sp2-Iminosugar glycolipids as inhibitors of lipopolysaccharide-mediated human dendritic cell activation in vitro and of acute inflammation in mice in vivo

Autor: Schaeffer, Evelyne, Sánchez-Fernández, Elena M., Gonçalves-Pereira, Rita, Flacher, Vincent, Lamon, Delphine, Duval, Monique, Fauny, Jean-Daniel, García Fernández, José M., Mueller, Christopher G., Ortiz Mellet, Carmen

Publikováno v: In European Journal of Medicinal Chemistry 1 May 2019 169:111-120

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

Autor: Crouchet, Emilie, Bandiera, Simonetta, Fujiwara, Naoto, Li, Shen, El Saghire, Hussein, Fernández-Vaquero, Mirian, Riedl, Tobias, Sun, Xiaochen, Hirschfield, Hadassa, Jühling, Frank, Zhu, Shijia, Roehlen, Natascha, Ponsolles, Clara, Heydmann, Laura, Saviano, Antonio, Qian, Tongqi, Venkatesh, Anu, Lupberger, Joachim, Verrier, Eloi R., Sojoodi, Mozhdeh, Oudot, Marine A., Duong, François H. T., Masia, Ricard, Wei, Lan, Thumann, Christine, Durand, Sarah C., González-Motos, Victor, Heide, Danijela, Hetzer, Jenny, Nakagawa, Shigeki, Ono, Atsushi, Song, Won-Min, Higashi, Takaaki, Sanchez, Roberto, Kim, Rosa S., Bian, C. Billie, Kiani, Karun, Croonenborghs, Tom, Subramanian, Aravind, Chung, Raymond T., Straub, Beate K., Schuppan, Detlef, Ankavay, Maliki, Cocquerel, Laurence, Schaeffer, Evelyne, Goossens, Nicolas, Koh, Anna P., Mahajan, Milind, Nair, Venugopalan D., Gunasekaran, Ganesh, Schwartz, Myron E., Bardeesy, Nabeel, Shalek, Alex K., Rozenblatt-Rosen, Orit, Regev, Aviv, Felli, Emanuele, Pessaux, Patrick, Tanabe, Kenneth K., Heikenwälder, Mathias, Schuster, Catherine, Pochet, Nathalie, Zeisel, Mirjam B., Fuchs, Bryan C., Hoshida, Yujin, Baumert, Thomas F.

Publikováno v: Nature Communications
Nature Communications, 2021, 12 (1), pp.5525. ⟨10.1038/s41467-021-25468-9⟩
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.5525. ⟨10.1038/s41467-021-25468-9⟩

Chronic liver disease and hepatocellular carcinoma (HCC) are life-threatening diseases with limited treatment options. The lack of clinically relevant/tractable experimental models hampers therapeutic discovery. Here, we develop a simple and robust h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f0c52e28e4771781df271af268b8f8f4
https://hal.science/hal-03395220/document

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