An integrated encyclopedia of DNA elements in the human genome

Autor: Robert Altshuler, Laura Elnitski, Michael Anaya, Alec Victorsen, Deborah Winter, Javier Herrero, Katherine Varley, Andrea Sboner, Oscar Junhong Luo, Marco Mariotti, Cristina Sisu, Mike Kay, Timothy Dreszer, Jane Loveland, Alexandra Bignell, Ewan Birney, Tim @timjph Hubbard, Kuljeet Sandhu, Eric Haugen, Chris Gunter, Alexej Abyzov, Lucas Ward, Georgi Marinov, Michael Pazin, Thomas Gingeras, Alexander Dobin, Kimberly Foss, Xianjun Dong, Benoit Miotto, Piotr Mieczkowski, Cedric Notredame, Andrew Berry, Shawn Gillespie, Axel Visel, Shawn Levy, Richard Sandstrom, Jose M Gonzalez, Melissa Fullwood, Timo Lassmann, Michael Tress, Julien Lagarde, Kevin Yip, Leslie Adams, Sylvain Foissac, Bronwen Aken, Piero Carninci, Suganthi Balasubramanian, Andrea Tanzer, Sarah Djebali, Michael Hoffman, Gloria Despacio-Reyes, Peter Park, Felix Kokocinski, Katherine Fisher-Aylor, Juan M Vaquerizas, Peggy Farnham, Patrick Collins, Amonida Zadissa, Pedro Ferreira, Philippe Batut, Michael Snyder, Electra Tapanari, Adam Frankish, Paul Flicek, AMARTYA SANYAL, Tyler Alioto, Giovanni Bussotti, Laurence Meyer, Jingyi Jessica Li, Matthew Blow, Tristan FRUM, Roger Alexander, Rory Johnson, Charles Steward, Meizhen Zheng, Margus Lukk, Ross Hardison, Claire Davidson, Gary Saunders, Alan Boyle, Luiz Penalva, Rajinder Kaul, Lazaro Centanin, Florencia Pauli Behn, Thomas Derrien, Nathan Sheffield, Toby Hunt, Eric Nguyen, Jeff Vierstra, Konrad Karczewski, Kimberly Bell, Yanbao Yu, Hagen U Tilgner, James Taylor, Balázs Bánfai, Catherine Snow, Benjamin Vernot, Stephan Kirchmaier, Michael Sammeth, Steven Wilder, Angelika Merkel, Joanna Mieczkowska, Guoliang Li, Wei Lin, Jennifer Harrow, Thomas Oliver Auer, Daniel Barrell, Eddie Park, Alvis Brazma, Hazuki Takahashi, Nathan Johnson, Daniel Sobral, Terry Furey, Alexandre Reymond, Jonathan Mudge, Anshul Kundaje, Jose Rodriguez, Akshay Bhinge, James Gilbert, Jakub Karczewski, Venkat Malladi, Troy Whitfield, Orion Buske, Ian Dunham, Jennifer Moran, Joachim Wittbrodt, Charles B. Epstein, Laurens Wilming, Jason Gertz, Joshua Akey, Joel Rozowsky

Publikováno v: Nature
Nature, Nature Publishing Group, 2012, 489 (7414), pp.57-74. ⟨10.1038/nature11247⟩
NATURE
Nature, Vol. 489, No 7414 (2012) pp. 57-74
PMC
Recercat. Dipósit de la Recerca de Catalunya
instname

The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of transcription, transcription fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b208801384684d0028cc28316677b0d
https://hal.archives-ouvertes.fr/hal-01217624

Post-operative Crohn's Disease Recurrence and Infectious Complications: A Transcriptomic Analysis.

