

A cDNA encoding the novel drug resistance gene, LRP (originally termed lung resistance-related protein), was isolated from HT1080/DR4, a 220-fold doxorubicin-resistant human fibrosarcoma cell line which displays a multidrug resistance phenotype and o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::d17c9862590881d9a8afab1c057a7697
https://research.rug.nl/en/publications/01423065-ccbb-4c54-9ef5-134970ab91d2

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DRUG RESISTANCE-ASSOCIATED MARKER LRP FOR PREDICTION OF RESPONSE TO CHEMOTHERAPY AND PROGNOSES IN ADVANCED OVARIAN-CARCINOMA

Autor: IZQUIERDO, MA, VANDERZEE, AGJ, VERMORKEN, JB, VANDERVALK, P, BELIEN, JAM, GIACCONE, G, SCHEFFER, GL, FLENS, MJ, PINEDO, HM, KENEMANS, P, MEIJER, CJLM, DEVRIES, EGE, SCHEPER, RJ

Publikováno v: JOURNAL OF THE NATIONAL CANCER INSTITUTE, 87(16), 1230-1237. Oxford University Press

Background: Drug resistance is a major impediment to the successful treatment of ovarian carcinoma. None of the earlier-identified resistance mechanisms, such as overexpression of the MDR1 gene product, P-glycoprotein (Pgp), has been shown to be a ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::54d031a51c43214b8319012c4997f3ee
https://research.rug.nl/en/publications/0318caf6-3c66-4b55-af47-2872f52706ce

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