IL-1β disrupts the initiation of blood-brain barrier development by inhibiting endothelial Wnt/β-catenin signaling

Autor: Audrey R. Fetsko, Dylan J. Sebo, Lilyana B. Budzynski, Alli Scharbarth, Michael R. Taylor

Publikováno v: iScience, Vol 27, Iss 5, Pp 109651- (2024)

Summary: During neuroinflammation, the proinflammatory cytokine interleukin-1β (IL-1β) impacts blood-brain barrier (BBB) function by disrupting brain endothelial tight junctions, promoting vascular permeability, and increasing transmigration of imm

Externí odkaz: https://doaj.org/article/f374988a53c64b65aff976fc5cedfbe9

IL-1β disrupts blood-brain barrier development by inhibiting endothelial Wnt/β-catenin signaling.

Autor: Fetsko AR; School of Pharmacy, Division of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, WI, USA., Sebo DJ; School of Pharmacy, Division of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, WI, USA., Budzynski LB; School of Pharmacy, Pharmacology and Toxicology Program, University of Wisconsin-Madison, Madison, WI, USA., Scharbarth A; School of Pharmacy, Pharmacology and Toxicology Program, University of Wisconsin-Madison, Madison, WI, USA., Taylor MR; School of Pharmacy, Division of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, WI, USA.; School of Pharmacy, Pharmacology and Toxicology Program, University of Wisconsin-Madison, Madison, WI, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 07. Date of Electronic Publication: 2024 Feb 07.