Global Study on the Accuracy of Human Epidermal Growth Factor Receptor 2-Low Diagnosis in Breast Cancer.

Autor: Rüschoff J; From the Discovery Life Sciences Biomarker Services GmbH, Kassel, Germany (Rüschoff, Penner, Baenfer, Schildhaus)., Penner A; From the Discovery Life Sciences Biomarker Services GmbH, Kassel, Germany (Rüschoff, Penner, Baenfer, Schildhaus)., Ellis IO; Translational Medical Sciences, School of Medicine, The University of Nottingham, Department of Histopathology, City Hospital Campus, Nottingham University Hospitals, Nottingham, United Kingdom (Ellis)., Hammond MEH; Department of Pathology, Intermountain Healthcare and University of Utah School of Medicine, Salt Lake City (Hammond)., Lebeau A; University Medical Center Hamburg-Eppendorf, Institute of Pathology, Hamburg, Germany (Lebeau).; Private Group Practice for Pathology, Lübeck, Germany (Lebeau)., Osamura RY; Department of Diagnostic Pathology, Nippon Koukan Hospital, Kawasaki, Japan (Osamura)., Penault-Llorca F; Centre Jean Perrin, Université Clermont Auvergne, INSERM, U1240 Imagerie Moléculaire et Stratégies Théranostiques, Clermont Ferrand, France (Penault-Llorca)., Rojo F; Department of Pathology, IIS-Hospital Universitario Fundacion Jimenez Diaz-CIBERONC, Madrid, Spain (Rojo)., Desai C; Daiichi Sankyo, Basking Ridge, New Jersey (Desai, Moh)., Moh A; Daiichi Sankyo, Basking Ridge, New Jersey (Desai, Moh)., Atkey N; Diaceutics plc, Dataworks at Kings Hall Life Sciences Park, Belfast, County Antrim, United Kingdom (Atkey)., Baenfer G; From the Discovery Life Sciences Biomarker Services GmbH, Kassel, Germany (Rüschoff, Penner, Baenfer, Schildhaus)., Scheel AH; Department of Pathology, University of Cologne, Cologne, Germany (Scheel)., D'Arrigo C; Poundbury Cancer Institute, Dorchester, United Kingdom (D'Arrigo)., Schildhaus HU; From the Discovery Life Sciences Biomarker Services GmbH, Kassel, Germany (Rüschoff, Penner, Baenfer, Schildhaus)., Viale G; Department of Pathology, IEO European Institute of Oncology IRCCS Milan, Italy (Viale).

Publikováno v: Archives of pathology & laboratory medicine [Arch Pathol Lab Med] 2024 Aug 08. Date of Electronic Publication: 2024 Aug 08.

Evolutionary trajectories of small cell lung cancer under therapy.

