Apolipoprotein L1 (APOL1) cation current in HEK-293 cells and in human podocytes

Autor: Vandorpe, David H., Heneghan, John F., Waitzman, Joshua S., McCarthy, Gizelle M., Blasio, Angelo, Magraner, Jose M., Donovan, Olivia G., Schaller, Lena B., Shah, Shrijal S., Subramanian, Balaji K., Riella, Cristian V., Friedman, David J., Pollak, Martin R., Alper, Seth L.

Publikováno v: Pflugers Arch

Two heterozygous missense variants (G1 and G2) of Apolipoprotein L1 (APOL1) found in individuals of recent African ancestry can attenuate the severity of infection by some forms of Trypanosoma brucei. However, these two variants within a broader Afri

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https://doi.org/10.1007/s00424-022-02767-8

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Apolipoprotein L1 (APOL1) cation current in HEK-293 cells and in human podocytes.

Autor: Vandorpe DH; Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center RN380F, 99 Brookline Ave, Boston, MA, 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., Heneghan JF; Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center RN380F, 99 Brookline Ave, Boston, MA, 02215, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, 02215, USA., Waitzman JS; Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center RN380F, 99 Brookline Ave, Boston, MA, 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., McCarthy GM; Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center RN380F, 99 Brookline Ave, Boston, MA, 02215, USA.; Vertex Pharmaceuticals, Boston, MA, 02210, USA., Blasio A; Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center RN380F, 99 Brookline Ave, Boston, MA, 02215, USA.; Vertex Pharmaceuticals, Boston, MA, 02210, USA., Magraner JM; Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center RN380F, 99 Brookline Ave, Boston, MA, 02215, USA.; San Diego, CA, USA., Donovan OG; Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center RN380F, 99 Brookline Ave, Boston, MA, 02215, USA., Schaller LB; Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center RN380F, 99 Brookline Ave, Boston, MA, 02215, USA.; Ludwig-Maximilians-Universitaet, 80336, Munich, Germany., Shah SS; Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center RN380F, 99 Brookline Ave, Boston, MA, 02215, USA.; Chroma Medicine, Cambridge, MA, 02142, USA., Subramanian B; Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center RN380F, 99 Brookline Ave, Boston, MA, 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., Riella CV; Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center RN380F, 99 Brookline Ave, Boston, MA, 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., Friedman DJ; Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center RN380F, 99 Brookline Ave, Boston, MA, 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, 02139, USA., Pollak MR; Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center RN380F, 99 Brookline Ave, Boston, MA, 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, 02139, USA., Alper SL; Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center RN380F, 99 Brookline Ave, Boston, MA, 02215, USA. salper@bidmc.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA. salper@bidmc.harvard.edu.; Broad Institute of Harvard and MIT, Cambridge, MA, 02139, USA. salper@bidmc.harvard.edu.

Publikováno v: Pflugers Archiv : European journal of physiology [Pflugers Arch] 2023 Mar; Vol. 475 (3), pp. 323-341. Date of Electronic Publication: 2022 Nov 30.