Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

Autor: Papa, Feroz, Oakes, Scott, Wang, L, Perera, BGK, Hari, SB, Bhhatarai, B, Backes, BJ, Seeliger, MA, Schürer, SC, Oakes, SA, Papa, FR, Maly, DJ

Publikováno v: Papa, Feroz; Oakes, Scott; Wang, L; Perera, BGK; Hari, SB; Bhhatarai, B; et al.(2012). Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/35m2c219

Under endoplasmic reticulum stress, unfolded protein accumulation leads to activation of the endoplasmic reticulum transmembrane kinase/endoRNase (RNase) IRE1α. IRE1α oligomerizes, autophosphorylates and initiates splicing of XBP1 mRNA, thus trigge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::c8aa756f8712ba1353b09419aee104ab
http://www.escholarship.org/uc/item/35m2c219

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Multiscale mapping of transcriptomic signatures for cardiotoxic drugs.

Autor: Hansen J; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. jens.hansen@mssm.edu.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. jens.hansen@mssm.edu., Xiong Y; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Siddiq MM; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Dhanan P; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Hu B; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Shewale B; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Yadaw AS; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Jayaraman G; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Tolentino RE; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Chen Y; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Martinez P; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Beaumont KG; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Sebra R; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Vidovic D; Institute for Data Science and Computing, University of Miami, Coral Gables, FL, 33146, USA., Schürer SC; Institute for Data Science and Computing, University of Miami, Coral Gables, FL, 33146, USA., Goldfarb J; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Gallo JM; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; School of Pharmacy and Pharmaceutical Sciences, University of Buffalo SUNY System, Buffalo, NY, 14260, USA., Birtwistle MR; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Chemical and Biomolecular Engineering, Clemson University, Clemson, SC, 29634, USA., Sobie EA; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Azeloglu EU; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New, York, NY, 10029, USA., Berger SI; Center for Genetic Medicine Research, Children's National Research Institute, Washington, DC, 20012, USA., Chan A; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Cardiology Division, Department of Medicine, Memorial Sloan Kettering Cancer Center New York, New York, NY, 10065, USA., Schaniel C; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Medicine, Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Dubois NC; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Dubois@mssm.edu.; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Dubois@mssm.edu., Iyengar R; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. ravi.iyengar@mssm.edu.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. ravi.iyengar@mssm.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 11; Vol. 15 (1), pp. 7968. Date of Electronic Publication: 2024 Sep 11.

Potent, Selective, and Orally Bioavailable Quinazoline-Based STK17A/B Dual Inhibitors.

Autor: Chaudhry S; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida33136, United States., Castro JR; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida33136, United States., Totiger TM; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida33136, United States., Afaghani J; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida33136, United States., Khurshid R; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida 33136, United States., Nicholls M; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida33136, United States., Zhang Z; Department of Chemistry, University of Miami, Miami, Florida 33146, United State., Schürer SC; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida33136, United States.; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida 33136, United States., Shah A; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida33136, United States., Taylor J; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida33136, United States., Feng Y; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida33136, United States.; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida 33136, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 May 20; Vol. 15 (6), pp. 945-949. Date of Electronic Publication: 2024 May 20 (Print Publication: 2024).

Wastewater based surveillance can be used to reduce clinical testing intensity on a university campus.

Autor: Amirali A; Department of Chemical, Environmental, and Materials Engineering, University of Miami, Coral Gables, FL 33146, USA., Babler KM; Department of Chemical, Environmental, and Materials Engineering, University of Miami, Coral Gables, FL 33146, USA., Sharkey ME; Department of Medicine, University of Miami Miller School of Medicine, Miami, 33136, FL, USA., Beaver CC; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Boone MM; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Comerford S; Department of Medicine, University of Miami Miller School of Medicine, Miami, 33136, FL, USA., Cooper D; DataGrade Solutions, LLC, Miami, FL 33136, USA., Currall BB; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Goodman KW; Frost Institute for Data Science & Computing, University of Miami, Coral Gables, FL 33146, USA; Institute for Bioethics and Health Policy, University of Miami Miller School of Medicine, Miami, 33136, FL, USA., Grills GS; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Kobetz E; Department of Medicine, University of Miami Miller School of Medicine, Miami, 33136, FL, USA., Kumar N; Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Laine J; Environmental Health and Safety, University of Miami, Miami, FL 33136, USA., Lamar WE; Division of Occupational Health, Safety & Compliance, University of Miami Health System, Miami, FL 33136, USA., Mason CE; Department of Physiology and Biophysics, Weill Cornell Medical College, New York City, NY 10021, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY 10021, USA., Reding BD; Environmental Health and Safety, University of Miami, Miami, FL 33136, USA., Roca MA; Department of Chemical, Environmental, and Materials Engineering, University of Miami, Coral Gables, FL 33146, USA., Ryon K; Department of Physiology and Biophysics, Weill Cornell Medical College, New York City, NY 10021, USA., Schürer SC; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Molecular & Cellular Pharmacology, University of Miami Miller School of Medicines, Miami, FL 33136, USA; Institute for Data Science & Computing, University of Miami, Coral Gables, FL 33146, USA., Shukla BS; Department of Medicine, University of Miami Miller School of Medicine, Miami, 33136, FL, USA., Solle NS; Department of Medicine, University of Miami Miller School of Medicine, Miami, 33136, FL, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Stevenson M; Department of Chemical, Environmental, and Materials Engineering, University of Miami, Coral Gables, FL 33146, USA., Tallon JJ Jr; Facilities and Operations, University of Miami, Coral Gables, FL 33146, USA., Vidović D; Department of Chemical, Environmental, and Materials Engineering, University of Miami, Coral Gables, FL 33146, USA., Williams SL; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Yin X; Department of Chemical, Environmental, and Materials Engineering, University of Miami, Coral Gables, FL 33146, USA., Solo-Gabriele HM; Department of Chemical, Environmental, and Materials Engineering, University of Miami, Coral Gables, FL 33146, USA. Electronic address: hmsolo@miami.edu.

Publikováno v: The Science of the total environment [Sci Total Environ] 2024 Mar 25; Vol. 918, pp. 170452. Date of Electronic Publication: 2024 Jan 29.