Autor: George J; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. jgeorge@uni-koeln.de.; Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine and University Hospital Cologne, University Hospital of Cologne, Cologne, Germany. jgeorge@uni-koeln.de., Maas L; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Abedpour N; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University Hospital Cologne, Cologne, Germany.; Cancer Research Centre Cologne Essen, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Cartolano M; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Centre for Molecular Medicine, University of Cologne, Cologne, Germany., Kaiser L; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Fischer RN; Department I of Internal Medicine, Lung Cancer Group Cologne, University Hospital Cologne, Cologne, Germany., Scheel AH; Institute of Pathology, Medical Faculty, University Hospital Cologne, University of Cologne, Cologne, Germany., Weber JP; Department I of Internal Medicine, Lung Cancer Group Cologne, University Hospital Cologne, Cologne, Germany., Hellmich M; Institute of Medical Statistics, and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Bosco G; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Volz C; Department I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University Hospital Cologne, Cologne, Germany.; Centre for Molecular Medicine, University of Cologne, Cologne, Germany., Mueller C; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine and University Hospital Cologne, University Hospital of Cologne, Cologne, Germany., Dahmen I; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., John F; Department I of Internal Medicine, Lung Cancer Group Cologne, University Hospital Cologne, Cologne, Germany., Alves CP; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Werr L; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Panse JP; Department of Haematology, Oncology, Haemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany.; Centre for Integrated Oncology, Aachen Bonn Cologne Düsseldorf, Aachen, Germany., Kirschner M; Department of Haematology, Oncology, Haemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany.; Centre for Integrated Oncology, Aachen Bonn Cologne Düsseldorf, Aachen, Germany., Engel-Riedel W; Department of Pneumology, City of Cologne Municipal Hospitals, Lung Hospital Cologne Merheim, Cologne, Germany., Jürgens J; Department of Pneumology, City of Cologne Municipal Hospitals, Lung Hospital Cologne Merheim, Cologne, Germany., Stoelben E; Thoraxclinic Cologne, Thoracic Surgery, St. Hildegardis-Krankenhaus, Cologne, Germany., Brockmann M; Department of Pathology, City of Cologne Municipal Hospitals, Witten/Herdecke University, Cologne, Germany., Grau S; Department of General Neurosurgery, Centre of Neurosurgery, University Hospital Cologne, Cologne, Germany.; University Medicine Marburg - Campus Fulda, Department of Neurosurgery, Fulda, Germany., Sebastian M; Department of Medicine II, Haematology/Oncology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt, Germany.; DKFZ, German Cancer Research Centre, German Cancer Consortium, Heidelberg, Germany., Stratmann JA; Department of Medicine II, Haematology/Oncology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt, Germany., Kern J; Klinikum Würzburg Mitte - Missioklinik site, Pneumology and Respiratory Medicine, Würzburg, Germany., Hummel HD; Translational Oncology/Early Clinical Trial Unit, Comprehensive Cancer Centre Mainfranken, University Hospital Wuerzburg, Wuerzburg, Germany., Hegedüs B; Department of Thoracic Surgery, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Essen, Germany., Schuler M; DKFZ, German Cancer Research Centre, German Cancer Consortium, Heidelberg, Germany.; Department of Medical Oncology, West German Cancer Centre Essen, University Duisburg-Essen, Essen, Germany., Plönes T; Department of Medical Oncology, West German Cancer Centre Essen, University Duisburg-Essen, Essen, Germany.; Division of Thoracic Surgery, Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany., Aigner C; Department of Thoracic Surgery, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Essen, Germany.; Department of Thoracic Surgery, Medical University of Vienna, Vienna General Hospital, Vienna, Austria., Elter T; Department I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University Hospital Cologne, Cologne, Germany., Toepelt K; Department I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University Hospital Cologne, Cologne, Germany., Ko YD; Comprehensive Cancer Centre CIO Bonn, Bonn, Germany., Kurz S; Department of Respiratory Diseases, Evangelische Lungenklinik, Berlin, Germany., Grohé C; Department of Respiratory Diseases, Evangelische Lungenklinik, Berlin, Germany., Serke M; DGD Lungenklinik Hemer, Internal Medicine, Pneumology and Oncology, Hemer, Germany., Höpker K; Clinic III for Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Hagmeyer L; Clinic of Pneumology and Allergology, Centre for Sleep Medicine and Respiratory Care, Bethanien Hospital Solingen, Solingen, Germany., Doerr F; Department of Thoracic Surgery, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Essen, Germany.; Department of Cardiothoracic Surgery, University Hospital of Cologne, Cologne, Germany., Hekmath K; Department of Cardiothoracic Surgery, University Hospital of Cologne, Cologne, Germany., Strapatsas J; Department of Haematology, Oncology and Clinical Immunology, University Hospital of Duesseldorf, Düsseldorf, Germany., Kambartel KO; Krankenhaus Bethanien Moers, Moers, Germany., Chakupurakal G; Praxis für Hämatologie und Onkologie, Koblenz, Germany., Busch A; Medical Clinic III for Oncology, Haematology, Immune-Oncology and Rheumatology, Centre for Integrative Medicine, University Hospital Bonn, Bonn, Germany., Bauernfeind FG; Medical Clinic III for Oncology, Haematology, Immune-Oncology and Rheumatology, Centre for Integrative Medicine, University Hospital Bonn, Bonn, Germany., Griesinger F; Pius-Hospital Oldenburg, Department of Haematology and Oncology, University Department Internal Medicine-Oncology, University Medicine Oldenburg, Oldenburg, Germany., Luers A; Pius-Hospital Oldenburg, Department of Haematology and Oncology, University Department Internal Medicine-Oncology, University Medicine Oldenburg, Oldenburg, Germany., Dirks W; Pius-Hospital Oldenburg, Department of Haematology and Oncology, University Department Internal Medicine-Oncology, University Medicine Oldenburg, Oldenburg, Germany., Wiewrodt R; Pulmonary Division, Department of Medicine A, Münster University Hospital, Münster, Germany., Luecke A; Pulmonary Division, Department of Medicine A, Münster University Hospital, Münster, Germany., Rodermann E; Onkologie Rheinsieg, Praxisnetzwerk Hämatologie und Internistische Onkologie, Troisdorf, Germany., Diel A; Onkologie Rheinsieg, Praxisnetzwerk Hämatologie und Internistische Onkologie, Troisdorf, Germany., Hagen V; Clinic II for Internal Medicine, St.-Johannes-Hospital Dortmund, Dortmund, Germany., Severin K; Haematologie und Onkologie Köln MV-Zentrum, Cologne, Germany., Ullrich RT; Department I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University Hospital Cologne, Cologne, Germany.; Centre for Molecular Medicine, University of Cologne, Cologne, Germany., Reinhardt HC; Department of Haematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany.; West German Cancer Centre, University Hospital Essen, Essen, Germany., Quaas A; Institute of Pathology, Medical Faculty, University Hospital Cologne, University of Cologne, Cologne, Germany., Bogus M; Institute of Legal Medicine, University of Cologne, Cologne, Germany., Courts C; Institute of Legal Medicine, University of Cologne, Cologne, Germany., Nürnberg P; Cologne Centre for Genomics, West German Genome Centre, University of Cologne, Cologne, Germany., Becker K; Cologne Centre for Genomics, West German Genome Centre, University of Cologne, Cologne, Germany., Achter V; Computing Centre, University of Cologne, Cologne, Germany., Büttner R; Institute of Pathology, Medical Faculty, University Hospital Cologne, University of Cologne, Cologne, Germany., Wolf J; Department I of Internal Medicine, Lung Cancer Group Cologne, University Hospital Cologne, Cologne, Germany., Peifer M; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. mpeifer@uni-koeln.de.; Centre for Molecular Medicine, University of Cologne, Cologne, Germany. mpeifer@uni-koeln.de., Thomas RK; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. roman.thomas@uni-koeln.de.; Institute of Pathology, Medical Faculty, University Hospital Cologne, University of Cologne, Cologne, Germany. roman.thomas@uni-koeln.de.; DKFZ, German Cancer Research Centre, German Cancer Consortium, Heidelberg, Germany. roman.thomas@uni-koeln.de.

