Pivotal roles for cancer cell-intrinsic mPGES-1 and autocrine EP4 signaling in suppressing antitumor immunity.

Autor: Markosyan N; Abramson Cancer Center, Perelman School of Medicine.; Abramson Family Cancer Research Institute, Department of Medicine, and., Kim IK; Abramson Cancer Center, Perelman School of Medicine.; Abramson Family Cancer Research Institute, Department of Medicine, and., Arora C; Abramson Cancer Center, Perelman School of Medicine., Quinones-Ware L; Abramson Cancer Center, Perelman School of Medicine., Joshi N; Abramson Cancer Center, Perelman School of Medicine., Cheng N; Abramson Cancer Center, Perelman School of Medicine., Schechter EY; Abramson Cancer Center, Perelman School of Medicine., Tobias JW; Penn Genomics and Sequencing Core, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Hochberg JE; Abramson Cancer Center, Perelman School of Medicine., Corse E; Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA., Liu K; Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA., Rodriguez DiBlasi V; Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA., Chan LE; Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA., Smyth EM; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA., FitzGerald GA; Department of Medicine.; Institute of Translational Medicine and Therapeutics, and., Stanger BZ; Abramson Cancer Center, Perelman School of Medicine.; Abramson Family Cancer Research Institute, Department of Medicine, and., Vonderheide RH; Abramson Cancer Center, Perelman School of Medicine.; Abramson Family Cancer Research Institute, Department of Medicine, and.; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Publikováno v: JCI insight [JCI Insight] 2024 Nov 08; Vol. 9 (21). Date of Electronic Publication: 2024 Nov 08.