Menin inhibitors for the treatment of acute myeloid leukemia: challenges and opportunities ahead.

Autor: Nadiminti, Kalyan V. G.¹ (AUTHOR) knadimin@medicine.wisc.edu, Sahasrabudhe, Kieran D.¹ (AUTHOR), Liu, Hongtao¹ (AUTHOR)

Publikováno v: Journal of Hematology & Oncology. 11/18/2024, Vol. 17 Issue 1, p1-16. 16p.

Distinct Responses to Menin Inhibition and Synergy with DOT1L Inhibition in KMT2A -Rearranged Acute Lymphoblastic and Myeloid Leukemia.

Autor: Adriaanse, Fabienne R. S.^1,2 (AUTHOR), Schneider, Pauline¹ (AUTHOR), Arentsen-Peters, Susan T. C. J. M.¹ (AUTHOR), Fonseca, Ana M. Neves da¹ (AUTHOR), Stutterheim, Janine¹ (AUTHOR), Pieters, Rob¹ (AUTHOR), Zwaan, C. Michel^1,2 (AUTHOR), Stam, Ronald W.¹ (AUTHOR) r.w.stam@prinsesmaximacentrum.nl

Publikováno v: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p6020. 14p.

Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma.

Autor: Goyal L; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Saha SK; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Liu LY; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Siravegna G; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Torino, Italy.; Department of Oncology, University of Torino, Torino, Italy.; Fondazione Italiana per la Ricerca sul Cancro (FIRC) Institute of Molecular Oncology (IFOM), Milano, Italy., Leshchiner I; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts., Ahronian LG; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Lennerz JK; Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts., Vu P; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Deshpande V; Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts., Kambadakone A; Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts., Mussolin B; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Torino, Italy., Reyes S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Henderson L; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Sun JE; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Van Seventer EE; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Gurski JM Jr; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Baltschukat S; Novartis Institutes for BioMedical Research, Oncology Translational Research, Basel, Switzerland., Schacher-Engstler B; Novartis Institutes for BioMedical Research, Oncology Translational Research, Basel, Switzerland., Barys L; Novartis Institutes for BioMedical Research, Oncology Translational Research, Basel, Switzerland., Stamm C; Novartis Institutes for BioMedical Research, Oncology Translational Research, Basel, Switzerland., Furet P; Novartis Institutes for BioMedical Research, Global Discovery Chemistry, Basel, Switzerland., Ryan DP; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Stone JR; Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts., Iafrate AJ; Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts., Getz G; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts., Porta DG; Novartis Institutes for BioMedical Research, Oncology Translational Research, Basel, Switzerland., Tiedt R; Novartis Institutes for BioMedical Research, Oncology Translational Research, Basel, Switzerland., Bardelli A; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Torino, Italy.; Department of Oncology, University of Torino, Torino, Italy., Juric D; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Corcoran RB; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts. azhu@partners.org nbardeesy@partners.org rbcorcoran@partners.org., Bardeesy N; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts. azhu@partners.org nbardeesy@partners.org rbcorcoran@partners.org., Zhu AX; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts. azhu@partners.org nbardeesy@partners.org rbcorcoran@partners.org.

Publikováno v: Cancer discovery [Cancer Discov] 2017 Mar; Vol. 7 (3), pp. 252-263. Date of Electronic Publication: 2016 Dec 29.

The PedAL/EuPAL Project: A Global Initiative to Address the Unmet Medical Needs of Pediatric Patients with Relapsed or Refractory Acute Myeloid Leukemia.

Autor: Ceolin, Valeria^1,2 (AUTHOR) v.c.ceolin@prinsesmaximacentrum.nl, Ishimaru, Sae¹ (AUTHOR) s.i.ishimaru@prinsesmaximacentrum.nl, Karol, Seth E.³ (AUTHOR) seth.karol@stjude.org, Bautista, Francisco^1,4 (AUTHOR) f.j.bautistasirvent@prinsesmaximacentrum.nl, Goemans, Bianca Frederika¹ (AUTHOR) b.f.goemans@prinsesmaximacentrum.nl, Gueguen, Gwenaëlle⁵ (AUTHOR) gwenaelle.gueguen@aphp.fr, Willemse, Marieke¹ (AUTHOR) m.e.willemse@prinsesmaximacentrum.nl, Di Laurenzio, Laura⁶ (AUTHOR) laura.dilaurenzio@lls.org, Lukin, Jennifer⁶ (AUTHOR) jennifer.lukin@lls.org, van Tinteren, Harm¹ (AUTHOR) h.vantinteren@prinsesmaximacentrum.nl, Locatelli, Franco⁷ (AUTHOR) franco.locatelli@opbg.net, Petit, Arnaud⁸ (AUTHOR) arnaud.petit@aphp.fr, Tomizawa, Daisuke⁹ (AUTHOR) tomizawa-d@ncchd.go.jp, Norton, Alice¹⁰ (AUTHOR) alice.norton1@nhs.net, Kaspers, Gertjan^1,11 (AUTHOR) g.j.l.kaspers@prinsesmaximacentrum.nl, Reinhardt, Dirk¹² (AUTHOR) dirk.reinhardt@uk-essen.de, Tasian, Sarah K.¹³ (AUTHOR) tasians@chop.edu, Nichols, Gwen⁶ (AUTHOR) gwen.nichols@lls.org, Kolb, Edward Anders⁶ (AUTHOR), Zwaan, Christian Michel^1,4,14 (AUTHOR) c.m.zwaan@prinsesmaximacentrum.nl

Publikováno v: Cancers. Jan2024, Vol. 16 Issue 1, p78. 17p.

Menin in Cancer.

Autor: Majer, Ariana D., Hua, Xianxin, Katona, Bryson W.

Publikováno v: Genes; Sep2024, Vol. 15 Issue 9, p1231, 50p