Publikováno v: Nature [Nature] 2024 Mar; Vol. 627 (8005), pp. 880-889. Date of Electronic Publication: 2024 Mar 13.

KEAP1/NFE2L2 Pathway Signature Outperforms KEAP1/NFE2L2 Mutation Status and Reveals Alternative Pathway-Activating Mutations in NSCLC.

Autor: Arolt C; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Dugan M; Dracen Pharmaceuticals Inc., San Diego, California., Wild R; Dracen Pharmaceuticals Inc., San Diego, California., Richartz V; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Holz B; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Scheel AH; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Brägelmann J; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany; Department of Translational Genomics, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany; Mildred Scheel School of Oncology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Wagener-Ryczek S; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Merkelbach-Bruse S; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany; Lung Cancer Group Cologne, Center for Integrated Oncology Cologne/Bonn, University Hospital Cologne, Cologne, Germany., Wolf J; Lung Cancer Group Cologne, Center for Integrated Oncology Cologne/Bonn, University Hospital Cologne, Cologne, Germany; Department I for Internal Medicine, Center for Integrated Oncology Cologne/Bonn, University Hospital Cologne, Cologne, Germany., Buettner R; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany; Lung Cancer Group Cologne, Center for Integrated Oncology Cologne/Bonn, University Hospital Cologne, Cologne, Germany., Catanzariti L; Dracen Pharmaceuticals Inc., San Diego, California., Scheffler M; Lung Cancer Group Cologne, Center for Integrated Oncology Cologne/Bonn, University Hospital Cologne, Cologne, Germany; Department I for Internal Medicine, Center for Integrated Oncology Cologne/Bonn, University Hospital Cologne, Cologne, Germany., Hillmer AM; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany. Electronic address: ahillmer@uni-koeln.de.

