Total Synthesis and Biological Evaluation of Rakicidin A and Discovery of a Simplified Bioactive Analogue.

Autor: Tsakos M; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000, Aarhus C, Denmark., Clement LL; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000, Aarhus C, Denmark., Schaffert ES; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000, Aarhus C, Denmark., Olsen FN; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000, Aarhus C, Denmark., Rupiani S; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000, Aarhus C, Denmark., Djurhuus R; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000, Aarhus C, Denmark., Yu W; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000, Aarhus C, Denmark., Jacobsen KM; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000, Aarhus C, Denmark., Villadsen NL; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000, Aarhus C, Denmark., Poulsen TB; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000, Aarhus C, Denmark. thpou@chem.au.dk.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2016 Jan 18; Vol. 55 (3), pp. 1030-5. Date of Electronic Publication: 2015 Dec 04.

The natural product brartemicin is a high affinity ligand for the carbohydrate-recognition domain of the macrophage receptor mincle.

Autor: Jacobsen KM; Chemical Biology Laboratory , Department of Chemistry , Aarhus University , DK-8000 , Aarhus C , Denmark . Email: thpou@chem.au.dk., Keiding UB; Chemical Biology Laboratory , Department of Chemistry , Aarhus University , DK-8000 , Aarhus C , Denmark . Email: thpou@chem.au.dk ; Department of Forensic Medicine , Bioanalytical Unit , Aarhus University , Brendstrupgaardsvej 100 , 8200 Aarhus N , Denmark., Clement LL; Chemical Biology Laboratory , Department of Chemistry , Aarhus University , DK-8000 , Aarhus C , Denmark . Email: thpou@chem.au.dk., Schaffert ES; Chemical Biology Laboratory , Department of Chemistry , Aarhus University , DK-8000 , Aarhus C , Denmark . Email: thpou@chem.au.dk., Rambaruth ND; Department of Life Sciences , Imperial College , London SW7 2AZ , UK . Email: k.drickamer@imperial.ac.uk., Johannsen M; Department of Forensic Medicine , Bioanalytical Unit , Aarhus University , Brendstrupgaardsvej 100 , 8200 Aarhus N , Denmark., Drickamer K; Department of Life Sciences , Imperial College , London SW7 2AZ , UK . Email: k.drickamer@imperial.ac.uk., Poulsen TB; Chemical Biology Laboratory , Department of Chemistry , Aarhus University , DK-8000 , Aarhus C , Denmark . Email: thpou@chem.au.dk.

Publikováno v: MedChemComm [Medchemcomm] 2015 Apr 10; Vol. 6 (4), pp. 647-652. Date of Electronic Publication: 2015 Jan 07.

Aminomethyltetrazoles as potential inhibitors of the γ-aminobutyric acid transporters mGAT1-mGAT4: synthesis and biological evaluation.

Autor: Schaffert ES; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-University Munich, Butenandtstr. 5-13, D-81377 Munich, Germany., Höfner G, Wanner KT

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2011 Nov 01; Vol. 19 (21), pp. 6492-504. Date of Electronic Publication: 2011 Aug 26.