Platelet-instructed SPP1 ⁺ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner.

Autor: Hoeft K; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Schaefer GJL; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Kim H; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Schumacher D; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany; Department of Anesthesiology, RWTH Aachen University, Aachen, Germany., Bleckwehl T; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Long Q; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Klinkhammer BM; Department of Pathology, RWTH Aachen University, Aachen, Germany., Peisker F; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Koch L; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Nagai J; Institute for Computational Genomics, RWTH Aachen University Hospital, Aachen, Germany; Joint Research Center for Computational Biomedicine, RWTH Aachen University Hospital, Aachen, Germany., Halder M; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Ziegler S; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Liehn E; Institute for Molecular Medicine, University of South Denmark, Odense, Denmark., Kuppe C; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Kranz J; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany; Department of Urology, RWTH Aachen University, Aachen, Germany; Department of Urology and Kidney Transplantation, Martin-Luther-University, Halle (Saale), Germany., Menzel S; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Costa I; Institute for Computational Genomics, RWTH Aachen University Hospital, Aachen, Germany; Joint Research Center for Computational Biomedicine, RWTH Aachen University Hospital, Aachen, Germany., Wahida A; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany; Division of Gynecological Oncology, National Center for Tumor Diseases (NCT), Heidelberg, Germany., Boor P; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany; Department of Pathology, RWTH Aachen University, Aachen, Germany., Schneider RK; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands; Department of Cell Biology, Institute for Biomedical Technologies, RWTH Aachen University, Aachen, Germany., Hayat S; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Kramann R; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany; Department of Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, the Netherlands. Electronic address: rkramann@gmx.net.

Publikováno v: Cell reports [Cell Rep] 2023 Feb 28; Vol. 42 (2), pp. 112131. Date of Electronic Publication: 2023 Feb 18.