Strategies to design clinical studies to identify predictive biomarkers in cancer research

Autor: Perez-Gracia, JL, Sanmamed, MF, Bosch, A, Patino-Garcia, A, Schalper, KA, Segura, V, Bellmunt, J, Tabernero, J, Sweeney, CJ, Choueiri, TK, Martin, M, Fusco, JP, Rodriguez-Ruiz, ME, Calvo, A, Prior, C, Paz-Ares, L, Pio, R, Gonzalez-Billalabeitia, E, Hernandez, AG, Paez, D, Piulats, JM, Gurpide, A, Andueza, M, de Velasco, G, Pazo, R, Grande, E, Nicolas, P, Abad-Santos, F, Garcia-Donas, J, Castellano, D, Pajares, MJ, Suarez, C, Colomer, R, Montuenga, LM, Melero, I

Publikováno v: CANCER TREATMENT REVIEWS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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The discovery of reliable biomarkers to predict efficacy and toxicity of anticancer drugs remains one of the key challenges in cancer research. Despite its relevance, no efficient study designs to identify promising candidate biomarkers have been est

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::bba5564c7b4868c57c5f7e2df3995fcb
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6683

BCAM (basal cell adhesion molecule) protein expression in different tumor populations.

Autor: Burela S; Department of Pathology, Yale School of Medicine, New Haven, CT, 06519, USA., He M; Department of Pathology, Yale School of Medicine, New Haven, CT, 06519, USA., Trontzas IP; Department of Pathology, Yale School of Medicine, New Haven, CT, 06519, USA., Gavrielatou N; School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Schalper KA; Department of Pathology, Yale School of Medicine, New Haven, CT, 06519, USA., Langermann S; NextCure Inc, Beltsville, MD, USA., Flies DB; NextCure Inc, Beltsville, MD, USA., Rimm DL; Department of Pathology, Yale School of Medicine, New Haven, CT, 06519, USA. david.rimm@yale.edu., Aung TN; Department of Pathology, Yale School of Medicine, New Haven, CT, 06519, USA. thazin.aung@yale.edu.

Publikováno v: Discover oncology [Discov Oncol] 2024 Aug 29; Vol. 15 (1), pp. 381. Date of Electronic Publication: 2024 Aug 29.

High-throughput transcriptome profiling indicates ribosomal RNAs to be associated with resistance to immunotherapy in non-small cell lung cancer (NSCLC).

Autor: Moutafi MK; Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA., Bates KM; Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA., Aung TN; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA.; Yale School of Medicine, New Haven, Connecticut, USA., Milian RG; Bioinformatics Support Program, Cushing/Whitney Medical Library, Yale School of Medicine, New Haven, Connecticut, USA., Xirou V; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA.; Yale School of Medicine, New Haven, Connecticut, USA., Vathiotis IA; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA., Gavrielatou N; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA.; Yale School of Medicine, New Haven, Connecticut, USA., Angelakis A; Epidemiology and Data Science, Amsterdam UMC Locatie AMC, Amsterdam, The Netherlands.; Department of Methodology, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Schalper KA; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA., Salichos L; Biomedical Data Science Center Director, Center for Cancer Research, Department of Computational Biology at New York Institute of Technology, New York Institute of Technology, Old Westbury, New York, USA., Rimm DL; Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA david.rimm@yale.edu.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2024 Jun 10; Vol. 12 (6). Date of Electronic Publication: 2024 Jun 10.

Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity.

Autor: Zhang T; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Yu W; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Cheng X; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Yeung J; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA., Ahumada V; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Norris PC; Sciex Demo Lab, Framingham, MA, USA., Pearson MJ; Sciex Demo Lab, Framingham, MA, USA., Yang X; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., van Deursen W; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Halcovich C; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Nassar A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Vesely MD; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA., Zhang Y; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Zhang JP; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Ji L; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Flies DB; NextCure Inc., Beltsville, MD, USA., Liu L; NextCure Inc., Beltsville, MD, USA., Langermann S; NextCure Inc., Beltsville, MD, USA., LaRochelle WJ; Normunity Inc., Boston, MA, USA., Humphrey R; Normunity Inc., Boston, MA, USA., Zhao D; Yale Center for Genome Analysis, Yale University, New Haven, CT, USA., Zhang Q; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Zhang J; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Gu R; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Schalper KA; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Sanmamed MF; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Program of Immunology and Immunotherapy, Center for Applied Medical Research, University of Navarra, Pamplona, Spain., Chen L; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

Publikováno v: Science immunology [Sci Immunol] 2024 Apr 26; Vol. 9 (94), pp. eadh2334. Date of Electronic Publication: 2024 Apr 26.

Distinct genomic and immunologic tumor evolution in germline TP53 -driven breast cancers.

Autor: Boruah N; Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Hoyos D; Computational Oncology, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY., Moses R; Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Hausler R; Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Desai H; Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Le AN; Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Good M; Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Kelly G; Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Raghavakaimal A; Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Tayeb M; Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Narasimhamurthy M; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA., Doucette A; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Gabriel P; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Feldman MJ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA., Park J; Departments of Medicine and Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY., de Rodas ML; Department of Pathology, Yale School of Medicine, New Haven, CT., Schalper KA; Department of Pathology, Yale School of Medicine, New Haven, CT., Goldfarb SB; Departments of Medicine and Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical Center, New York, NY., Nayak A; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA., Levine AJ; Institute for Advanced Study, Princeton, NJ., Greenbaum BD; Computational Oncology, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Physiology, Biophysics & Systems Biology, Weill Cornell Medical Center, New York, NY., Maxwell KN; Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 05. Date of Electronic Publication: 2024 Apr 05.