Publikováno v: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2023 Nov; Vol. 18 (11), pp. 1550-1567. Date of Electronic Publication: 2023 Jul 18.

Tumour area infiltration and cell count in endoscopic biopsies of therapy-naive upper GI tract carcinomas by QuPath analysis: implications for predictive biomarker testing.

Autor: Scheel AH; Institute of Pathology, University Hospital Cologne, Medical Faculty, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Lamberty H; Institute of Pathology, University Hospital Cologne, Medical Faculty, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Tolkach Y; Institute of Pathology, University Hospital Cologne, Medical Faculty, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Gebauer F; Department of General, Visceral and Cancer Surgery, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, Germany., Schoemig-Markiefka B; Institute of Pathology, University Hospital Cologne, Medical Faculty, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Zander T; Department of Internal Medicine I, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, Germany., Buettner R; Institute of Pathology, University Hospital Cologne, Medical Faculty, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Rueschoff J; Targos Molecular Pathology GmbH, Kassel, Germany., Bruns CJ; Department of General, Visceral and Cancer Surgery, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, Germany., Schroeder W; Department of General, Visceral and Cancer Surgery, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, Germany., Quaas A; Institute of Pathology, University Hospital Cologne, Medical Faculty, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. alexander.quaas@uk-koeln.de.

Publikováno v: Scientific reports [Sci Rep] 2023 Oct 16; Vol. 13 (1), pp. 17580. Date of Electronic Publication: 2023 Oct 16.

Rebiopsy in advanced non-small cell lung cancer, clinical relevance and prognostic implications.

Autor: Scheffler M; Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Lung Cancer Group Cologne, University of Cologne, Germany., Wiesweg M; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Germany; Division of Thoracic Oncology, West German Cancer Center, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Germany., Michels S; Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Lung Cancer Group Cologne, University of Cologne, Germany., Nogová L; Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Lung Cancer Group Cologne, University of Cologne, Germany., Kron A; Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Lung Cancer Group Cologne, University of Cologne, Germany., Herold T; Institute of Pathology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Germany., Scheel AH; Faculty of Medicine and University Hospital Cologne, Institute of Pathology, University of Cologne, Germany., Metzenmacher M; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Germany; Division of Thoracic Oncology, West German Cancer Center, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Germany., Eberhardt WE; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Germany; Division of Thoracic Oncology, West German Cancer Center, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Germany., Reis H; Institute of Pathology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Germany., Fassunke J; Faculty of Medicine and University Hospital Cologne, Institute of Pathology, University of Cologne, Germany., Darwiche K; Department of Pulmonary Medicine, Section of Interventional Pneumology, West German Cancer Center, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Germany., Aigner C; Department of Thoracic Surgery and Endoscopy, West German Cancer Center, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Germany., Schaufler D; Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Lung Cancer Group Cologne, University of Cologne, Germany., Riedel R; Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Lung Cancer Group Cologne, University of Cologne, Germany., Fischer R; Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Lung Cancer Group Cologne, University of Cologne, Germany., Koleczko S; Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Lung Cancer Group Cologne, University of Cologne, Germany., Schildhaus HU; Institute of Pathology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Germany., Merkelbach-Bruse S; Faculty of Medicine and University Hospital Cologne, Institute of Pathology, University of Cologne, Germany., Schmid KW; Institute of Pathology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Germany., Büttner R; Faculty of Medicine and University Hospital Cologne, Institute of Pathology, University of Cologne, Germany., Wolf J; Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Lung Cancer Group Cologne, University of Cologne, Germany., Schuler M; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Germany; Division of Thoracic Oncology, West German Cancer Center, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Germany; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Germany. Electronic address: martin.schuler@uk-essen.de.

Publikováno v: Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2022 Jun; Vol. 168, pp. 10-20. Date of Electronic Publication: 2022 Apr 16.