RAG1/2 induces double-stranded DNA breaks at non-Ig loci in the proximity of single sequence repeats in developing B cells.

Autor: Ochodnicka-Mackovicova K; Department of Pathology, Amsterdam University Medical Center, Location AMC, University of Amsterdam, Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Amsterdam, The Netherlands., Mokry M; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Haagmans M; Core Facility Genomics, Department of Clinical Genetics, Amsterdam University Medical Center, The Netherlands., Bradley TE; Core Facility Genomics, Department of Clinical Genetics, Amsterdam University Medical Center, The Netherlands., van Noesel CJM; Department of Pathology, Amsterdam University Medical Center, Location AMC, University of Amsterdam, Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Amsterdam, The Netherlands., Guikema JEJ; Department of Pathology, Amsterdam University Medical Center, Location AMC, University of Amsterdam, Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Amsterdam, The Netherlands.

Publikováno v: European journal of immunology [Eur J Immunol] 2024 Oct; Vol. 54 (10), pp. e2350958. Date of Electronic Publication: 2024 Jul 24.

T‐cell receptor repertoire analysis of CD4‐positive T cells from blood and an affected organ in an autoimmune mouse model.

Autor: Ishikawa, Tatsuya^1,2 (AUTHOR), Horie, Kenta¹ (AUTHOR), Takakura, Yuki¹ (AUTHOR), Ohki, Houko^1,2 (AUTHOR), Maruyama, Yuya^1,2 (AUTHOR), Hayama, Mio^1,2 (AUTHOR), Miyauchi, Maki^1,2 (AUTHOR), Miyao, Takahisa^1,2 (AUTHOR), Hagiwara, Naho¹ (AUTHOR), Kobayashi, Tetsuya J.³ (AUTHOR), Akiyama, Nobuko^1,2 (AUTHOR) nobuko.akiyama@riken.jp, Akiyama, Taishin^1,2 (AUTHOR) taishin.akiyama@riken.jp

Publikováno v: Genes to Cells. Dec2023, Vol. 28 Issue 12, p929-941. 13p.

Intermolecular V(D)J recombination.

Autor: Tevelev, A, Schatz, D G

Publikováno v: Journal of Biological Chemistry; March 2000, Vol. 275 Issue: 12 p8341-8, 8p

A dimer of the lymphoid protein RAG1 recognizes the recombination signal sequence and the complex stably incorporates the high mobility group protein HMG2.

Autor: Rodgers, K K, Villey, I J, Ptaszek, L, Corbett, E, Schatz, D G, Coleman, J E

Publikováno v: Nucleic Acids Research; July 1999, Vol. 27 Issue: 14 p2938-2946, 9p

A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice.

Autor: Shockett, P, Difilippantonio, M, Hellman, N, Schatz, D G

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; July 1995, Vol. 92 Issue: 14 p6522-6526, 5p