Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array

Autor: Mansell, Georgina, Gorrie-Stone, Tyler J., Bao, Yanchun, Kumari, Meena, Schalkwyk, Leonard S., Mill, Jonathan, Hannon, Eilis

Publikováno v: BMC Genomics, Vol 20, Iss 1, Pp 1-15 (2019)
BMC Genomics

Background There has been a steady increase in the number of studies aiming to identify DNA methylation differences associated with complex phenotypes. Many of the challenges of epigenetic epidemiology regarding study design and interpretation have b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a7ceb4e23b95d82132428c4bca6e482e
http://link.springer.com/article/10.1186/s12864-019-5761-7

Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia

Autor: Hannon, Eilis, Dempster, Emma L, Mansell, Georgina, Burrage, Joe, Bass, Nick, Bohlken, Marc M, Corvin, Aiden, Curtis, Charles J, Dempster, David, Di Forta, Marta, Dinan, Timothy G, Donohoe, Gary, Gaughran, Fiona, Gill, Michael, Gillespie, Amy, Gunasinghe, Cerisse, Hulshoff, Hilleke E, Hultman, Christina M, Johansson, Viktoria, Kahn, Rene S, Kaprio, Jaakko, Kenis, Gunter, Kowalec, Kaarina, MacCabe, James, McDonald, Colm, McQuillin, Andew, Morris, Derek W, Murphy, Kieran C, Mustard, Collette, Nenadic, Igor, O’Donovan, Michael C, Quattrone, Diego, Richards, Alexander L, Rutten, Bart PF, Clair, David St, Therman, Sebastian, Toulopoulou, Timothea, Van Os, Jim, Waddington, John L, Sullivan, Patrick, Vassos, Evangelos, Breen, Gerome, Collier, David Andrew, Murray, Robin, Schalkwyk, Leonard S, Mill, Jonathan

ObjectivePsychosis - a complex and heterogeneous neuropsychiatric condition characterized by hallucinations and delusions - is a common feature of schizophrenia. There is evidence for altered DNA methylation (DNAm) associated with schizophrenia in bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf75fdff9a1bd08deb383db1f319ba4

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The correlation between reading and mathematics ability at age twelve has a substantial genetic component.

Autor: Davis OS; 1] Department of Genetics, Evolution and Environment, UCL Genetics Institute, University College London, London WC1E 6BT, UK [2] King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK [3]., Band G; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK [2]., Pirinen M; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK [2]., Haworth CM; 1] King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK [2] Department of Psychology, University of Warwick, Coventry CV4 7AL, UK., Meaburn EL; Department of Psychological Sciences, Birkbeck, University of London, London WC1E 7HX, UK., Kovas Y; Department of Psychology, Goldsmiths, University of London, London SE14 6NW, UK., Harlaar N; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado 80309-0345, USA., Docherty SJ; King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK., Hanscombe KB; King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK., Trzaskowski M; King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK., Curtis CJ; King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK., Strange A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Freeman C; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Bellenguez C; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Su Z; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Pearson R; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Vukcevic D; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Langford C; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK., Deloukas P; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK., Hunt S; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK., Gray E; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK., Dronov S; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK., Potter SC; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK., Tashakkori-Ghanbaria A; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK., Edkins S; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK., Bumpstead SJ; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK., Blackwell JM; 1] Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Crawley, Western Australia, Australia [2] Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Cambridge CB2 0XY, UK., Bramon E; 1] UCL Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, UK [2] UCL Mental Health Sciences Unit, University College London, London W1W 7EJ, UK., Brown MA; University of Queensland Diamantia Institute, Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland QLD 4102, Australia., Casas JP; 1] Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK [2] Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK., Corvin A; Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin 2, Ireland., Duncanson A; Molecular and Physiological Sciences, The Wellcome Trust, London NW1 2BE, UK., Jankowski JA; 1] Centre for Digestive Diseases, Blizard Institute, Queen Mary University of London, London E1 2AT, UK [2] Wolfson College, Linton Road, Oxford OX2 6UD, UK [3] Peninsula School of Medicine and Dentistry, Associate Deans Office, John Bull Building, Plymouth PL6 8BU, UK., Markus HS; Clinical Neurosciences, Saint George's University of London, London SW17 0RE, UK., Mathew CG; Department of Medical and Molecular Genetics, King's College London, King's Health Partners Guy's Hospital, London SE1 9RT, UK., Palmer CN; Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Rautanen A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Sawcer SJ; Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK., Trembath RC; Department of Medical and Molecular Genetics, King's College London, King's Health Partners Guy's Hospital, London SE1 9RT, UK., Viswanathan AC; NIHR Biomedical Research Centre at Moorfields Eye Hospital NHSFT and UCL Institute of Ophthalmology, London EC1V 2PD, UK., Wood NW; Department of Molecular Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK., Barroso I; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK., Peltonen L; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK., Dale PS; Department of Speech and Hearing Sciences, University of New Mexico, Albuquerque, New Mexico 87131, USA., Petrill SA; Department of Family Science, Institute for Population Research, The Ohio State University, Columbus, Ohio 43210, USA., Schalkwyk LS; King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK., Craig IW; King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK., Lewis CM; King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK., Price TS; Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-5158, USA., Donnelly P; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK [2] Department of Statistics, University of Oxford, Oxford OX1 3TG, UK., Plomin R; 1] King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK [2]., Spencer CC; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK [2].

Publikováno v: Nature communications [Nat Commun] 2014 Jul 08; Vol. 5, pp. 4204. Date of Electronic Publication: 2014 Jul 08.