Synthetic immune signaling

Autor: Schamel, Wolfgang WA, Reth, Michael

Publikováno v: In Current Opinion in Biotechnology October 2012 23(5):780-784

Stoichiometry and intracellular fate of TRIM-containing TCR complexes

Autor: Dopfer Elaine P, Molnar Eszter, Fiala Gina J, Siegers Gabrielle M, Swamy Mahima, Fisch Paul, Schraven Burkhart, Schamel Wolfgang WA

Publikováno v: Cell Communication and Signaling, Vol 8, Iss 1, p 5 (2010)

Abstract Background Studying the stoichiometry and intracellular trafficking of the T cell antigen receptor (TCR) is pivotal in understanding its mechanisms of activation. The αβTCR includes the antigen-binding TCRαβ heterodimer as well as the si

Externí odkaz: https://doaj.org/article/c7540fb4c26a4fbbb2e41a0b1e0adb31

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Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor.

Autor: Yousefi OS; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Spemann Graduate School of Biology and Medicine, University of Freiburg, Freiburg, Germany., Günther M; Division of Theoretical Systems Biology, German Cancer Research Center, Heidelberg, Germany.; BioQuant Center, University of Heidelberg, Heidelberg, Germany., Hörner M; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Chalupsky J; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency, Medical Center Freiburg and Faculty of Medicine, University of Freiburg, Freiburg, Germany., Wess M; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Brandl SM; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Smith RW; Laboratory of Systems and Synthetic Biology, Wageningen University and Research, Wageningen, Netherlands., Fleck C; Laboratory of Systems and Synthetic Biology, Wageningen University and Research, Wageningen, Netherlands., Kunkel T; Faculty of Biology, University of Freiburg, Freiburg, Germany., Zurbriggen MD; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Institute of Synthetic Biology and Cluster of Excellence on Plant Sciences, University of Düsseldorf, Düsseldorf, Germany., Höfer T; Division of Theoretical Systems Biology, German Cancer Research Center, Heidelberg, Germany.; BioQuant Center, University of Heidelberg, Heidelberg, Germany., Weber W; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Schamel WW; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Laboratory of Systems and Synthetic Biology, Wageningen University and Research, Wageningen, Netherlands.

Publikováno v: ELife [Elife] 2019 Apr 05; Vol. 8. Date of Electronic Publication: 2019 Apr 05.