Autor: Chen KA; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Bioinformatics Building; CB #7555, 130 Mason Farm Road, Chapel Hill, NC, 27599, USA.; Department of Surgery, University of North Carolina at Chapel Hill, 100 Manning Drive, Burnett Womack Building, Suite 4038, Chapel Hill, NC, 27599, USA., Gartner V; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Bioinformatics Building; CB #7555, 130 Mason Farm Road, Chapel Hill, NC, 27599, USA., Darlington KC; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Bioinformatics Building; CB #7555, 130 Mason Farm Road, Chapel Hill, NC, 27599, USA., Silverstein SR; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Bioinformatics Building; CB #7555, 130 Mason Farm Road, Chapel Hill, NC, 27599, USA., Kennedy Ng MM; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Bioinformatics Building; CB #7555, 130 Mason Farm Road, Chapel Hill, NC, 27599, USA., Butler L; Department of Surgery, University of North Carolina at Chapel Hill, 100 Manning Drive, Burnett Womack Building, Suite 4038, Chapel Hill, NC, 27599, USA., Avalos K; Department of Surgery, University of North Carolina at Chapel Hill, 100 Manning Drive, Burnett Womack Building, Suite 4038, Chapel Hill, NC, 27599, USA., Nishiyama NC; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Bioinformatics Building; CB #7555, 130 Mason Farm Road, Chapel Hill, NC, 27599, USA., Joisa CU; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, 10202C Mary Ellen Jones Building, Chapel Hill, NC, 27599, USA., Schaner MR; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Bioinformatics Building; CB #7555, 130 Mason Farm Road, Chapel Hill, NC, 27599, USA., Lian G; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Bioinformatics Building; CB #7555, 130 Mason Farm Road, Chapel Hill, NC, 27599, USA., Beasley C; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Bioinformatics Building; CB #7555, 130 Mason Farm Road, Chapel Hill, NC, 27599, USA., Lau GW; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Bioinformatics Building; CB #7555, 130 Mason Farm Road, Chapel Hill, NC, 27599, USA., Bauer MJ; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Bioinformatics Building; CB #7555, 130 Mason Farm Road, Chapel Hill, NC, 27599, USA., Zhu LC; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, CB #7525, Brinkhous-Bullitt Building, Chapel Hill, NC, 27599, USA., Kapadia MR; Department of Surgery, University of North Carolina at Chapel Hill, 100 Manning Drive, Burnett Womack Building, Suite 4038, Chapel Hill, NC, 27599, USA., Gomez SM; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, 10202C Mary Ellen Jones Building, Chapel Hill, NC, 27599, USA., Furey TS; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Bioinformatics Building; CB #7555, 130 Mason Farm Road, Chapel Hill, NC, 27599, USA. tsfurey@email.unc.edu.; Department of Genetics, Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, 5000D Genetic Medicine Building, 120 Mason Farm Road, Chapel Hill, NC, CB #726427599, USA. tsfurey@email.unc.edu., Sheikh SZ; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Bioinformatics Building; CB #7555, 130 Mason Farm Road, Chapel Hill, NC, 27599, USA.; University of North Carolina at Chapel Hill, 7314 Medical Biomolecular Research Building, 111 Mason Farm Road, Chapel Hill, NC, 27599, USA.

Publikováno v: Digestive diseases and sciences [Dig Dis Sci] 2024 Aug 31. Date of Electronic Publication: 2024 Aug 31.

Linking gene expression to clinical outcomes in pediatric Crohn's disease using machine learning.

