Výsledky vyhledávání - "Schaafsma Dedmer"

Akademický článek

Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts

Autor: Ghavami Saeid, Mutawe Mark M, McNeill Karol D, Schaafsma Dedmer, Unruh Helmut, Jacques Eric, Laviolette Michel, Chakir Jamila, Halayko Andrew J

Publikováno v: Respiratory Research, Vol 12, Iss 1, p 113 (2011)

Abstract Background Bronchial fibroblasts contribute to airway remodelling, including airway wall fibrosis. Transforming growth factor (TGF)-β1 plays a major role in this process. We previously revealed the importance of the mevalonate cascade in th

Externí odkaz: https://doaj.org/article/d73d0b822f494723b8ecfe9c40e27ad8

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Akademický článek

Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperresponsiveness after the early and late asthmatic reaction

Autor: Zaagsma Johan, Zuidhof Annet B, Bos I Sophie T, Schaafsma Dedmer, Meurs Herman

Publikováno v: Respiratory Research, Vol 7, Iss 1, p 121 (2006)

Abstract Background In guinea pigs, we have previously demonstrated that the contribution of Rho-kinase to airway responsiveness in vivo and ex vivo is enhanced after active sensitization with ovalbumin (OA). Using conscious, unrestrained OA-sensitiz

Externí odkaz: https://doaj.org/article/8b4b11c0b2064471b052d03b884bd46b

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Akademický článek

Role of contractile prostaglandins and Rho-kinase in growth factor-induced airway smooth muscle contraction

Autor: Zaagsma Johan, Meurs Herman, Bos I Sophie T, Gosens Reinoud, Schaafsma Dedmer, Nelemans S Adriaan

Publikováno v: Respiratory Research, Vol 6, Iss 1, p 85 (2005)

Abstract Background In addition to their proliferative and differentiating effects, several growth factors are capable of inducing a sustained airway smooth muscle (ASM) contraction. These contractile effects were previously found to be dependent on

Externí odkaz: https://doaj.org/article/456684644743413b8a7e7f33a412f810

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