Autor: Chen KA; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, 7314 Medical Biomolecular Research Building, 111 Mason Farm Road, Chapel Hill, NC, 27599, USA.; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, USA., Nishiyama NC; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, 7314 Medical Biomolecular Research Building, 111 Mason Farm Road, Chapel Hill, NC, 27599, USA.; Departments of Genetics and Biology, Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, 5022 Genetic Medicine Building, 120 Mason Farm Road, Chapel Hill, NC, 27599, USA., Kennedy Ng MM; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, 7314 Medical Biomolecular Research Building, 111 Mason Farm Road, Chapel Hill, NC, 27599, USA.; Departments of Genetics and Biology, Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, 5022 Genetic Medicine Building, 120 Mason Farm Road, Chapel Hill, NC, 27599, USA., Shumway A; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, USA., Joisa CU; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, USA., Schaner MR; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, 7314 Medical Biomolecular Research Building, 111 Mason Farm Road, Chapel Hill, NC, 27599, USA., Lian G; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, 7314 Medical Biomolecular Research Building, 111 Mason Farm Road, Chapel Hill, NC, 27599, USA., Beasley C; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, 7314 Medical Biomolecular Research Building, 111 Mason Farm Road, Chapel Hill, NC, 27599, USA., Zhu LC; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, USA., Bantumilli S; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, USA., Kapadia MR; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, USA., Gomez SM; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, USA., Furey TS; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, 7314 Medical Biomolecular Research Building, 111 Mason Farm Road, Chapel Hill, NC, 27599, USA. tsfurey@email.unc.edu.; Departments of Genetics and Biology, Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, 5022 Genetic Medicine Building, 120 Mason Farm Road, Chapel Hill, NC, 27599, USA. tsfurey@email.unc.edu., Sheikh SZ; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, 7314 Medical Biomolecular Research Building, 111 Mason Farm Road, Chapel Hill, NC, 27599, USA. shehzad_sheikh@med.unc.edu.

Publikováno v: Scientific reports [Sci Rep] 2024 Feb 01; Vol. 14 (1), pp. 2667. Date of Electronic Publication: 2024 Feb 01.

Increased colonic expression of ACE2 associates with poor prognosis in Crohn's disease.

Autor: Toyonaga T; Center for Gastrointestinal Biology and Disease, University of North Carolina At Chapel Hill, 111 Mason Farm Road, 7312B MBRB, UNC Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Gastroenterology and Hepatology, The Jikei University School of Medicine, Tokyo, Japan., Araba KC; Department of Genetics, Curriculum in Bioinformatics and Computational Biology, University of North Carolina At Chapel Hill, Chapel Hill, NC, USA.; Marsico Lung Institute, University of North Carolina At Chapel Hill, Chapel Hill, NC, USA., Kennedy MM; Center for Gastrointestinal Biology and Disease, University of North Carolina At Chapel Hill, 111 Mason Farm Road, 7312B MBRB, UNC Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Genetics, Curriculum in Bioinformatics and Computational Biology, University of North Carolina At Chapel Hill, Chapel Hill, NC, USA., Keith BP; Center for Gastrointestinal Biology and Disease, University of North Carolina At Chapel Hill, 111 Mason Farm Road, 7312B MBRB, UNC Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Genetics, Curriculum in Bioinformatics and Computational Biology, University of North Carolina At Chapel Hill, Chapel Hill, NC, USA., Wolber EA; Center for Gastrointestinal Biology and Disease, University of North Carolina At Chapel Hill, 111 Mason Farm Road, 7312B MBRB, UNC Chapel Hill, Chapel Hill, NC, 27599, USA., Beasley C; Center for Gastrointestinal Biology and Disease, University of North Carolina At Chapel Hill, 111 Mason Farm Road, 7312B MBRB, UNC Chapel Hill, Chapel Hill, NC, 27599, USA., Steinbach EC; Center for Gastrointestinal Biology and Disease, University of North Carolina At Chapel Hill, 111 Mason Farm Road, 7312B MBRB, UNC Chapel Hill, Chapel Hill, NC, 27599, USA.; Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of North Carolina At Chapel Hill, Chapel Hill, NC, USA., Schaner MR; Center for Gastrointestinal Biology and Disease, University of North Carolina At Chapel Hill, 111 Mason Farm Road, 7312B MBRB, UNC Chapel Hill, Chapel Hill, NC, 27599, USA., Jain A; Center for Gastrointestinal Biology and Disease, University of North Carolina At Chapel Hill, 111 Mason Farm Road, 7312B MBRB, UNC Chapel Hill, Chapel Hill, NC, 27599, USA., Long MD; Center for Gastrointestinal Biology and Disease, University of North Carolina At Chapel Hill, 111 Mason Farm Road, 7312B MBRB, UNC Chapel Hill, Chapel Hill, NC, 27599, USA., Barnes EL; Center for Gastrointestinal Biology and Disease, University of North Carolina At Chapel Hill, 111 Mason Farm Road, 7312B MBRB, UNC Chapel Hill, Chapel Hill, NC, 27599, USA., Herfarth HH; Center for Gastrointestinal Biology and Disease, University of North Carolina At Chapel Hill, 111 Mason Farm Road, 7312B MBRB, UNC Chapel Hill, Chapel Hill, NC, 27599, USA., Isaacs KL; Center for Gastrointestinal Biology and Disease, University of North Carolina At Chapel Hill, 111 Mason Farm Road, 7312B MBRB, UNC Chapel Hill, Chapel Hill, NC, 27599, USA., Hansen JJ; Center for Gastrointestinal Biology and Disease, University of North Carolina At Chapel Hill, 111 Mason Farm Road, 7312B MBRB, UNC Chapel Hill, Chapel Hill, NC, 27599, USA., Kapadia MR; Department of Surgery, University of North Carolina At Chapel Hill, Chapel Hill, NC, USA., Guillem JG; Department of Surgery, University of North Carolina At Chapel Hill, Chapel Hill, NC, USA., Gulati AS; Center for Gastrointestinal Biology and Disease, University of North Carolina At Chapel Hill, 111 Mason Farm Road, 7312B MBRB, UNC Chapel Hill, Chapel Hill, NC, 27599, USA.; Division of Gastroenterology, Department of Pediatrics, University of North Carolina At Chapel Hill, Chapel Hill, NC, USA., Sethupathy P; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA., Furey TS; Center for Gastrointestinal Biology and Disease, University of North Carolina At Chapel Hill, 111 Mason Farm Road, 7312B MBRB, UNC Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Genetics, Curriculum in Bioinformatics and Computational Biology, University of North Carolina At Chapel Hill, Chapel Hill, NC, USA.; Department of Biology, University of North Carolina At Chapel Hill, Chapel Hill, NC, USA., Ehre C; Marsico Lung Institute, University of North Carolina At Chapel Hill, Chapel Hill, NC, USA., Sheikh SZ; Center for Gastrointestinal Biology and Disease, University of North Carolina At Chapel Hill, 111 Mason Farm Road, 7312B MBRB, UNC Chapel Hill, Chapel Hill, NC, 27599, USA. shehzad_sheikh@med.unc.edu.; Department of Genetics, Curriculum in Bioinformatics and Computational Biology, University of North Carolina At Chapel Hill, Chapel Hill, NC, USA. shehzad_sheikh@med.unc.edu.

Publikováno v: Scientific reports [Sci Rep] 2021 Jun 29; Vol. 11 (1), pp. 13533. Date of Electronic Publication: 2021 Jun 29.

Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients With Crohn's Disease.

Autor: Toyonaga T; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Steinbach EC; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Division of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Keith BP; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Genetics, Department of Biology, Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Barrow JB; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Schaner MR; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Wolber EA; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Beasley C; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Huling J; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Wang Y; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Allbritton NL; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Chaumont N; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Sadiq TS; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Koruda MJ; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Jain A; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Long MD; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Barnes EL; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Herfarth HH; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Isaacs KL; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Hansen JJ; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Shanahan MT; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York., Rahbar R; Department of Surgery, Rex Healthcare of Wakefield, North Carolina., Furey TS; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Genetics, Department of Biology, Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Sethupathy P; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York., Sheikh SZ; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address: shehzad_sheikh@med.unc.edu.

Publikováno v: Cellular and molecular gastroenterology and hepatology [Cell Mol Gastroenterol Hepatol] 2020; Vol. 10 (4), pp. 779-796. Date of Electronic Publication: 2020 Jun 16.